Results 21 to 30 of about 51,042 (305)

Imipramine protects retinal ganglion cells from oxidative stress through the tyrosine kinase receptor B signaling pathway

Neural Regeneration Research, 2016
Retinal ganglion cell (RGC) degeneration is irreversible in glaucoma and tyrosine kinase receptor B (TrkB)-associated signaling pathways have been implicated in the process.
Ming-lei Han, Guo-hua Liu, Jin Guo, Shu-juan Yu, Jing Huang   +4 more
doaj   +1 more source

The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. [PDF]

, 2011
The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death.
Anish Bali, Asher, Viren, Averil Warren, Heidi Sowter, Raheela Khan, Robert Shaw, Viren Asher   +6 more
core   +5 more sources

Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence

British medical journal, 2015
Objectives To reanalyse SmithKline Beecham’s Study 329 (published by Keller and colleagues in 2001), the primary objective of which was to compare the efficacy and safety of paroxetine and imipramine with placebo in the treatment of adolescents with ...
J. Le Noury, John M. Nardo, D. Healy, J. Jureidini, M. Raven, C. Tufanaru, Elia Abi-Jaoude   +6 more
semanticscholar   +1 more source

Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice [PDF]

, 2015
Poor micturition control may cause profound distress, because proper voiding is mandatory for an active social life. Micturition results from the subtle interplay of central and peripheral components.
Antonio, Caretta, Claus, Mirko, Mar\ueda Jimena, Ricatti, Maurizio, Ballabio, Mucignat, Carla, Redaelli, Marco, Simonetto, Marialaura   +6 more
core   +4 more sources

Serum fetuin-A in major depressive disorder: Lower levels in patients, but no correlation with symptom severity. [PDF]

PCN Rep
Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 3, September 2025.
Ikenouchi A, Fujii R, Yoshimura R.
europepmc   +2 more sources

Imipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking

Scientific Reports, 2017
Chikungunya virus (CHIKV) is an emerging arbovirus of the Togaviridae family that poses a present worldwide threat to human in the absence of any licensed vaccine or antiviral treatment to control viral infection. Here, we show that compounds interfering
Sineewanlaya Wichit, R. Hamel, Eric Bernard, L. Talignani, Fodé Diop, P. Ferraris, F. Liégeois, P. Ekchariyawat, Natthanej Luplertlop, Pornapat Surasombatpattana, Frédéric Thomas, A. Merits, V. Choumet, P. Roques, H. Yssel, L. Briant, D. Missé   +16 more
semanticscholar   +1 more source

Beta-adrenergic receptor blockers effects on the antinociceptive action of imipramine against thermal induced pain in albino mice

Libyan International Medical University Journal, 2016
Introduction: Tricyclic antidepressant have been shown to be effective in treatment of pain of varying etiology, monoaminergic system seems to be implicated in this phenomena.
H A Zawia, F A Blaou, A S Elhwuegi
doaj   +1 more source

Imipramine Inhibits Osteosarcoma Invasion via Src Inactivation and Caspase‐Dependent Apoptosis [PDF]

J Cell Mol Med
ABSTRACT Osteosarcoma (OS) is an aggressive malignancy characterised by high metastatic potential and poor prognosis. Imipramine, a tricyclic antidepressant, has shown potential anticancer effects. This study evaluates the cytotoxic, pro‐apoptotic and anti‐invasion effects of imipramine on OS cells in vitro and in vivo, as well as its underlying ...
Liu Y, Fang C, Hsu L, Hsu F, Hu M.
europepmc   +2 more sources

A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. [PDF]

, 2016
In humans, the connection between sleep and mood has long been recognized, although direct molecular evidence is lacking. We identified two rare variants in the circadian clock gene PERIOD3 (PER3-P415A/H417R) in humans with familial advanced sleep phase ...
Fu, Ying-Hui, Hirano, Arisa, Hsu, Pei-Ken, Jones, Christopher R, Kaasik, Krista, Lin, Shu-Ting, McMahon, Thomas, Nishino, Seiji, Okuro, Masashi, Ptáček, Louis J, Saigoh, Kazumasa, Saigoh, Noriko, Sakai, Noriaki, Xu, Ying, Yamazaki, Maya, Zhang, Luoying   +15 more
core   +1 more source

Chronic Treatment With Imipramine Inhibits Cell Growth and Enhances Serotonin 2C Receptor mRNA Expression in NG 108-15 Cells

Journal of Pharmacological Sciences, 2003
We previously reported that NG108-15 cells contain intrinsic serotonin 2C receptor (5-HT2CR). The effects of imipramine, a 5-HT2CR antagonist, on cell growth, cell viability, and the 5-HT2CR mRNA level were investigated in this study.
Monrudee Sukma, Michihisa Tohda, Hiroshi Watanabe   +2 more
doaj   +1 more source