Results 101 to 110 of about 75,693 (242)
LifeCells are very important to researchers due to their use in various biological studies in in vitro and in vivo settings. This importance stems from the short lifespan of most cells under laboratory conditions, which can pose significant challenges, such ...
Mahla Chalak +6 more
doaj +1 more source
Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization
Nucleic Acids Research, 2012 Progression to malignancy requires that cells overcome senescence and switch to an immortal phenotype. Thus, exploring the genetic and epigenetic changes that occur during senescence/immortalization may help elucidate crucial events that lead to cell ...
S. Tommasi +7 more
semanticscholar +1 more source
Optimized for routine: highly sensitive fluorescent Telomeric Repeat Amplification Protocol (f-TRAP)
BioTechniquesThe strict suppression of telomerase activity (TA) in terminally differentiated human cells causes a shortening of the chromosome ends after each cell division.
Silke Fähnrich +3 more
doaj +1 more source
Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization [PDF]
, 2015 The use of time series profiling to identify groups of functionally related genes (synexpression groups) is a powerful approach for the discovery of gene function. Here we apply this strategy during RasV12 immortalization of Drosophila embryonic cells, a
Dequeant, M. L. +6 more
core +1 more source
Primary culture and immortalization of human fallopian tube secretory epithelial cells.
Nature Protocols, 2012 Primary human fallopian tube secretory epithelial cell (FTSEC) cultures are useful for studying normal fallopian tube epithelial biology, as well as for developing models of fallopian tube disease, such as cancer.
Alison M. Karst, R. Drapkin
semanticscholar +1 more source
Amlexanox Enhances Premature Termination Codon Read-Through in COL7A1 and Expression of Full Length Type VII Collagen: Potential Therapy for Recessive Dystrophic Epidermolysis Bullosa. [PDF]
, 2017 Recessive dystrophic epidermolysis bullosa (RDEB) is a rare monogenic blistering disorder caused by the lack of functional type VII collagen, leading to skin fragility and subsequent trauma-induced separation of the epidermis from the underlying dermis ...
Atanasova, Velina S. +10 more
core +1 more source
Journal of the American College of Cardiology, 2010 ![Figure][1] Although immortality is, I guess, one of the ultimate goals of medicine, no human has thus far achieved it, nor is anyone likely to do so for the foreseeable future. However, the same is not true for human tissue.
openaire +2 more sources
Neoplasia: An International Journal for Oncology Research, 2015 Our recent study showed that SAG/RBX2 E3 ubiquitin ligase regulates apoptosis and vasculogenesis by promoting degradation of NOXA and NF1, and co-operates with Kras to promote lung tumorigenesis by activating NFκB and mTOR pathways via targeted ...
Mingjia Tan, Hua Li, Yi Sun
doaj +1 more source
Establishment and Characterization of SV40 T-Antigen Immortalized Porcine Muscle Satellite Cell
CellsMuscle satellite cells (MuSCs) are crucial for muscle development and regeneration. The primary pig MuSCs (pMuSCs) is an ideal in vitro cell model for studying the pig’s muscle development and differentiation.
Mengru Ni +10 more
doaj +1 more source