Results 41 to 50 of about 38,854 (250)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Risk of gastrointestinal bleeding by specific SSRIs and SNRIs: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to estimate the risk of gastrointestinal bleeding (GIB) by selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs) individual agents. Methods A systematic review was conducted for each unique antidepressant (i.e.
Ainhoa Gomez‐Lumbreras, Abdelrahman G. Tawfik, Guilherme Del Fiol, Kensaku Kawamoto, Thomas Reese, Katy Trinkley, Aubrey Jones, James Mitchell, Daniel C. Malone   +8 more
wiley   +1 more source

α2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment [PDF]

, 2010
Slow-onset adaptive changes that arise from sustained antidepressant treatment, such as enhanced adult hippocampal neurogenesis and increased trophic factor expression, play a key role in the behavioral effects of antidepressants.
Bartlett, Perry, Fernandes, Kimberly, Hein, Lutz, Jha, Shanker, Jhaveri, Dhanisha, Ladiwala, Uma, Marathe, Swananda V., Muthig, Verena, Rommelfanger, Karen, Vadodaria, Krishna C., Vaidya, Vidita A., Weinshenker, David, Yanpallewar, Sudhirkumar U.   +12 more
core   +1 more source

Reduced prevalence of periodontitis in antidepressant users: Findings from a large‐scale US sample

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis and major depression disorder have been shown to have a bidirectional association. However, the impact of antidepressants, the primary pharmacological treatment for depression, on periodontal health remains unclear.
María Martínez, David Fraguas, Elena Figuero, Francesco D´Aiuto   +3 more
wiley   +1 more source

Imipramine Administration in Brucella abortus 2308-Infected Mice Restores Hippocampal Serotonin Levels, Muscle Strength, and Mood, and Decreases Spleen CFU Count

Pharmaceuticals, 2023
Brucellosis infection causes non-specific symptoms such as fever, chills, sweating, headaches, myalgia, arthralgia, anorexia, fatigue, and mood disorders. In mouse models, it has been associated with increased levels of IL-6, TNF-α, and IFN-γ, a decrease
José Luis Maldonado-García, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, Samantha Alvarez-Herrera, Lenin Pavón, Luvia Sánchez-Torres, Gabriel Gutiérrez-Ospina, Manuel Iván Girón-Pérez, Gabriela Damian-Morales, Jesús Octavio Maldonado-Tapia, Rubén López-Santiago, Martha C. Moreno-Lafont   +11 more
doaj   +1 more source

Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression [PDF]

, 2017
Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of and recovery from depression ...
A Mateus-Pinheiro, A Mateus-Pinheiro, A Mateus-Pinheiro, A Sahay, A Surget, A Surget, AD Simons, B Czeh, BS McEwen, C Schmidt-Hieber, C Yang, EY Fenton, F Hardeveld, G Dagyte, GS Kirshenbaum, J Fuss, J Fuss, JL Onksen, JM Bessa, JM Bessa, JM Bessa, JY Kim, K McAlonan, K Sim, KG Akers, L Clark, L Santarelli, L Suo, MA Kheirbek, MN Jayatissa, N Kee, N Toni, P Patricio, P Willner, R Bisaz, RJ Baldessarini, RJ Boland, S Ge, SD Hollon, SM Southwick, SW Chan, TD Schmittgen, TI Mueller, YF Li, YH Hsiao, YI Sheline   +45 more
core   +1 more source

Progress on the Application of Polymers of Intrinsic Microporosity for the Adsorption of Organic Contaminants

ChemistryOpen, EarlyView.
The pictorial illustration of the applications of polymers of intrinsic microporosity extraordinary porous organic polymers with high surface areas, pore radii, pore volumes, high permeability, high diffusivity, high selectivity, and high thermal stability, as suitable filters or purifiers for water contaminated with pharmaceutical and organic dyes ...
Martins O. Omorogie
wiley   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

The Paroxetine 352 Bipolar Study Revisited: Deconstruction of Corporate and Academic Misconduct [PDF]

, 2019
Medical ghostwriting is the practice in which pharmaceutical companies engage an outside writer to draft a manuscript submitted for publication in the names of “honorary authors,” typically academic key opinion leaders.
Amsterdam, Jay D., McHenry, Leemon
core  

Flexor Reflex Decreases during Sympathetic Stimulation in Chronic Human Spinal Cord Injury [PDF]

, 2009
A better understanding of autonomic influence on motor reflex pathways in spinal cord injury is important to the clinical management of autonomic dysreflexia and spasticity in spinal cord injured patients.
Garrison, Mark Kevin, Schmit, Brian D.
core   +2 more sources