Results 51 to 60 of about 457,939 (300)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Social Modulation of Imitation in Children with Autism Spectrum Disorder: Evidence from EEG and Reciprocal Imitation Training

open access: yesApplied Sciences
Imitation is crucial for social learning, yet children with autism spectrum disorder (ASD) often show atypical imitation abilities. To probe the neural dynamics that precede overt imitation, electroencephalography (EEG)—with a focus on α (8–12 Hz) and β (
Yonggu Wang   +3 more
doaj   +1 more source

Imitation and innovation in business environment

open access: yesProduction Engineering Archives, 2019
The main aim of this article is to demonstrate that in a dynamically changing business environment, an organization should focus on embracing imitation strategies such as a safer form of building up its market position.
Wierzbicki Michał, Nowodziński Paweł
doaj   +1 more source

Imitation from Observation: Learning to Imitate Behaviors from Raw Video via Context Translation

open access: yes, 2018
Imitation learning is an effective approach for autonomous systems to acquire control policies when an explicit reward function is unavailable, using supervision provided as demonstrations from an expert, typically a human operator.
Abbeel, Pieter   +3 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

TEXT-STYLISTIC REPLICATION AS A BASIC CATEGORY OF MODERN ADVERTISING

open access: yesВестник Кемеровского государственного университета, 2017
This article describes a special type of advertising texts characterized by a text-stylistic replication. This property of text implies an intentional imitation of the original source by preserving its typical distinctive feature that depends on the type
L. A. Isaeva   +2 more
doaj   +1 more source

PLAIDOYER POUR UN NOUVEAU MOMENT POLITIQUE EN RÉPUBLIQUE DÉMOCRATIQUE DU CONGO [PDF]

open access: yesCahiers Africains des Droits de l’Homme et de la Démocratie ainsi que du Développement Durable, 2022
La démocratie est un emprunt de la culture occidentale, elle ne peut faire évoluer les peuples africains. Seul le développement de sa propre culture, un développement adapté au sol, au climat et à la race, constitue pour chaque peuple un progrès ...
RUKENGWA BAHIZIRE N’SHAGI
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Proposing A Method for Assessment of Brand Imitation Factors

open access: yesAD-minister, 2019
Brand imitation is an approach for new brands to be successful in the market; on the other hand, it can be destructive for developed brands by incurring heavy financial losses. Many studies have investigated imitation and its effective factors.
Seyed Babak Ebrahimi   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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