Results 61 to 70 of about 38,854 (250)

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, EarlyView.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Additive effects of trans-resveratrol and imipramine to reduce depressive symptoms in the forced swimming test in mice

مجله دانشگاه علوم پزشکی گرگان, 2016
Background and Objective: Resveratrol is a phenolic herbal compound which has been proposed as antioxidant in combinational therapy of diabetes, cancer and some neurodegenerative diseases.
R Ataee, AH Gitinavard, A Ataie, Y Nourian, M Shaterpour   +4 more
doaj  

Study of the β-Cyclodextrin Imipramine Hydrochloride Inclusion Complex and Determination of its Stability Constant (K) by UV-Visible Spectroscopy

E-Journal of Chemistry, 2007
In this research, the interactions of imipramine hydrochloride drug with β- cyclodextrin and the stability constant (K) of the inclusion complex formed between them were investigated by using UV-visible spectroscopy.
Alamdar Ashnagar, Nahid Gharib Naseri, Bita Khanaki   +2 more
doaj   +1 more source

Immunomodulatory effects of photodynamic therapy for skin cancer: Potential strategies to improve treatment efficacy and tolerability

Photochemistry and Photobiology, EarlyView.
Photodynamic therapy (PDT) is a nonscarring treatment modality that is widely used for skin cancers and early squamous precursor lesions. PDT was previously thought to work primarily by killing cancer cells directly (via apoptosis or necrosis). However, more recent work indicates that a significant mechanism for PDT is the stimulation of anti‐cancer ...
Mark P. Ortenzio, Sanjay Anand, Jeffrey B. Travers, Edward V. Maytin, Craig A. Rohan   +4 more
wiley   +1 more source

In vivo and in vitro effect of imipramine and fluoxetine on Na+,K+-ATPase activity in synaptic plasma membranes from the cerebral cortex of rats

Brazilian Journal of Medical and Biological Research, 2001
The effects of in vivo chronic treatment and in vitro addition of imipramine, a tricyclic antidepressant, or fluoxetine, a selective serotonin reuptake inhibitor, on the cortical membrane-bound Na+,K+-ATPase activity were studied.
L.M. Zanatta, F.C. Nascimento, S.V.T. Barros, G.R.R.S. Silva, A.I. Zugno, C.A. Netto, A.T.S. Wyse   +6 more
doaj   +1 more source

Possible involvement of keratinocyte‐derived microvesicle particles in human photosensitivity disorders

Photochemistry and Photobiology, EarlyView.
In this model, ROS generated by UVB result in PAFR agonists acting upon the PAFR resulting in MVP generation release via the enzyme aSMase. In photosensitivity, there are increased ROS, resulting in augmented PAF agonists and increased MVP release. This process can be blocked by aSMase inhibitors.
Risha Annamraju, Madison S. Owens, Anita Thyagarajan, Danielle A. Corbin, Catherine M. T. Sherwin, Jade Bryant, Garrett W. Fisher, Winston R. Owens, Alycia Ketter, Aadil Umerani, Craig A. Rohan, Michael G. Kemp, Robyn K. Crow, Jeffrey B. Travers   +13 more
wiley   +1 more source

Short-Course Treatment With Imipramine Entrapped in Squalene Liposomes Results in Sterile Cure of Experimental Visceral Leishmaniasis Induced by Antimony Resistant Leishmania donovani With Increased Efficacy

Frontiers in Cellular and Infection Microbiology, 2020
Previously we have shown that long term oral treatment of tricyclic-antidepressant-drug, imipramine, against experimental visceral leishmaniasis, results in clearance of organ parasites, regardless of input infection, either with antimony-sensitive (SbS)
Sandip Mukherjee, Supratim Pradhan, Souradeepa Ghosh, Shyam Sundar, Shantanabha Das, Budhaditya Mukherjee, Budhaditya Mukherjee, Syamal Roy, Syamal Roy   +8 more
doaj   +1 more source

Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence [PDF]

, 2011
Depression is a neuropsychiatric disorder affecting a huge percentage of the active population especially in developed countries. Research has devoted much of its attention to this problematic and many drugs have been developed and are currently ...
Berrocoso Domínguez, Esther María, Borges, Gisela, Micó Segura, Juan Antonio, Neto, Fani L., Torres-Sanchez, Sonia   +4 more
core   +4 more sources

Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Their bioactive constituents act through antioxidant, anti‐inflammatory, and metabolic‐regulating mechanisms, validating their classification as functional foods. Evidence from clinical and biochemical studies largely supports these benefits, although some claims stem from preliminary or in vitro findings.
Nighat Raza, Alina Sadaf, Reeha Mushtaq, Mirza Abid Mehmood, Luqman Amrao, Fakhar Islam, Muhammad Afzaal, Mohd Asif Shah   +7 more
wiley   +1 more source

Experimental Evidence for the Involvement of PDLIM5 in Mood Disorders in Hetero Knockout Mice [PDF]

, 2013
BackgroundReports indicate that PDLIM5 is involved in mood disorders. The PDLIM5 (PDZ and LIM domain 5) gene has been genetically associated with mood disorders; it’s expression is upregulated in the postmortem brains of patients with bipolar disorder ...
Arinami Tadao, Horiuchi Yasue, Iijima Yoshimi, Ishiguro Hiroki, Ishikawa Maya, Kaito Nobuko, Tanabe Yoshiko, 有波 忠雄, 飯嶋 良味   +8 more
core   +1 more source