Results 61 to 70 of about 29,009 (218)

5-hydroxymethylcytosine is a key epigenetic regulator of keratinocyte stem cells during psoriasis pathogenesis [PDF]

, 2019
Epigenetic regulation is now known to play an important role in determining stem cell fate during normal tissue development and disease pathogenesis. In this study, we report loss of 5-hydroxymethylcytosine (5-hmC) mediated by ten-eleven translocation ...
Yuan, Christine Wan-Yin
core  

Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis [PDF]

, 2019
Background More than 10 years have elapsed since human papillomavirus (HPV) vaccination was implemented. We did a systematic review and meta-analysis of the population-level impact of vaccinating girls and women against human ...
\uc9lodie, B\ue9nard, A Kahn, Jessica, A Machalek, Dorothy, A Smith, Megan, Ali, Hammad, Baldo, Vincenzo, Boily, MarcMarie\uadClaude, Brassard, Paul, Brisson,, Callander, Denton, Checchi, Marta, Cocchio, Silvia, Dalianis, Tina, Dehlendorff, Christian, Donovan, Basil, F Chow, Eric P, G Pollock, Kevin, Gr\ufcn, Nathalie, Harrison, Christopher, Herweijer, Eva, J Woestenberg, Petra, Jes\ufas Purri\uf1os\uadHermida, Mar\ueda, K Fairley, Christopher, K Kjaer, Susanne, Kavanagh, Kimberley, L Brotherton, Julia M, L Deeks, Shelley, Liu, Bette, M Garland, Suzanne, M Imburgia, Teresa, M Johnson, Anne, M Wheeler, Cosette, M\ue9lanie, Drolet, Markowitz, Lauri, Mesher, David, Munk, Christian, Niccolai, Linda, Norma, P\ue9rez, Nyg\ue5rd, Mari, Ogilvie, Gina, Oliphant, Jeannie, S\uf6derlund\uadStrand, Anna, Sonnenberg, Pam, Sparen, P\ue4r, Steben, Marc, T Hansen, Bo, Tanton, Clare, V Kliewer, Erich, W Flagg, Elaine, W Gargano, Julia, Yu., Bo Nancy   +50 more
core   +2 more sources

Spatial Cell Death and Oxidative Stress Dynamics in Gas Plasma‐Treated Tumor Tissues

Advanced NanoBiomed Research, EarlyView.
Schematic representation of the four experimental models to study tissue penetration and oxidation. Four tissue models were used. Human pancreatic cancer cells were grown on the chorioallantois membrane of chicken embryos and gas plasma‐treated in ovo, murine colorectal tumor tissue was gas plasma‐exposed ex vivo, murine squamous cell carcinoma cells ...
Anke Schmidt, Shahrzad Rokhsary, Linus Hübner, Lea Miebach, Sander Bekeschus   +4 more
wiley   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

Erythema multiforme caused by topical imiquimod 3.75%

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2023
Imiquimod, 3.75% cream, is a topical immunomodulator approved for treating actinic keratoses. Although local side effects are more frequent, it can also have systemic side effects. We report that imiquimod 3.75% can also produce erythema multiforme (EM),
César Magalhães, André Coelho, Miguel Costa, Nuno Menezes   +3 more
doaj  

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

Melanoma Arising after Imiquimod Use

Case Reports in Medicine, 2014
Imiquimod belongs to the class of 1H-imidazo-[4,5-c]quinolones—drugs originally developed as nucleoside analogues with the aim of finding new potential antiviral agents (Harrison et al., 1988).
Sharad P. Paul
doaj   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Topical treatment of equine aural plaques with nitric acid and zinc solution

Equine Veterinary Journal, EarlyView.
Abstract Background Equine aural plaque caused by equine papilloma viruses is common worldwide and affected horses can show severe clinical signs. Due to its viral aetiology, in some countries affected horses are not allowed to compete. Since lesions persist, showing no spontaneous regression, effective and safe treatment is required.
Lii Katarina Leo, Kerstin Elisabet Bergvall   +1 more
wiley   +1 more source