Results 71 to 80 of about 35,244 (265)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Les Salons de Diderot : une chronique de la création artistique
Carnets, 2014 The Salons of Diderot are directed to a foreign audience who cannot visit these French artistic events. The audience is as much concrete as abstract instances, fundamental component of this work which is at the same time an aesthetic judgment and a ...
Ana Fernandes
doaj +1 more source
The analysis of respiratory reactions of the person in the conditions of the changed gas environment on mathematical model [PDF]
Компьютерные исследования и моделирование, 2017 The aim of the work was to study and develop methods of forecasting the dynamics of the human respiratory reactions, based on mathematical modeling. To achieve this goal have been set and solved the following tasks: developed and justified the overall ...
Timofey V. Matjushev +1 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Identiques et différentes – à propos des répétitions dans Madame Bovary
Flaubert: Revue Critique et Génétique, 2018 Based on the analysis of an identical sentence (« son père l’amena lui-même ») which has been repeated, under different circumstances and with another meaning, about Charles as well as about Emma, this article has the purpose to measure on several levels
Shiguéhiko Hasumi
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Cahiers d’Études Romanes, 2001 La pratique citationnelle est courante, au XVIIe siècle, au sein des académies, et le monde académique en étudie les mécanismes. Cet article centre son propos sur les témoignages de deux érudits, Giuseppe Malatesta Garufi (Rimini) et Bartolomeo Dotti ...
Claire Vovelle-Guidi
doaj +1 more source
Current Opinion in Chemical Biology, 2012 Synthetic biologists typically construct new pathways within existing cells. While useful, this approach in many ways ignores the undefined but necessary components of life. A growing number of laboratories have begun to try to remove some of the mysteries of cellular life by building life-like systems from non-living component parts.
Forlin, Michele +2 more
openaire +5 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source