Results 51 to 60 of about 38,854 (250)

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Incontinência do choro e infarto protuberancial unilateral Incontinence of crying and unilateral pontine infarct

Arquivos de Neuro-Psiquiatria, 1995
O presente estudo trata do caso de um paciente que apresentou incontinência do choro e hemiplegia direita por infarto ventroprotuberancial paramediano detectado pela RNM.
Ricardo de Oliveira-Souza, Wagner Martignoni de Figueiredo, Pedro ângelo Andreiuolo   +2 more
doaj   +1 more source

Reasons for patient reluctance to take preventive medications for migraine: Results of the OVERCOME (US) study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This study was undertaken to evaluate patient reasons for nonadoption of migraine‐preventive medications. Despite clear recommendations and eligibility criteria for migraine‐preventive treatment by the American Headache Society and the availability of these treatments, many people with migraine are not taking appropriate ...
Jessica Ailani, Rose Okonkwo, Elizabeth Johnston, Helen Hochstetler, Betzaida Martinez, Anthony Zagar, Robert A. Nicholson, Bert B. Vargas, E. Jolanda Muenzel, Richard B. Lipton   +9 more
wiley   +1 more source

Completion rates of anterior and posterior continuous curvilinear capsulorrhexis in pediatric cataract surgery for surgery performed by trainee surgeons with the use of a low-cost viscoelastic

Indian Journal of Ophthalmology, 2012
Context : Pediatric cataract surgery is traditionally done with the aid of high-molecular-weight viscoelastics which are expensive. It needs to be determined if low-cost substitutes are just as successful.
R Muralidhar, G S Siddalinga Swamy, P Vijayalakshmi   +2 more
doaj   +1 more source

Alprazolam for depression [PDF]

, 2012
BACKGROUND: The 'off-label' effect of alprazolam on depression has not been systematically evaluated.OBJECTIVES: To determine the antidepressant effect, including tolerability and acceptability, of alprazolam as monotherapy for major depression, when ...
Aden, American Psychiatric Association, American Psychiatric Association, American Psychiatric Association, Ansseau, Bandelow, Banerji, Barbone, Bassi, Beutler, Birkenhager, Borison, Ceskova, Committee on the Review of Medicines, Cropper, DerSimonian, Draper, Eriksson, Ettigi, Fabre, Fabre, Fawcett, Feighner, Feighner, Feighner, Fournier, Furukawa, Furukawa, Goldberg, Hamilton, Hansen, Hubain, Imlah, Jonas, Keller, Kirsch, Kravitz, Laakman, Laakmann, Lapierre, Lawrenson, Lenox, Lipman, Marwijk, Marwijk, Mendels, Moncrieff, Montgomery, Murthy, National Institute for Clinical Excellence (NICE), Neutel, Overall, Overall, Perri, Petty, Pitts, Pollack, Raskin, Remick, Remick, Rickels, Rickels, Rickels, Rickels, Rijswijk, Rimon, Rothblum, Rush, Schweizer, Schweizer, Sethy, Singh, Srisurapanont, Weissman, Weissman, World Health Organization, Zung   +76 more
core   +2 more sources

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Pattern of outcome with sertraline, imipramine, and des-venlafaxine in unipolar nonpsychotic depression

Journal of Mental Health and Human Behaviour, 2015
Background: There is a scarcity of research on the temporal sequence of improvement with antidepressants and the differential effect of different antidepressants.
Abhishek Kapoor, Rohit Garg, Bir Singh Chavan, Paramleen Kaur   +3 more
doaj   +1 more source

Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse

Acta Neuropathologica Communications, 2023
In Alzheimer’s disease (AD), reactive astrocytes produce extracellular vesicles (EVs) that affect mitochondria in neurons. Here, we show that Aβ-induced generation of the sphingolipid ceramide by acid sphingomyelinase (A-SMase) triggered proinflammatory ...
Simone M. Crivelli, Zainuddin Quadri, Hemendra J. Vekaria, Zhihui Zhu, Priyanka Tripathi, Ahmed Elsherbini, Liping Zhang, Patrick G. Sullivan, Erhard Bieberich   +8 more
doaj   +1 more source

Modulation of Neurogenesis through the Promotion of Energy Production Activity Is behind the Antidepressant-Like Effect of Colonial Green Alga, Botryococcus braunii [PDF]

, 2017
Algae have been recognized as important resources providing functional components due to their capacity to exert beneficial effects on health. Therefore, there is increasing interest in investigating the biological activity of algae.
Demura Mikihide, Isoda Hiroko, Othman Mahmoud B., Sasaki Kazunori, Watanabe Makoto, 佐々木 一憲, 礒田 博子   +6 more
core   +1 more source