Results 51 to 60 of about 36,564 (266)

Prospects of business process management based on chatbots [PDF]

open access: yesProblems and Perspectives in Management
The relevance of the study is due to the growing need to use chatbots to optimize business processes. The purpose is to form a theoretical basis and practical tools for increasing the efficiency of using chatbots in business processes.
Leonid Melnyk   +5 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Traductions de théâtre ou trahison théâtrale : l'imitation renaissante comme appropriation culturelle

open access: yesCarnets, 2018
Published in 1579, the collection of the Six Premières Comédies facécieuses by Pierre de Larivey sets him as the most prolific comic playwright of the 16th century.
Anne Rogé
doaj   +1 more source

Mimetic effect in mentoring: the contribution of shared transcendence values [PDF]

open access: yesInternational Journal of Evidence Based Coaching and Mentoring, 2019
Modelling in mentoring has been widely identified but the underlying mimetic process of how mentor qualities are reproduced in mentees is rarely explained. This article describes how a critical realist mixed methods case-study of Baptist ministers led to
Colin Norris
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

“But how then shall I imitate thee, and/ Copie thy fair, though bloudie hand?”(“The Thanksgiving”, vv.15-16)

open access: yesSillages Critiques, 2012
Herbert first imitates God’s Word. His Temple is deliberately built almost exclusively on the Bible, which it quotes or glosses extensively. Second, the work belongs to the rich tradition of the imitation of Christ, which was still popular in the early ...
Guillaume Coatalen
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

The Source of Palm Orientation Errors in the Signing of Children with ASD: Imitative, Motoric, or Both?

open access: yesBrain Sciences, 2020
Palm orientation reversal errors (e.g., producing the ‘bye-bye’ gesture with palm facing inward rather than outward as is customary in American culture) have been documented in the signing of deaf and hearing children with autism spectrum disorder (ASD ...
Aaron Shield   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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