Results 51 to 60 of about 38,471 (252)

Progress on the Application of Polymers of Intrinsic Microporosity for the Adsorption of Organic Contaminants

ChemistryOpen, EarlyView.
The pictorial illustration of the applications of polymers of intrinsic microporosity extraordinary porous organic polymers with high surface areas, pore radii, pore volumes, high permeability, high diffusivity, high selectivity, and high thermal stability, as suitable filters or purifiers for water contaminated with pharmaceutical and organic dyes ...
Martins O. Omorogie
wiley   +1 more source

The Paroxetine 352 Bipolar Study Revisited: Deconstruction of Corporate and Academic Misconduct [PDF]

, 2019
Medical ghostwriting is the practice in which pharmaceutical companies engage an outside writer to draft a manuscript submitted for publication in the names of “honorary authors,” typically academic key opinion leaders.
Amsterdam, Jay D., McHenry, Leemon
core  

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse

Acta Neuropathologica Communications, 2023
In Alzheimer’s disease (AD), reactive astrocytes produce extracellular vesicles (EVs) that affect mitochondria in neurons. Here, we show that Aβ-induced generation of the sphingolipid ceramide by acid sphingomyelinase (A-SMase) triggered proinflammatory ...
Simone M. Crivelli, Zainuddin Quadri, Hemendra J. Vekaria, Zhihui Zhu, Priyanka Tripathi, Ahmed Elsherbini, Liping Zhang, Patrick G. Sullivan, Erhard Bieberich   +8 more
doaj   +1 more source

Alprazolam for depression [PDF]

, 2012
BACKGROUND: The 'off-label' effect of alprazolam on depression has not been systematically evaluated.OBJECTIVES: To determine the antidepressant effect, including tolerability and acceptability, of alprazolam as monotherapy for major depression, when ...
Aden, American Psychiatric Association, American Psychiatric Association, American Psychiatric Association, Ansseau, Bandelow, Banerji, Barbone, Bassi, Beutler, Birkenhager, Borison, Ceskova, Committee on the Review of Medicines, Cropper, DerSimonian, Draper, Eriksson, Ettigi, Fabre, Fabre, Fawcett, Feighner, Feighner, Feighner, Fournier, Furukawa, Furukawa, Goldberg, Hamilton, Hansen, Hubain, Imlah, Jonas, Keller, Kirsch, Kravitz, Laakman, Laakmann, Lapierre, Lawrenson, Lenox, Lipman, Marwijk, Marwijk, Mendels, Moncrieff, Montgomery, Murthy, National Institute for Clinical Excellence (NICE), Neutel, Overall, Overall, Perri, Petty, Pitts, Pollack, Raskin, Remick, Remick, Rickels, Rickels, Rickels, Rickels, Rijswijk, Rimon, Rothblum, Rush, Schweizer, Schweizer, Sethy, Singh, Srisurapanont, Weissman, Weissman, World Health Organization, Zung   +76 more
core   +2 more sources

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, EarlyView.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Incontinência do choro e infarto protuberancial unilateral Incontinence of crying and unilateral pontine infarct

Arquivos de Neuro-Psiquiatria, 1995
O presente estudo trata do caso de um paciente que apresentou incontinência do choro e hemiplegia direita por infarto ventroprotuberancial paramediano detectado pela RNM.
Ricardo de Oliveira-Souza, Wagner Martignoni de Figueiredo, Pedro ângelo Andreiuolo   +2 more
doaj   +1 more source

Immunomodulatory effects of photodynamic therapy for skin cancer: Potential strategies to improve treatment efficacy and tolerability

Photochemistry and Photobiology, EarlyView.
Photodynamic therapy (PDT) is a nonscarring treatment modality that is widely used for skin cancers and early squamous precursor lesions. PDT was previously thought to work primarily by killing cancer cells directly (via apoptosis or necrosis). However, more recent work indicates that a significant mechanism for PDT is the stimulation of anti‐cancer ...
Mark P. Ortenzio, Sanjay Anand, Jeffrey B. Travers, Edward V. Maytin, Craig A. Rohan   +4 more
wiley   +1 more source

Completion rates of anterior and posterior continuous curvilinear capsulorrhexis in pediatric cataract surgery for surgery performed by trainee surgeons with the use of a low-cost viscoelastic

Indian Journal of Ophthalmology, 2012
Context : Pediatric cataract surgery is traditionally done with the aid of high-molecular-weight viscoelastics which are expensive. It needs to be determined if low-cost substitutes are just as successful.
R Muralidhar, G S Siddalinga Swamy, P Vijayalakshmi   +2 more
doaj   +1 more source