Results 61 to 70 of about 28,814 (216)

UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion [PDF]

, 2018
Toll‐like receptors (TLR) are critical mediators of the immune system with their activation linked to infection, inflammation and the pathogenesis of immune diseases including autoimmunity and cancer.
Beers, Boneparth, Butchar, Cheadle, Cho, Cleary, Dahal, Dahal, De Meyer, Donin, Fanti, Fits, Flutter, Gadd, Gilliet, Gordon, Isobe, Kuraoka, Lu, Oldfield, Rajan, Roghanian, Russo, Steinhagen, Tutt, Wu, Wu, Xue   +27 more
core   +1 more source

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source

TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections. [PDF]

, 2019
In mice, neonatally-developing, self-reactive B-1 cells generate steady levels of natural antibodies throughout life. B-1 cells can, however, also rapidly respond to infections with increased local antibody production. The mechanisms regulating these two
Baumgarth, Nicole, Baumgarth, Nicole, Baumgarth, Nicole, Baumgarth, Nicole, Kläsener, Kathrin, Luo, Zheng, Luo, Zheng, Luo, Zheng, Luo, Zheng, Reth, Michael, Savage, Hannah P, Savage, Hannah P, Savage, Hannah P, Savage, Hannah P, Smith, Fauna L, Smith, Fauna L, Smith, Fauna L, Smith, Fauna L   +17 more
core   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8⁺ T-cell responses in melanoma patients. [PDF]

, 2012
Optimal vaccine strategies must be identified for improving T-cell vaccination against infectious and malignant diseases. MelQbG10 is a virus-like nano-particle loaded with A-type CpG-oligonucleotides (CpG-ODN) and coupled to peptide(16-35) derived from ...
Bachmann, M.F., Baumgaertner, P., Dummer, R., Geldhof, C., Goldinger, S.M., Hammann-Haenni, A., Kündig, T.M., Michielin, O., Mihic-Probst, D., Prior, J.O., Schwarz, K., Speiser, D.E., Willers, J.   +12 more
core   +2 more sources

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, EarlyView.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

Erythema multiforme caused by topical imiquimod 3.75%

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2023
Imiquimod, 3.75% cream, is a topical immunomodulator approved for treating actinic keratoses. Although local side effects are more frequent, it can also have systemic side effects. We report that imiquimod 3.75% can also produce erythema multiforme (EM),
César Magalhães, André Coelho, Miguel Costa, Nuno Menezes   +3 more
doaj  

Basal cell carcinoma: 10-year experience with electrochemotherapy [PDF]

, 2017
BACKGROUND: Electrochemotherapy (ECT), by combining manageable cytotoxic agents with short electric pulses, represents an effective palliative skin-directed therapy.
Alaibac, MAURO SALVATORE ALESSANDRO, Campana, LUCA GIOVANNI, Galuppo, Sara, Marconato, Roberto, Mocellin, Simone, Rossi, CARLO RICCARDO, Valpione, Sara   +6 more
core   +2 more sources

Topical treatment of equine aural plaques with nitric acid and zinc solution

Equine Veterinary Journal, EarlyView.
Abstract Background Equine aural plaque caused by equine papilloma viruses is common worldwide and affected horses can show severe clinical signs. Due to its viral aetiology, in some countries affected horses are not allowed to compete. Since lesions persist, showing no spontaneous regression, effective and safe treatment is required.
Lii Katarina Leo, Kerstin Elisabet Bergvall   +1 more
wiley   +1 more source