Results 51 to 60 of about 29,009 (218)

Genital warts treatment: Beyond imiquimod

Human Vaccines & Immunotherapeutics, 2018
Genital warts are one of the most common sexually transmitted diseases worldwide. The disease is a result of infection with low-risk types of human papillomaviruses, mostly type 6 and 11.
Jianwei Yuan, Guoying Ni, Tianfang Wang, Kate Mounsey, Shelley Cavezza, Xuan Pan, Xiaosong Liu   +6 more
doaj   +1 more source

TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC trial): Study protocol for a randomized controlled trial [PDF]

, 2016
Background: Cervical intraepithelial neoplasia (CIN) is the premalignant condition of cervical cancer. Whereas not all high grade CIN lesions progress to cervical cancer, the natural history and risk of progression of individual lesions remain ...
Beekhuizen, H.J. (Heleen) van, Gerestein, C.G. (Kees), Gorp, T. (Toon) van, Hopman, A.H.N. (Anton), Koeneman, M.M. (Margot), Kooreman, L.F.S., Kruitwagen, R.F.M.P. (Roy), Kruse, A.J., Nijman, H.W. (Hans), Sep, S.J.S. (Simone), Slangen, A.H.L. (Arjen), van de Sande, M., Zur Hausen, A. (Axel)   +12 more
core   +5 more sources

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Imiquimod Reverses Chronic Toxoplasmosis-Associated Behavioral and Neurocognitive Anomalies in a Rat Model

Biomedicines
Toxoplasma gondii is the etiologic agent of toxoplasmosis, a highly prevalent parasitosis. Toxoplasma gondii (T. gondii) transits in the brain from acute (AT) to chronic toxoplasmosis (CT), under host immune control.
Shaymaa Itani, Maguy Hamie, Reem El Jammal, Wassim Abdine, Mark Doumit, Adib Charafeddine, Marwan El-Sabban, Cindy Patinote, Carine Masquefa, Pierre-Antoine Bonnet, Makram Obeid, Hiba El Hajj   +11 more
doaj   +1 more source

Vulvar vitiligo-like depigmentation and multiple halos of hypomelanosis at the trunk following treatment with imiquimod 5% cream for vulvar condylomata: casual or related events? [PDF]

Anais Brasileiros de Dermatologia, 2014
A 25-year-old Caucasian female with multiple genital warts involving the vulvar area was treated with imiquimod 5% cream. During follow-up the patient developed areas of hypopigmentation at the site of application of imiquimod cream and areas of ...
Maíra Chiarelli Serra, Claudia Menicanti, Elisabetta Pennacchioli, Giulio Tosti   +3 more
doaj   +1 more source

Treatment of recurrent mucosal melanoma of the oral cavity with topical imiquimod and pembrolizumab achieves complete histopathologic remission

Journal for ImmunoTherapy of Cancer, 2021
Mucosal melanomas constitute a subtype of melanoma with less effective treatments than cutaneous melanomas. We present a case of oral mucosal melanoma that recurred despite multiple resections and adjuvant temozolomide.
Richard Carvajal, Shaheer Khan, Tejus Satish, Matt Levin, Angela J Yoon   +4 more
doaj   +1 more source

UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion [PDF]

, 2018
Toll‐like receptors (TLR) are critical mediators of the immune system with their activation linked to infection, inflammation and the pathogenesis of immune diseases including autoimmunity and cancer.
Beers, Boneparth, Butchar, Cheadle, Cho, Cleary, Dahal, Dahal, De Meyer, Donin, Fanti, Fits, Flutter, Gadd, Gilliet, Gordon, Isobe, Kuraoka, Lu, Oldfield, Rajan, Roghanian, Russo, Steinhagen, Tutt, Wu, Wu, Xue   +27 more
core   +1 more source

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source

Evaluation of the Effect of Topical Artemisia dracunculus Administration on Serum Levels of Selected Interleukins and Spleen Index in Imiquimod-Induced Psoriasis in Male Mice Compared to Clobetasol Propionate (Dermovate (R)) Ointment

Iraqi Journal of Pharmaceutical Sciences, 2020
Psoriasis is a long-lasting autoimmune disease that is characterized by swollen skin patches. Normally, these skin patches are dark, swollen, itchy and scaly.
Thamer M. Mohammed, Shihab H. Mutlag, Bahaa A.Shihab   +2 more
doaj   +1 more source

Dysregulation of Amino Acid Transporters in a Rat Model of TLR7-Mediated Maternal Immune Activation

Pharmaceutics, 2023
Maternal immune activation (MIA) during pregnancy is linked to neurodevelopmental disorders in humans. Similarly, the TLR7 agonist imiquimod alters neurodevelopment in rodents.
Eliza R. McColl, Jeffrey T. Henderson, Micheline Piquette-Miller   +2 more
doaj   +1 more source