Results 41 to 50 of about 237,408 (289)

Investigating the thrombopoietic significance of preplatelet maturation in health and acquired thrombocytopenia [PDF]

, 2021
Circulating “preplatelets” (3-10μm in diameter) are platelet precursors that mature by transforming into barbell platelets and can undergo fission into two smaller platelets (2-3μm in diameter).
Kemble, Samuel
core   +4 more sources

Immature platelet fraction in cardiology

Clinica Chimica Acta
Cardiovascular diseases (CVDs) remain a leading global cause of mortality, necessitating biomarkers that enhance risk stratification and therapeutic personalization. The Immature Platelet Fraction (IPF), representing young, RNA-rich platelets (also known as reticulated platelets, RP) released from bone marrow, has emerged as a dynamic biomarker linking
Zhao, Cao, Hamed, Soleimani Samarkhazan
openaire   +2 more sources

Comparison of an Immature Platelet Fraction and Reticulated Platelet in Liver Cirrhosis

Annals of Laboratory Medicine, 2007
The main causes of thrombocytopenia in cirrhosis are thought to be platelet destruction and the reduction of thrombopoietin (TPO) expression in the liver. Immature platelet fraction (IPF) has been measured by a fully automated analyzer (Sysmex XE-2100, Japan) as reticulated platelet (RP), which is reflected with thrombopoiesis in bone marrow.
Hye Ryoun, Kim, Bo Rae G, Park, Mi Kyung, Lee, Ae Ja, Park, Jeong Yeal, Ahn   +4 more
openaire   +2 more sources

An Analysis of Immature Platelet Fraction Values

Blood, 2021
Abstract Introduction Immune thrombocytopenia (ITP) in children typically manifests with acute, severe thrombocytopenia leading to variable mucocutaneous and tissue bleeding. Despite gaining insight into disease biology, there is no confirmatory diagnostic test, leaving the clinician to exclude other causes of ...
Cicely Conway, Amanda B Grimes, Jenny M. Despotovic, Susan E Kirk, Taylor Olmsted Kim, Xiaofan Huang, Charles Minard   +6 more
openaire   +1 more source

Immature Platelet Fraction in Thrombocytopenic Patients

Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI), 2021
Bone marrow puncture (BMP), is usually performed to identify thrombopoiesis activity and is still the gold standard to determine the etiology of thrombocytopenia. This diagnostic test is invasive hence it may cause discomfort to the patient. One of noninvasive test to determine the etiology of thrombocytopenia is by measuring immature platelet fraction
Dwita Sinaga, Dairion Gatot
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage. [PDF]

PLoS ONE, 2014
Circulating immature platelet fraction (IPF) reflects real-time thrombopoiesis and correlates with platelet recovery from thrombocytopenic presentations.
Hong Hong, Wenbin Xiao, Robert W Maitta
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Flow cytometric analysis of platelet cyclooxygenase-1 and -2 and surface glycoproteins in patients with immune thrombocytopenia and healthy individuals

Platelets, 2017
Immature platelets may contain more platelet enzymes such as cyclooxygenase (COX)-1 and COX-2 than mature platelets. Patients with immune thrombocytopenia (ITP) have a higher fraction of immature platelets and can therefore be utilized as a biological ...
Peter Rubak, Steen D. Kristensen, Anne-Mette Hvas   +2 more
doaj   +1 more source

Platelet kinetics in the pulmonary microcirculation in vivo assessed by intravital microscopy [PDF]

, 2002
Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet.
Eichhorn, M. E., Ney, L., Massberg, S., Goetz, Alwin Eduard, Eichhorn, M. E.;Ney, L.;Massberg, S.;Goetz, A. E.   +4 more
core   +1 more source