Chronic imipramine treatment-induced changes in acetylcholinesterase (EC 3.1.1.7) activity in discrete rat brain regions [PDF]
Brazilian Journal of Medical and Biological Research, 1997 Cholinergic as well as monoaminergic neurotransmission seems to be involved in the etiology of affective disorders. Chronic treatment with imipramine, a classical antidepressant drug, induces adaptive changes in monoaminergic neurotransmission.
R. Camarini, M.A.C. Benedito
doaj +3 more sources
Imipramine Induces Brain-Derived Neurotrophic Factor mRNA Expression in Cultured Astrocytes
Journal of Pharmacological Sciences, 2012 Depression is one of the most prevalent and livelihood-threatening forms of mental illnesses and the neural circuitry underlying depression remains incompletely understood.
Katsura Takano +4 more
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The rise and fall of "<i>Nippon no utsu-byo</i> ニッポンのうつ" (the concept of Nippon depressive disease) in Japan. [PDF]
PCN RepAbstract From around 1960 to 2000, Japanese psychiatrists used their own concept of depression (Utsu‐byo うつ病). To distinguish this from major depressive disorder (MDD), the present concept of depression according to the revised version of the Diagnostic and Statistical Manual of Mental Disorders, 5th edition, the present author refers to this concept ...
Ohmae S.
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Journal of Cellular and Molecular Medicine, 2021 Patients with malignant glioma often suffered from depression, which leads to an increased risk of detrimental outcomes. Imipramine, an FDA‐approved tricyclic antidepressant, has been commonly used to relieve depressive symptoms in the clinic.
Yan Wang +12 more
semanticscholar +1 more source
New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells
Experimental and Molecular Medicine, 2020 Serrated adenocarcinoma (SAC) is more invasive, has worse outcomes than conventional colorectal carcinoma (CRC), and is characterized by frequent resistance to anti-epidermal growth factor receptor (EGFR) and overexpression of fascin1, a key protein in ...
Begoña Alburquerque-González +12 more
semanticscholar +1 more source
Journal of Cellular and Molecular Medicine, 2020 Glioblastomas are the most aggressive type of brain tumour, with poor prognosis even after standard treatment such as surgical resection, temozolomide and radiation therapy. The overexpression of the nuclear factor kappa‐light‐chain‐enhancer of activated
Fei-Ting Hsu +2 more
semanticscholar +1 more source
Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. [PDF]
, 2004 We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naive rats during forced-swim testing.
Araki, Hiroaki +5 more
core +1 more source
Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells. [PDF]
, 2017 Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid leukemia (AML).
Arbiser, Jack L +6 more
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Effects of Imipramine and Lithium on the Suppression of Cell Proliferation in the Dentate Gyrus of the Hippocampus in Adrenocorticotropic Hormone-treated Rats [PDF]
, 2010 We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells.
Asanuma, Masato +9 more
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Veterinary Sciences, 2021 Imipramine is a tricyclic antidepressant that has been approved for treating depression and anxiety in patients and animals and that has relatively mild side effects.
Geng-Ruei Chang +8 more
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