Results 71 to 80 of about 75,693 (242)

Cytogenetic features of human trophoblast cell lines SWAN-71 and 3A-subE [PDF]

, 2017
Immortalization of primary cells with telomerase is thought to maintain normal phenotypic properties and avoid chromosomal abnormalities and other cancer-associated changes that occur following simian virus 40 tumor antigen (SV40 Tag) induced ...
Chakraborty, Sujata, Drendel, Holli M., Lee, Men-Jean, Mor, Gil, Reiter, Jill L., Schellinger, Megan M.   +5 more
core   +1 more source

Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations

Cell Cycle, 2014
Telomerase reactivation and immortalization are critical for human carcinoma progression. However, little is known about the mechanisms controlling this crucial step, due in part to the paucity of experimentally tractable model systems that can examine ...
J. Garbe, L. Vrba, Klara Sputova, Laura Fuchs, P. Novák, A. Brothman, M. Jackson, K. Chin, Mark A. LaBarge, G. Watts, B. Futscher, M. Stampfer   +11 more
semanticscholar   +1 more source

The Research Progress on Immortalization of Human B Cells

Microorganisms, 2023
Human B cell immortalization that maintains the constant growth characteristics and antibody expression of B cells in vitro is very critical for the development of antibody drugs and products for the diagnosis and bio-therapeutics of human diseases ...
Huiting Xu, Xinxin Xiang, Weizhe Ding, Wei Dong, Yihong Hu   +4 more
doaj   +1 more source

Extremely stringent activation of p16INK4a prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression [PDF]

, 2016
published_or_final_versio
Cheung, A, Deng, W, Ngan, HYS, Su, H, Tiwari, AFY, Tsao, GSW, Yip, YL   +6 more
core   +2 more sources

Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. [PDF]

, 2017
BackgroundProper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for pubertal onset and reproduction. To further our understanding of the molecular events taking place during embryonic development, leading to ...
Brayman, Melissa J, Hoffmann, Hanne M, Iyer, Anita K, Mellon, Pamela L, Ngo, Cindy, Sunshine, Mary Jean, Xie, Huimin   +6 more
core   +3 more sources

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

Journal of Translational Medicine, 2011
BackgroundExosomes or secreted bi-lipid vesicles from human ESC-derived mesenchymal stem cells (hESC-MSCs) have been shown to reduce myocardial ischemia/reperfusion injury in animal models. However, as hESC-MSCs are not infinitely expansible, large scale
T. Chen, F. Arslan, Yijun Yin, S. S. Tan, R. C. Lai, A. Choo, J. Padmanabhan, C. Lee, D. D. de Kleijn, S. Lim   +9 more
semanticscholar   +1 more source

TrAmplification of Human Dental Follicle Cells by piggyBac Transposon - Mediated Reversible Immortalization System. [PDF]

PLoS ONE, 2015
Dental follicle cells (DFCs) are the precursor cells of periodontium. Under certain differentiation conditions, DFCs can be induced to differentiate into chondrogenic, osteogenic and adipogenic cells.
Yan Wu, Ge Feng, Jinlin Song, Yuanyuan Zhang, Yong Yu, Lan Huang, Leilei Zheng, Feng Deng   +7 more
doaj   +1 more source

The Russian Artist in Plato's Republic [PDF]

, 2013
In Book 10 of the Republic, Plato launches an extensive critique of art, claiming that it can have no legitimate role within the well-ordered state. While his reasons are multifac- eted, Plato’s primary objection to art rests on its status as a mere ...
Michelle, Panchuk
core  

Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]

, 2005
Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Huss, R., Hutter, J., Krombach, F., Moosmann, S., Moser, C.   +4 more
core   +1 more source

Establishment of primary prostate epithelial and tumorigenic cell lines using a non-viral immortalization approach

Biological Research
Background Research on prostate cancer is mostly performed using cell lines derived from metastatic disease, not reflecting stages of tumor initiation or early progression.
Simon Lange, Anna Kuntze, Neele Wüstmann, Theresa Reckers, Verena Humberg, Wilhelm G. Dirks, Sebastian Huss, Julia Vieler, Andres Jan Schrader, Martin Bögemann, Katrin Schlack, Christof Bernemann   +11 more
doaj   +1 more source