Results 81 to 90 of about 75,693 (242)
Establishment and characterization of two human breast carcinoma cell lines by spontaneous immortalization: Discordance between Estrogen, Progesterone and HER2/neu receptors of breast carcinoma tissues with derived cell lines [PDF]
, 2012 Background: Breast cancer is one of the most common cancers among women throughout the world. Therefore, established cell lines are widely used as in vitro experimental models in cancer research.Methods: Two continuous human breast cell lines, designated
Akmal, S.N. +6 more
core +1 more source
HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes. [PDF]
PLoS Pathogens, 2013 Previous studies have shown that wild-type human telomerase reverse transcriptase (hTERT) protein can functionally replace the human papillomavirus type 16 (HPV-16) E6 protein, which cooperates with the viral E7 protein in the immortalization of primary ...
Jonathan Miller +7 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2019 Porcine circovirus 2 (PCV2) is a major etiological agent for porcine circovirus-associated diseases and causes enormous economic losses in domestic and overseas swine production.
Hongjie Cui +4 more
doaj +1 more source
Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer [PDF]
, 2014 Runt domain transcription factor 3 (RUNX3) is widely regarded as a tumour-suppressor gene inactivated by DNA hypermethylation of its canonical CpG (cytidine-phosphate-guanidine) island (CGI) promoter in gastric cancer (GC).
Fox, James G +8 more
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Animal Models and Experimental MedicineBackground A stable and standardized source of mesenchymal stem cells is a prerequisite for bone repair tissue engineering research and application. We aimed to establish a stable cell line of bone marrow mesenchymal stem cells from New Zealand rabbits ...
Yao Zhang +6 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2014 Although noncancerous immortalized cell lines have been developed by introducing genes into human and murine somatic cells, such cell lines have not been available in large domesticated animals like pigs.
JoonHo Moon +6 more
doaj +1 more source
Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]
, 1993 The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Alexander L. Gerbes +40 more
core +1 more source
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization.
Genes & Development, 2000 The retinoblastoma protein, pRB, and the closely related proteins p107 and p130 are important regulators of the mammalian cell cycle. Biochemical and genetic studies have demonstrated overlapping as well as distinct functions for the three proteins in ...
J. Sage +7 more
semanticscholar +1 more source