Results 51 to 60 of about 21,198 (196)

Oncoterapia dérmica con Imiquimod al 5% como alternativa al tratamiento de lesiones tumorales compatibles con sarcoide equino [PDF]

, 2017
Esta investigación consistió en determinar la eficacia del Imiquimod al 5 % en pequeñas lesiones tumorales compatibles con sarcoide equino, como una alternativa al tratamiento quirúrgico, utilizando Imiquimod en crema por un periodo de cuatro meses ...
Guerrero Salas, Omar Edwin
core  

Imiquimod: A Review

, 2002
Background and Objective: Imiquimod (Aldara) is an immune response modifier used primarily to treat anogenital warts. Imiquimod induces cytokines and enhances cell-mediated cytolytic antiviral activity in vivo. It exhibits antiviral and antitumor effects;
Melanie Browne, Aditya K. Gupta, Robyn Bluhm   +2 more
core   +1 more source

Evaluation of the Effect of Topical Artemisia dracunculus Administration on Serum Levels of Selected Interleukins and Spleen Index in Imiquimod-Induced Psoriasis in Male Mice Compared to Clobetasol Propionate (Dermovate (R)) Ointment

Iraqi Journal of Pharmaceutical Sciences, 2020
Psoriasis is a long-lasting autoimmune disease that is characterized by swollen skin patches. Normally, these skin patches are dark, swollen, itchy and scaly.
Thamer M. Mohammed, Shihab H. Mutlag, Bahaa A.Shihab   +2 more
doaj   +1 more source

Treatment of recurrent mucosal melanoma of the oral cavity with topical imiquimod and pembrolizumab achieves complete histopathologic remission

Journal for ImmunoTherapy of Cancer, 2021
Mucosal melanomas constitute a subtype of melanoma with less effective treatments than cutaneous melanomas. We present a case of oral mucosal melanoma that recurred despite multiple resections and adjuvant temozolomide.
Richard Carvajal, Shaheer Khan, Tejus Satish, Matt Levin, Angela J Yoon   +4 more
doaj   +1 more source

Topical treatment of equine aural plaques with nitric acid and zinc solution. [PDF]

Equine Vet J
Abstract Background Equine aural plaque caused by equine papilloma viruses is common worldwide and affected horses can show severe clinical signs. Due to its viral aetiology, in some countries affected horses are not allowed to compete. Since lesions persist, showing no spontaneous regression, effective and safe treatment is required.
Leo LK, Bergvall KE.
europepmc   +2 more sources

Type I interferon overactivation in sera of patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease

Rheumatology &Autoimmunity, EarlyView.
Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura, Yasuhiro Katsumata, Yuko Okamoto, Masayoshi Harigai   +3 more
wiley   +1 more source

Imiquimod induces apoptosis of human melanocytes.

, 2010
Development of vitiligo-like hypopigmentary lesions associated with topical imiquimod has been reported. We hypothesized that mode of action of imiquimod in melanocytes may include triggering of apoptosis resulted in loss of cells, which may be a ...
Joo Hee Ahn, Jung Hee Pyun, Kang, SU, Lee, MH, Pyun, JH, Chul-Ho Kim, Hye Sook Hwang, Mi Hye Lee, Ahn, JH, Hwang, HS, Sung Un Kang, Kim, CH, Hee Young Kang, Kang, HY   +13 more
core   +1 more source

Driving Drugs Deeper: Force‐Driven Microneedle Systems for Active Therapy and Their Road Towards Clinical Implementation

Small, EarlyView.
Force‐driven microneedles are presented as active therapeutic microdevices that overcome the diffusion limits of conventional patches. By integrating gas generation, magnetic actuation, cavitation, or iontophoresis, these systems drive payloads deeper into tissue, enabling faster, more controlled delivery and highlighting key design principles and ...
Majed Amini, Phoebe Li, Hamed Shahsavan, Mahla Poudineh   +3 more
wiley   +1 more source

Mcl-1 determines the imiquimod-induced apoptosis but not imiquimod-induced autophagy in skin cancer cells

, 2014
Background: Imiquimod had been shown to induce apoptosis and autophagy in several skin cancer cells, especially basal cell carcinoma (BCC) cells. Objective: We evaluate the molecular mechanisms of imiquimod-induced apoptosis and autophagy in skin cancer ...
Shieh, J.J., Wu, C.Y., Huang, S.W., Chang, C.C., Tsai, J.J., Liu, K.T., Chen, Y.J., Lin, C.C.   +7 more
core   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source