Results 61 to 70 of about 21,198 (196)

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma

Smart Molecules, EarlyView.
A brain‐targeting multifunctional nanoplatform (DM&Ce6@COF‐Ang) was engineered by employing boron‐enriched APTES‐COF‐1 as both the therapeutic boron agent and the nanocarrier co‐delivery of DMXAA and Ce6. This nanoplatform achieved synergistic tumor‐specific boron delivery, real‐time pharmacokinetic monitoring, and immunomodulation.
Yiming Liu, Xuejian Wang, Bangjian Li, Kun Shao, Jianlong Su, Yang Wang, Lin Cheng, Zhihao Wu, JinRong Li, Guanyi Zhang, Xu Wang, Yuxuan Zhang, Yuanhao Liu, Guangzhe Li   +13 more
wiley   +1 more source

Imiquimod-induced apoptosis of SCC12 cells.

, 2014
(A) Cells were treated with imiquimod at the indicated concentrations for 24 h. Cell viability was determined by MTT assay. Data are expressed as percentage of control (0 µg/ml imiquimod). The mean values ± SD are averages of triplicate measurements. (B)
Jae Woo Lim (553480), In-Kyu Chang (553481), Gang Min Hur (92907), Young Lee (101856), Jeung-Hoon Lee (101867), Kyung-Cheol Sohn (101793), Myung Im (101850), Tiejun Zhang (224265), Young-Joon Seo (101860), Dae-Kyoung Choi (101801), Chang Deok Kim (101864), Zheng Jun Li (469551)   +11 more
core   +1 more source

Prognostic markers in lentigo maligna patients treated with imiquimod cream: A long-term follow-up study. [PDF]

, 2016
BACKGROUND More data are needed to define factors that predict long-term success after imiquimod therapy for lentigo maligna (LM). OBJECTIVE We sought to determine the demographic, clinical, and histologic prognostic markers of relapse-free ...
Gautschi, Mirja, Gadaldi, Karolina, Hunger, Robert, Yawalkar, Nikhil, Oberholzer, Patrick Antony, Baumgartner, Marc   +5 more
core   +5 more sources

Monocytes Derived From Human Pluripotent Stem Cells Engineered for Detection of Pyrogens

Cell Proliferation, EarlyView.
In summary, we have developed a monocyte‐based reporter system using hESC‐Mono for interrogating the NF‐κB signalling axis, a central pathway governing pyrogenic responses. Our platform enables rapid and dose‐dependent detection of both endotoxins (LPS) and non‐endotoxins (LTA and Zymosan).
Jingjing Liu, Bingyu Cai, Tingting Gao, Wumei Wei, Liu Wang, Qi Zhou, Wei Li, Jie Hao, Jun Wu   +8 more
wiley   +1 more source

Depicting the Immunological Landscape of Basal Cell Carcinoma Subtypes

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Anti‐PD‐1 response has been associated with higher PD‐1 ligand (PD‐L1) expression levels in different cancer types. Cemiplimab, an anti‐PD‐1 antibody, has been shown to induce a response rate of 31% and 22% in patients with locally advanced basal cell carcinoma (BCC) and metastatic BCC respectively, who have progressed or are ...
Isabella Dommann, Gaetana Restivo, Isabel Kolm, Federica Sella, Patrick Turko, Phil F. Cheng, Mitchell Levesque, Corina Dommann‐Scherrer, Reinhard Dummer, Egle Ramelyte   +9 more
wiley   +1 more source

A single‐center prospective observational study evaluating the efficacy and safety of tirbanibulin 1% in actinic keratoses in immunosuppressed patients: the ESTIMATE study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Actinic keratoses (AKs) are common precursors to squamous cell carcinoma and pose a heightened risk in immunosuppressed patients, such as organ transplant recipients (OTRs). Patients and methods This prospective, monocentric, single‐arm observational study investigated the safety and efficacy of topical tirbanibulin 1% ointment in ...
Elisa Zavattaro, Federica Veronese, Vanessa Tarantino, Chiara Airoldi, Paola Savoia   +4 more
wiley   +1 more source

Attenuated Effects of Topical Empagliflozin on Imiquimod-induced Model of Psoriasis in Mice

Journal of Tropical Life Science
Empagliflozin is a sodium-glucose cotransporter inhibitor (SGLT2) that drops blood glucose levels by inhibiting glucose reabsorption and encouraging glucose excretion.
Alaa H. Abbas, Zahraa H Abbas, Hayder Ridha Salman, Hayder E Jabar, Abdulkareem H. Abd   +4 more
doaj   +1 more source

A Nodule on the Cheek of a Child

JEADV Clinical Practice, EarlyView.
Monika Fida, Tedi Minarolli, Ritjana Mala, Arlin Kokomani, Leart Bërdica, Alesja Palaj   +5 more
wiley   +1 more source

Understanding Exosomes in Hair Regeneration

Periodontology 2000, EarlyView.
Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice

Acta Dermato-Venereologica, 2017
The pathogenesis of psoriatic itch is poorly understood. The aim of this study was to investigate the involvement of opioid receptors in scratching behaviour of imiquimod-induced psoriasis-like dermatitis model mice.
Nobuaki Takahashi, Mitsutoshi Tominaga, Ryohei Kosaka, Yayoi Kamata, Yoshie Umehara, Hironori Matsuda, Azumi Sakaguchi, Hideoki Ogawa, Kenji Takamori   +8 more
doaj   +1 more source