Results 71 to 80 of about 28,814 (216)
Melanoma Arising after Imiquimod Use
Case Reports in Medicine, 2014 Imiquimod belongs to the class of 1H-imidazo-[4,5-c]quinolones—drugs originally developed as nucleoside analogues with the aim of finding new potential antiviral agents (Harrison et al., 1988).
Sharad P. Paul
doaj +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.We calculated the infiltration profiles of 28 immune cells within psoriatic immune microenvironment through single‐sample gene set enrichment analysis (ssGSEA) algorithm based on the eleven psoriasis related microarray datasets. Five immune‐related genes CXCL8, CXCL9, CCL18, RGS1, and SAMSN1 are associated with psoriasis, and establish a predictive ...
Tingjin Zheng +7 more
wiley +1 more source
Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease
Journal of Periodontology, EarlyView.Abstract Background Emerging evidence supports a bidirectional link between periodontitis and inflammatory bowel disease (IBD). To investigate this relationship, experimental models commonly use dextran sodium sulfate (DSS) to induce colitis. However, DSS is presumed to selectively affect the colon, and its potential off‐target effects on the oral ...
Himanshi Tanwar +11 more
wiley +1 more source
Attenuated Effects of Topical Empagliflozin on Imiquimod-induced Model of Psoriasis in Mice
Journal of Tropical Life ScienceEmpagliflozin is a sodium-glucose cotransporter inhibitor (SGLT2) that drops blood glucose levels by inhibiting glucose reabsorption and encouraging glucose excretion.
Alaa H. Abbas +4 more
doaj +1 more source
Imiquimod-induced bullous pemphigoid: A case report
SAGE Open Medical Case Reports, 2023 A 72-year-old man treated with 3.5% imiquimod cream for scalp actinic keratoses developed the usual crusted and erosive reaction but developed bullae on the scalp, as well as the limbs and torso after several weeks into treatment.
Heidi Oi-Yee Li +2 more
doaj +1 more source
Induction of the members of Notch pathway in superficial basal cell carcinomas treated with imiquimod [PDF]
, 2018 Basal cell carcinoma of the skin (BCC) is the most common skin tumor in Caucasians worldwide. Different therapeutic options are available to treat BCC, including topical immunotherapy. Imiquimod is topical Toll-like receptor 7 agonist that activates anti-
Dummer, Reinhard +2 more
core
Systemic Absorption and Pharmacokinetics of Five Novel Topical Dermatologic Agents: A Review
JEADV Clinical Practice, EarlyView.ABSTRACT In recent years, innovative topical medications with novel mechanisms of action have emerged to treat common dermatologic conditions such as acne, atopic dermatitis, vitiligo, and actinic keratoses. These molecularly targeted therapies offer improved safety and tolerability compared to traditional options like corticosteroids.
Mary Dyson +4 more
wiley +1 more source
Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream
Journal of Translational Medicine, 2007 Background The objective of this study was to identify the molecular processes responsible for the anti-lesional activity of imiquimod in subjects with actinic keratosis using global gene expression profiling.
Raghavan Shalini +9 more
doaj +1 more source
Acta Dermato-Venereologica, 2017 The pathogenesis of psoriatic itch is poorly understood. The aim of this study was to investigate the involvement of opioid receptors in scratching behaviour of imiquimod-induced psoriasis-like dermatitis model mice.
Nobuaki Takahashi +8 more
doaj +1 more source
Targeting GLI factors to inhibit the Hedgehog pathway [PDF]
, 2015 Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer therapy because its aberrant activation is implicated in several cancers. Major progress has been made in the development of SMOOTHENED (SMO) antagonists, although
Alfonsi, Romina +4 more
core +2 more sources