Results 51 to 60 of about 75,693 (242)

Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring. [PDF]

, 2019
The new and rapid advancement in the complexity of biologics drug discovery has been driven by a deeper understanding of biological systems combined with innovative new therapeutic modalities, paving the way to breakthrough therapies for previously ...
Chen, Ching, Chen, Irwin, Chong, Su, Hamburger, Agi, Jess, Philip, Jorgolli, Marsela, Le, Kim, Lin, Fen-Fen, Miranda, Les P, Mock, Marissa, Munro, Trent, Nevill, Tanner, Stevens, Jennitte, Tagari, Philip, Tan, Christopher, Winters, Aaron, Wu, Ming, Xu, Han   +17 more
core   +1 more source

Immortalization capacity of HPV types is inversely related to chromosomal instability

OncoTarget, 2016
High-risk human papillomavirus (hrHPV) types induce immortalization of primary human epithelial cells. Previously we demonstrated that immortalization of human foreskin keratinocytes (HFKs) is HPV type dependent, as reflected by the presence or absence ...
Denise M. Schütze, O. Krijgsman, P. Snijders, B. Ylstra, Joachim Weischenfeldt, Balca R. Mardin, Adrian M. Stütz, Jan O. Korbel, J. D. de Winter, C. J. Meijer, W. Quint, Leontien Bosch, S. M. Wilting, R. Steenbergen   +13 more
semanticscholar   +1 more source

Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]

, 2002
International ...
Burdon, Tom, Savatier, Pierre, Smith, Austin   +2 more
core   +1 more source

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

Nature, 2009
The overexpression of defined transcription factors in somatic cells results in their reprogramming into induced pluripotent stem (iPS) cells. The extremely low efficiency and slow kinetics of in vitro reprogramming suggest that further rare events are ...
J. Utikal, J. Polo, M. Stadtfeld, Nimet Maherali, Warakorn Kulalert, R. Walsh, A. Khalil, J. Rheinwald, K. Hochedlinger   +8 more
semanticscholar   +1 more source

The Immortality of Infusoria [PDF]

Monist, 1890
n ...
openaire   +2 more sources

Afterword: New immortalities? [PDF]

Medicine Anthropology Theory, 2020
n ...
Simpson, Bob, Douglas-Jones, Rachel
openaire   +4 more sources

Immortalization of Primary Keratinocytes and Its Application to Skin Research

Biomolecules & Therapeutics, 2015
As a major component of the epidermal tissue, a primary keratinocyte has served as an essential tool not only for the study of pathogenesis of skin-related diseases but also for the assessment of potential toxicities of various chemicals used in ...
M. Choi, Choongho Lee
semanticscholar   +1 more source

Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers

BMC Biotechnology, 2011
Background The strenuous procurement of cultured human hepatocytes and their short lives have constrained the cell culture model of cytochrome P450 (CYP450) induction, xenobiotic biotransformation, and hepatotoxicity.
Limsrichamrern Somchai, Akarasereenont Pravit, Borwornpinyo Suparerk, Nuntakarn Lalana, Duangsa-ard Sunisa, Kasetsinsombat Kanda, Wongkajornsilp Adisak, Sa-ngiamsuntorn Khanit, Hongeng Suradej   +8 more
doaj   +1 more source

Developmental and tissue-specific regulation of mouse telomerase and telomere length [PDF]

, 1995
Telomere shortening and telomerase activation in human somatic cells have been implicated in cell immortalization and cellular senescence. To further study the role of telomerase in immortalization, we assayed telomere length and telomerase activity in ...
Prowse, K. R., Greider, C. W.
core   +1 more source

Immortalization of American miniature horse-derived fibroblast by cell cycle regulator with normal karyotype [PDF]

PeerJ
Immortalized cells serve as a crucial research tool that capitalizes on their robust proliferative properties for functional investigations of an organism. Establishing an immortalized American miniature horse cell line could yield valuable insights into
Tetsuya Tani
doaj   +2 more sources