Results 61 to 70 of about 75,693 (242)

Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. [PDF]

, 2017
Copy number alteration (CNA) profiling of human tumors has revealed recurrent patterns of DNA amplifications and deletions across diverse cancer types.
Balanis, Nikolas G, Beck, Lillie, Braas, Daniel, Cass, Ashley, Chan, Shawna, Christofk, Heather R, Delgado, Adrian, Friedman, Michael, Go, James, Graeber, Thomas G, Graham, Nicholas A, Hurtz, Christian, Larson, Steven M, Lomova, Anastasia, Mellinghoff, Ingo K, Minasyan, Aspram, Multani, Asha S, Müschen, Markus, Ng, Carina, Palaskas, Nicolaos, Port, Elisa, Qiao, Rong, Schultz, Nikolaus, Ten Hoeve, Johanna, Wu, Hong, Zhao, Sophie   +25 more
core   +3 more sources

Large-scale hypomethylated blocks associated with Epstein-Barr virus–induced B-cell immortalization

Genome Research, 2014
Altered DNA methylation occurs ubiquitously in human cancer from the earliest measurable stages. A cogent approach to understanding the mechanism and timing of altered DNA methylation is to analyze it in the context of carcinogenesis by a defined agent ...
Kasper D. Hansen, S. Sabunciyan, Ben Langmead, N. Nagy, Rebecca Curley, G. Klein, E. Klein, D. Salamon, A. Feinberg   +8 more
semanticscholar   +1 more source

Strategies for immortalization of primary hepatocytes

Journal of Hepatology, 2014
The liver has the unique capacity to regenerate in response to a damaging event. Liver regeneration is hereby largely driven by hepatocyte proliferation, which in turn relies on cell cycling. The hepatocyte cell cycle is a complex process that is tightly
Ramboer Eva, De Craene Bram, De Kock Joery, Vanhaecke Tamara, Berx Geert, Rogiers Vera, Vinken Mathieu   +6 more
semanticscholar   +1 more source

Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts

Chinese Medical Journal
. Background:. P16 inactivation is frequently accompanied by telomerase reverse transcriptase (TERT) amplification in human cancer genomes. P16 inactivation by DNA methylation often occurs automatically during immortalization of normal cells by TERT ...
Xuehong Zhang, Paiyun Li, Ying Gan, Shengyan Xiang, Liankun Gu, Jing Zhou, Xiaorui Zhou, Peihuang Wu, Baozhen Zhang, Dajun Deng, Jing Ni   +10 more
doaj   +1 more source

Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors [PDF]

, 2018
Background Reprogramming of cancers into normal-like tissues is an innovative strategy for cancer treatment. Recent reports demonstrate that defined factors can reprogram cancer cells into pluripotent stem cells. Glioblastoma multiforme (GBM) is the most
Hallahan, Dennis, He, Liming, Wu, Ling-Gang, Yang, Qin, You, Meng, Yuan, Jie, Zhang, Fan, Zhang, Zhen   +7 more
core   +2 more sources

Evolution and Immortality [PDF]

Monist, 1900
n ...
openaire   +2 more sources

Human Derived Immortalized Dermal Papilla Cells With a Constant Expression of Testosterone Receptor

Frontiers in Cell and Developmental Biology, 2020
Androgenetic alopecia (AGA) is the most common type of hair loss, and is mainly caused by the biological effects of testosterone on dermal papilla cells (DPCs). In vitro culturing of DPCs might be a useful tool for the screening of target molecule of AGA.
Tomokazu Fukuda, Tomokazu Fukuda, Kouhei Takahashi, Shin Takase, Ai Orimoto, Takahiro Eitsuka, Kiyotaka Nakagawa, Tohru Kiyono   +7 more
doaj   +1 more source

Immortalization of human adipose-derived stromal cells: production of cell lines with high growth rate, mesenchymal marker expression and capability to secrete high levels of angiogenic factors

Stem cell research & therapeutics, 2014
Human adipose-derived stromal cells (hASCs), due to their relative feasibility of isolation and ability to secrete large amounts of angiogenic factors, are being evaluated for regenerative medicine.
L. Balducci, A. Blasi, M. Saldarelli, A. Soleti, A. Pessina, A. Bonomi, V. Coccè, M. Dossena, V. Tosetti, V. Ceserani, S. Navone, M. Falchetti, E. Parati, G. Alessandri   +13 more
semanticscholar   +1 more source

KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway. [PDF]

, 2017
Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells ...
Chen, Miao, Deng, Wuguo, Fu, Xiaoyan, Gao, Fan, Huang, Wenlin, Kang, Lan, Li, Wenbin, Li, Yixin, Liu, Tianze, Qin, Ge, Shi, Dingbo, Shi, Fen, Song, Chen, Tang, Bing, Tang, Ranran, Wu, Xiaojun, Xiao, Binyi, Xiao, Xiangsheng, Zhang, Changlin   +18 more
core   +1 more source

Derivation and Characterization of Immortalized Human Muscle Satellite Cell Clones from Muscular Dystrophy Patients and Healthy Individuals

Cells, 2020
In Duchenne muscular dystrophy (DMD) patients, absence of dystrophin causes muscle wasting by impacting both the myofiber integrity and the properties of muscle stem cells (MuSCs).
Jimmy Massenet, Cyril Gitiaux, Mélanie Magnan, Sylvain Cuvellier, Arnaud Hubas, Patrick Nusbaum, F Jeffrey Dilworth, Isabelle Desguerre, Bénédicte Chazaud   +8 more
doaj   +1 more source