Results 61 to 70 of about 51,042 (305)

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

Medicinal Research Reviews, EarlyView.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es   +3 more
wiley   +1 more source

α2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment [PDF]

, 2010
Slow-onset adaptive changes that arise from sustained antidepressant treatment, such as enhanced adult hippocampal neurogenesis and increased trophic factor expression, play a key role in the behavioral effects of antidepressants.
Bartlett, Perry, Fernandes, Kimberly, Hein, Lutz, Jha, Shanker, Jhaveri, Dhanisha, Ladiwala, Uma, Marathe, Swananda V., Muthig, Verena, Rommelfanger, Karen, Vadodaria, Krishna C., Vaidya, Vidita A., Weinshenker, David, Yanpallewar, Sudhirkumar U.   +12 more
core   +1 more source

Deep Eutectic Solvents in Polymeric Drug Carriers: Insights into Release Behavior and Functional Integration

ChemistryOpen, EarlyView.
Incorporating deep eutectic solvents into polymer‐based drug delivery systems (DDS) offers a sustainable route to enhance solubility, modify drug release, and create dual‐function carriers. This review explores how DES influence polymer structures and DDS performance, highlighting future prospects in personalized, responsive pharmaceutical technologies.
Nining Nining, Yoga Windhu Wardhana, Taofik Rusdiana, Hariyanti Hariyanti   +3 more
wiley   +1 more source

The Paroxetine 352 Bipolar Study Revisited: Deconstruction of Corporate and Academic Misconduct [PDF]

, 2019
Medical ghostwriting is the practice in which pharmaceutical companies engage an outside writer to draft a manuscript submitted for publication in the names of “honorary authors,” typically academic key opinion leaders.
Amsterdam, Jay D., McHenry, Leemon
core  

Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence [PDF]

, 2011
Depression is a neuropsychiatric disorder affecting a huge percentage of the active population especially in developed countries. Research has devoted much of its attention to this problematic and many drugs have been developed and are currently ...
Berrocoso Domínguez, Esther María, Borges, Gisela, Micó Segura, Juan Antonio, Neto, Fani L., Torres-Sanchez, Sonia   +4 more
core   +4 more sources

Drug‐facilitated crime: A review of findings between 2019 and 2023

Journal of Forensic Sciences, EarlyView.
Abstract Drug‐facilitated crime (DFC) is a criminal act (e.g., assault, robbery, or sexual assault) in which the perpetrator uses drugs to impair the victim's ability to resist, remember, or recognize the crime being committed. Ethanol is commonly implicated in DFC casework, but limited data are published on other substances currently implicated in ...
Meaghan R. Hessler, Sherri L. Kacinko, Barry K. Logan   +2 more
wiley   +1 more source

Efficacy and Acceptability of Licensed and Off‐Label Pharmacological Interventions for Insomnia in Patients With Severe Mental Illness: A Systematic Review and Meta‐Analysis of Randomised Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background A wide range of drugs is used to alleviate insomnia symptoms in individuals with severe mental illness (SMI), including licensed drugs and sedating drugs prescribed off‐label. Yet, no review has gathered the evidence on illness‐specific or transdiagnostic outcomes of pharmacological interventions for insomnia.
Nina Friis Bak Fuglsang, Nanna Marker Madsen, Søren Lundorff Jacobsen, Julie Eg Frøkjær, Nicolai Ladegaard, Marc Alberg Sørensen, Christoph U. Correll, Christian Otte, Mikkel Højlund, Ole Köhler‐Forsberg   +9 more
wiley   +1 more source

Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse

Acta Neuropathologica Communications, 2023
In Alzheimer’s disease (AD), reactive astrocytes produce extracellular vesicles (EVs) that affect mitochondria in neurons. Here, we show that Aβ-induced generation of the sphingolipid ceramide by acid sphingomyelinase (A-SMase) triggered proinflammatory ...
Simone M. Crivelli, Zainuddin Quadri, Hemendra J. Vekaria, Zhihui Zhu, Priyanka Tripathi, Ahmed Elsherbini, Liping Zhang, Patrick G. Sullivan, Erhard Bieberich   +8 more
doaj   +1 more source

Suicide Deaths in People With Bipolar Disorder: Characteristics and Treatments at Time of Death

Bipolar Disorders, EarlyView.
ABSTRACT Objectives This study aimed to compare suicide deaths in those with or without bipolar disorder (BD), taking into particular consideration the degree to which treatment at the time of death, according to toxicology data, reflects evidence‐based pharmacotherapy.
Ayal Schaffer, Prudence Po Ming Chan, Vera Yu Men, Rosalie Steinberg, Rachel HB. Mitchell, Gin Malhi, Lakshmi N. Yatham, Mark Sinyor   +7 more
wiley   +1 more source

Completion rates of anterior and posterior continuous curvilinear capsulorrhexis in pediatric cataract surgery for surgery performed by trainee surgeons with the use of a low-cost viscoelastic

Indian Journal of Ophthalmology, 2012
Context : Pediatric cataract surgery is traditionally done with the aid of high-molecular-weight viscoelastics which are expensive. It needs to be determined if low-cost substitutes are just as successful.
R Muralidhar, G S Siddalinga Swamy, P Vijayalakshmi   +2 more
doaj   +1 more source