Results 31 to 40 of about 19,050 (169)
Angewandte Chemie, Volume 137, Issue 25, June 17, 2025.Wir präsentieren eine metallfreie Methode für die Deuteriummarkierung von Aromaten in deuteriertem HFIP. Dieser Ansatz nutzt die erhöhte Basizität von Aromaten im angeregten Zustand, um den selektiven Wasserstoffisotopenaustausch an schwer zugänglichen Positionen zu ermöglichen.
Eva Rivera‐Chao +5 more
wiley +1 more source
Angewandte Chemie International Edition, Volume 64, Issue 25, June 17, 2025.We present a metal‐free method for aromatic deuterium labeling via photoexcitation in deuterated HFIP. This approach leverages the enhanced basicity of excited‐state aromatics to achieve selective hydrogen isotope exchange at challenging positions. Demonstrated on complex drug molecules, this efficient strategy provides a valuable tool for isotope ...
Eva Rivera‐Chao +5 more
wiley +1 more source
Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites
ChemMedChem, Volume 20, Issue 11, June 2, 2025.Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert +6 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1811-1819, June 2025.Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund +5 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 6, June 2025.Our research is the first to explore the neuroprotective effects of total saponin active compounds isolated from Panax quinquefolius after steaming different times, and to screen out those total saponins with better neuroprotective activity, as well as to conduct a preliminary study on their potential to improve learning and memory impairments. Results
Yuting Yang +7 more
wiley +1 more source
Trends in tricyclic antidepressant prescribing and poisoning in England and Wales 2016–2020
British Journal of Clinical Pharmacology, Volume 91, Issue 6, Page 1727-1738, June 2025.Abstract Aims Tricyclic antidepressants (TCAs) are commonly prescribed despite no longer being a NICE‐recommended first‐line treatment for depression and their recognized toxicity in overdose. This study examined prescribing, mortality, hospital admissions and clinical TCA data to quantify the use and impact of TCAs in England and Wales.
Laurence Gray +10 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1988 The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a subcortical motor area), was studied in freely moving rats by ...
G. Dichiara, A. Imperato
semanticscholar +1 more source
A randomized controlled trial of imipramine in patients with irritable bowel syndrome.
World Journal of Gastroenterology, 2009 AIM To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed.
Heitham Abdul‐Baki +7 more
semanticscholar +1 more source
Disturbance of Motor Function During Treatment with Imipramine [PDF]
, 1959 Avianna Foster, N. P. Lancaster
openalex +1 more source