Results 61 to 70 of about 36,564 (266)
Current Opinion in Chemical Biology, 2012 Synthetic biologists typically construct new pathways within existing cells. While useful, this approach in many ways ignores the undefined but necessary components of life. A growing number of laboratories have begun to try to remove some of the mysteries of cellular life by building life-like systems from non-living component parts.
Forlin, Michele +2 more
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Les Salons de Diderot : une chronique de la création artistique
Carnets, 2014 The Salons of Diderot are directed to a foreign audience who cannot visit these French artistic events. The audience is as much concrete as abstract instances, fundamental component of this work which is at the same time an aesthetic judgment and a ...
Ana Fernandes
doaj +1 more source
The analysis of respiratory reactions of the person in the conditions of the changed gas environment on mathematical model [PDF]
Компьютерные исследования и моделирование, 2017 The aim of the work was to study and develop methods of forecasting the dynamics of the human respiratory reactions, based on mathematical modeling. To achieve this goal have been set and solved the following tasks: developed and justified the overall ...
Timofey V. Matjushev +1 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Identiques et différentes – à propos des répétitions dans Madame Bovary
Flaubert: Revue Critique et Génétique, 2018 Based on the analysis of an identical sentence (« son père l’amena lui-même ») which has been repeated, under different circumstances and with another meaning, about Charles as well as about Emma, this article has the purpose to measure on several levels
Shiguéhiko Hasumi
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Cahiers d’Études Romanes, 2001 La pratique citationnelle est courante, au XVIIe siècle, au sein des académies, et le monde académique en étudie les mécanismes. Cet article centre son propos sur les témoignages de deux érudits, Giuseppe Malatesta Garufi (Rimini) et Bartolomeo Dotti ...
Claire Vovelle-Guidi
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Kybernetes, 2010 This issue of the Kybernetes journal is concerned with the philosophical question Can a Machine Think? Famously, in his 1950 paper ‘Computing Machinery and Intelligence’ [11], the British mathematician Alan Turing suggested replacing this question which he found “too meaningless to deserve discussion” with a simple [behaviourial] test based on an ...
openaire +1 more source