Results 101 to 110 of about 21,198 (196)

Practice Patterns in Extramammary Paget's Disease

JEADV Clinical Practice, Volume 5, Issue 3, Page 922-924, September 2026.
ABSTRACT Background In patients with Extramammary Paget's Disease (EMPD), a rare intraepithelial adenocarcinoma, wide local excision (WLE) has historically been the standard of treatment despite high rates of positive margins and recurrence. Mohs micrographic surgery (MMS) has demonstrated superior outcomes, yet practice patterns vary due to limited ...
Yasmine Mohseni, Olivia Burke, John Tsatalis, Clara Milikowski, Alyx Rosen Aigen   +4 more
wiley   +1 more source

Reviewing the use of imiquimod for molluscum contagiosum [PDF]

, 2018
We discuss imiquimod associated with non-application site mucosal reactions and two of our own clinical cases. In one of our patients, erosive cheilitis developed in a young boy after using topical imiquimod 5% cream for 5 nights weekly on bilateral ...
Pyle, Tia, Green, Justin J., DiBiagio, Jennifer R.   +2 more
core   +1 more source

METTL7A‐Dependent m6A Methylation Orchestrates CXCR4hi Neutrophil Pathogenicity and NETosis in Skin Inflammation

MedComm, Volume 7, Issue 9, September 2026.
In psoriasis, METTL7A is upregulated in aged CXCR4hi neutrophils, where it stabilizes PLSCR1 mRNA via m6A modification to enhance reactive oxygen species (ROS) production and neutrophil extracellular trap (NET) formation, thereby exacerbating disease severity.
Wanting Liu, Jinkai Liang, Huiyi Quan, Xuan Liu, Kang Li, Xin Tang, Jiaqi Wang, Yunfeng Gu, Yaxing Bai, Ke Xue, Zhiguo Li, Xiaolei Su, Erle Dang, Jiaoling Chen, Gang Wang, Shuai Shao   +15 more
wiley   +1 more source

SPR‐UPLC‐QTOF/MS‐GNPS‐Guided Discovery of Hypermonol J as a Novel Tumor Necrosis Factor‐Binding Small‐Molecule Lead for Inflammatory Storm Intervention

MedComm, Volume 7, Issue 9, September 2026.
SPR‐UPLC‐QTOF/MS‐GNPS‐guided screening identified hypermonol J (HPJ) as a high‐affinity TNF‐binding small molecule. HPJ may stabilize TNF dimers, reduce active trimer formation, and suppress TNFR1/NF‐κB signaling, thereby alleviating inflammatory pathology in psoriasis and acute lung injury models.
Yongqi Li, Weiguang Sun, Xingpiao Jin, Lanqin Li, Xiaotian Zhang, Pingping Fan, Yahui Huang, Chaohu Xiong, Jinsheng Wang, Jiangchun Wei, Yonghui Zhang, Zhengxi Hu   +11 more
wiley   +1 more source

Behandlungsoptionen für Molluscum contagiosum: Eine systematische Übersicht [PDF]

J Dtsch Dermatol Ges
Zusammenfassung Molluscum contagiosum (MC) ist eine virale Hautinfektion mit erheblichen physischen und psychosozialen Belastungen, die insbesondere bei Kindern und Personen mit geschwächtem Immunsystem auftritt. Obwohl mehrere Behandlungsoptionen zur Verfügung stehen, sind vergleichende Daten zu deren Wirksamkeit und Sicherheit begrenzt.
Wang O, Shergill M, Saed Aldien A, Mukovozov I.   +3 more
europepmc   +2 more sources

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source

Imiquimod en oncología cutánea

, 2017
El imiquimod tiene un mecanismo de acción interesante; al menos en Estados Unidos es popular y ampliamente prescrito, y muchos estudios reportan resultados favorables. Este agente no produce fotosensibilidad, su absorción percutánea es mínima, se excreta
García, Carlos
core  

Imiquimod: ett nytt potentiellt läkemedel för COVID19?

, 2020
BakgrundFör att tackla den rådande SARS-COV-2-pandemin har det ställts höga krav på en snabb utveckling och utvärdering av nya antivirala läkemedel.
Sverrild, Asger, Uller, Lena, Hvidtfeldt, Morten, Porsbjerg, Celeste, Cerps, Samuel, Tillgren, Sofia, Nieto Fontarigo, Juan José   +6 more
core  

The regulation of the PD-1/PD-L1 pathway in imiquimod-induced chronic psoriasis itch and itch sensitization in mouse

Molecular Pain
PD-1/PD-L1 inhibitors have been demonstrated to induce itch in both humans and experimental animals. However, whether the PD-1/PD-L1 pathway is involved in the regulation of chronic psoriatic itch remains unclear. This study aimed to investigate the role
Zhehao Xu, Yue Wang, Changcheng Jiang, Zhengwei Wang, YongFeng Cheng, Manli Fan   +5 more
doaj   +1 more source

Molecular Mechanisms and Therapeutic Applications of Extracellular Vesicles in Remodeling of the Skin Cancer Niche

Nano Select, Volume 7, Issue 9, September 2026.
Extracellular vesicles at the nexus of skin cancer progression and precision therapy. EVs orchestrate tumor microenvironment remodeling through cargo‐mediated intercellular communication, immune modulation, angiogenesis, and extracellular matrix reorganization, while also emerging as next‐generation platforms for targeted drug delivery, biomarker ...
Megha Kotian, Maria Nison, Deepanjan Datta, Soniya Kumbham, Namdev Dhas, Praveen Halagali, Vasudev R Pai, Vamshi Krishna Tippavajhala   +7 more
wiley   +1 more source