Results 61 to 70 of about 49,920 (311)

Excited‐State Basicity Diverts the Site‐Selectivity of Aromatic Deuteration: Application to the Late‐Stage Labeling of Pharmaceuticals

Angewandte Chemie International Edition, EarlyView.
We present a metal‐free method for aromatic deuterium labeling via photoexcitation in deuterated HFIP. This approach leverages the enhanced basicity of excited‐state aromatics to achieve selective hydrogen isotope exchange at challenging positions. Demonstrated on complex drug molecules, this efficient strategy provides a valuable tool for isotope ...
Eva Rivera‐Chao, Javier Corpas, Giovanni Lonardi, Volker Derdau, Alessandro Ruffoni, Daniele Leonori   +5 more
wiley   +1 more source

A double blind, fixed blood-level study comparing mirtazapine with imipramine in depressed in-patients [PDF]

, 1996
Antidepressant effects of mirtazapine and imipramine were compared in a randomized, double blind, fixed blood-level study with in-patients in a single centre.
Broek, W.W. (Walter) van den, Bruijn, J.A. (Jan), Hulst, A.M. (A.) van, Mast, R.C. (Roos) van der, Moleman, P. (Peter), Mulder, P.G.H. (Paul), Wetering, B.J.M. (Ben) van de   +6 more
core   +1 more source

Imipramine in agoraphobia

Comprehensive Psychiatry, 1986
Abstract This article briefly and selectively reviews recent controlled trials of imipramine in agoraphobia. It is concluded that (1) imipramine enhances the effects of exposure treatments of agoraphobia probably due to facilitation of the process of habituation underlying repeated/prolonged exposure to phobic stimuli, (2) that imipramine doses in ...
openaire   +3 more sources

Imipramine treatment improves cognitive outcome associated with enhanced hippocampal neurogenesis after traumatic brain injury in mice.

Journal of Neurotrauma, 2011
Previous animal and human studies have demonstrated that chronic treatment with several different antidepressants can stimulate neurogenesis, neural remodeling, and synaptic plasticity in the normal hippocampus.
Xiaodi Han, Jing Tong, Jun Zhang, Arash Farahvar, Ernest W. Wang, Jiankai Yang, U. Samadani, Douglas H. Smith, Jason H. Huang   +8 more
semanticscholar   +1 more source

A systematic review of manipulations to pharmaceutical dosage forms used in psychotropic tapering plans

British Journal of Clinical Pharmacology, EarlyView.
Aims To identify, evaluate and summarize all published literature that investigated manipulations to pharmaceutical dosage forms of psychotropic medications that could be used for the purposes of tapering. Methods A systematic literature review was carried out of the available published literature on manipulations performed to psychotropic medications ...
Denis O'Brien, Anne Marie Healy, Andrew Harkin, Cathal Cadogan   +3 more
wiley   +1 more source

Imipramine as an alternative to formamide to detubulate rat ventricular cardiomyocytes [PDF]

, 2019
International audienceT-tubules are membrane invaginations essential for the excitation-contraction coupling (ECC). Imipramine like other cationic amphiphilic drugs, interfere with the PI(4,5)P2 interactions with proteins maintaining the tubular system ...
Barthe, Marion, Bedioune, Ibrahim, Bourcier, Aurelia, Fischmeister, Rodolphe, Lechêne, Patrick, Leroy, Jérôme, Miled, Hela Ben, Vandecasteele, Grégoire   +7 more
core   +3 more sources

Ethnomedicinal uses, phytochemistry, pharmacological activities, and toxicology of the subfamily Gomphrenoideae (Amaranthaceae): A comprehensive review

Chemistry &Biodiversity, Accepted Article.
The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its promising ...
Dayanna Isabel Araque Gelves, Giulia Cristina Andreoli de Souza, Alvaro Jose Hernandez Tasco, Marcos Jose Salvador   +3 more
wiley   +1 more source

In vivo and in vitro effect of imipramine and fluoxetine on Na+,K+-ATPase activity in synaptic plasma membranes from the cerebral cortex of rats

Brazilian Journal of Medical and Biological Research, 2001
The effects of in vivo chronic treatment and in vitro addition of imipramine, a tricyclic antidepressant, or fluoxetine, a selective serotonin reuptake inhibitor, on the cortical membrane-bound Na+,K+-ATPase activity were studied.
L.M. Zanatta, F.C. Nascimento, S.V.T. Barros, G.R.R.S. Silva, A.I. Zugno, C.A. Netto, A.T.S. Wyse   +6 more
doaj   +1 more source

Imipramine Administration in Brucella abortus 2308-Infected Mice Restores Hippocampal Serotonin Levels, Muscle Strength, and Mood, and Decreases Spleen CFU Count

Pharmaceuticals, 2023
Brucellosis infection causes non-specific symptoms such as fever, chills, sweating, headaches, myalgia, arthralgia, anorexia, fatigue, and mood disorders. In mouse models, it has been associated with increased levels of IL-6, TNF-α, and IFN-γ, a decrease
José Luis Maldonado-García, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, Samantha Alvarez-Herrera, Lenin Pavón, Luvia Sánchez-Torres, Gabriel Gutiérrez-Ospina, Manuel Iván Girón-Pérez, Gabriela Damian-Morales, Jesús Octavio Maldonado-Tapia, Rubén López-Santiago, Martha C. Moreno-Lafont   +11 more
doaj   +1 more source

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, EarlyView.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source