Results 71 to 80 of about 82,167 (312)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Entrepreneurial orientation and the threat of imitation: the influence of upstream and downstream capabilities [PDF]
, 2013 This paper uncovers the complexity between Entrepreneurial Orientation (EO) and performance. The paper explores the effect of the threat of imitation, which is a key external factor to explain competitive dynamics, and hence highlights effectiveness of ...
Canales, J.I. +2 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Brain Sciences, 2020 Palm orientation reversal errors (e.g., producing the ‘bye-bye’ gesture with palm facing inward rather than outward as is customary in American culture) have been documented in the signing of deaf and hearing children with autism spectrum disorder (ASD ...
Aaron Shield +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Attention modulates the specificity of automatic imitation to human actors
, 2009 The perception of actions performed by others activates one’s own motor system. Recent studies disagree as to whether this effect is specific to actions performed by other humans, an issue complicated by differences in perceptual salience between human ...
Longo, Matthew R., Bertenthal, B.I.
core +1 more source
Is automatic imitation a specialized form of stimulus–response compatibility? Dissociating imitative and spatial compatibilities [PDF]
, 2012 In recent years research on automatic imitation has received considerable attention because it represents an experimental platform for investigating a number of inter-related theories suggesting that the perception of action automatically activates ...
Longo, Matthew R. +2 more
core +1 more source
Les Salons de Diderot : une chronique de la création artistique
Carnets, 2014 The Salons of Diderot are directed to a foreign audience who cannot visit these French artistic events. The audience is as much concrete as abstract instances, fundamental component of this work which is at the same time an aesthetic judgment and a ...
Ana Fernandes
doaj +1 more source
The analysis of respiratory reactions of the person in the conditions of the changed gas environment on mathematical model [PDF]
Компьютерные исследования и моделирование, 2017 The aim of the work was to study and develop methods of forecasting the dynamics of the human respiratory reactions, based on mathematical modeling. To achieve this goal have been set and solved the following tasks: developed and justified the overall ...
Timofey V. Matjushev +1 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source