Results 51 to 60 of about 51,042 (305)

8-Cyclopentyl-1,3-dimethylxanthine enhances effectiveness of antidepressant in behavioral tests and modulates redox balance in the cerebral cortex of mice

Saudi Pharmaceutical Journal, 2018
The objective of our study was to investigate whether 8-cyclopentyl-1,3-dimethylxanthine (CPT), associated with the adenosine system, enhances the antidepressant efficacy of antidepressant. All experiments were carried out on Albino Swiss mice. Following
Mariola Herbet, Aleksandra Szopa, Anna Serefko, Sylwia Wośko, Monika Gawrońska-Grzywacz, Magdalena Izdebska, Iwona Piątkowska-Chmiel, Paulina Betiuk, Ewa Poleszak, Jarosław Dudka   +9 more
doaj   +1 more source

Serotonin reuptake inhibitors and cardiovascular disease [PDF]

, 2005
Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Belcher, P.R., Drake-Holland, A.J., Noble, M.   +2 more
core   +1 more source

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

Imipramine Administration in Brucella abortus 2308-Infected Mice Restores Hippocampal Serotonin Levels, Muscle Strength, and Mood, and Decreases Spleen CFU Count

Pharmaceuticals, 2023
Brucellosis infection causes non-specific symptoms such as fever, chills, sweating, headaches, myalgia, arthralgia, anorexia, fatigue, and mood disorders. In mouse models, it has been associated with increased levels of IL-6, TNF-α, and IFN-γ, a decrease
José Luis Maldonado-García, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, Samantha Alvarez-Herrera, Lenin Pavón, Luvia Sánchez-Torres, Gabriel Gutiérrez-Ospina, Manuel Iván Girón-Pérez, Gabriela Damian-Morales, Jesús Octavio Maldonado-Tapia, Rubén López-Santiago, Martha C. Moreno-Lafont   +11 more
doaj   +1 more source

Flexor Reflex Decreases during Sympathetic Stimulation in Chronic Human Spinal Cord Injury [PDF]

, 2009
A better understanding of autonomic influence on motor reflex pathways in spinal cord injury is important to the clinical management of autonomic dysreflexia and spasticity in spinal cord injured patients.
Garrison, Mark Kevin, Schmit, Brian D.
core   +2 more sources

Insights Into Patient‐Level Exposure to Actionable Pharmacogenomic Medications in Australia Using a New National Pharmacogenomic Guideline

Clinical Pharmacology &Therapeutics, EarlyView.
This study assessed the use of 35 pharmacogenomic (PGx) medications listed in the Royal College of Pathologists of Australasia (RCPA) guideline, estimated the potential costs of subsidizing PGx testing in Australia, and predicted related prescribing changes.
Bella D. Ianni, Chin Hang Yiu, Mohammad A. Ali, Christine Y. Lu   +3 more
wiley   +1 more source

Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression [PDF]

, 2017
Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of and recovery from depression ...
A Mateus-Pinheiro, A Mateus-Pinheiro, A Mateus-Pinheiro, A Sahay, A Surget, A Surget, AD Simons, B Czeh, BS McEwen, C Schmidt-Hieber, C Yang, EY Fenton, F Hardeveld, G Dagyte, GS Kirshenbaum, J Fuss, J Fuss, JL Onksen, JM Bessa, JM Bessa, JM Bessa, JY Kim, K McAlonan, K Sim, KG Akers, L Clark, L Santarelli, L Suo, MA Kheirbek, MN Jayatissa, N Kee, N Toni, P Patricio, P Willner, R Bisaz, RJ Baldessarini, RJ Boland, S Ge, SD Hollon, SM Southwick, SW Chan, TD Schmittgen, TI Mueller, YF Li, YH Hsiao, YI Sheline   +45 more
core   +1 more source

In Vitro Assessment of Drug‐Induced Liver Injury Using Three‐Dimensional Cultured HepaSH Cells Derived From Chimeric Mouse Model With Humanized Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Drug‐induced liver injury (DILI) is a serious adverse event and a common cause of postmarketing drug withdrawal. Despite nonclinical assessments of DILI risk, which are predominantly conducted in experimental animals, DILI remains a frequent adverse event, highlighting the need to improve nonclinical assessments.
Xingming Liu, Yuichiro Higuchi, Yuta Sakamoto, Shota Yanagida, Shotaro Uehara, Hiroshi Suemizu, Yasunari Kanda, Hiroyuki Kawagishi   +7 more
wiley   +1 more source

Imipramine in agoraphobia

Comprehensive Psychiatry, 1986
Abstract This article briefly and selectively reviews recent controlled trials of imipramine in agoraphobia. It is concluded that (1) imipramine enhances the effects of exposure treatments of agoraphobia probably due to facilitation of the process of habituation underlying repeated/prolonged exposure to phobic stimuli, (2) that imipramine doses in ...
openaire   +3 more sources

Administration of Harmine and Imipramine Alters Creatine Kinase and Mitochondrial Respiratory Chain Activities in the Rat Brain

Depression Research and Treatment, 2011
The present study evaluated mitochondrial respiratory chain and creatine kinase activities after administration of harmine (5, 10, and 15 mg/kg) and imipramine (10, 20, and 30 mg/kg) in rat brain.
G. Réus, R. Stringari, C. Gonçalves, G. Scaini, Milena Carvalho-Silva, Gabriela C. Jeremias, I. Jeremias, G. Ferreira, E. Streck, J. Hallak, A. Zuardi, J. Crippa, J. Quevedo   +12 more
semanticscholar   +1 more source