Results 41 to 50 of about 75,693 (242)

E6/E7 Functional Differences among Two Natural Human Papillomavirus 18 Variants in Human Keratinocytes

Viruses, 2021
It is suggested that HPV-18 variants from the A lineage have higher oncogenic potential compared to B variants. Some studies show uneven distribution of HPV-18 variants in cervical adenocarcinomas and squamous cell carcinomas.
Emily Montosa Nunes, Valéria Talpe-Nunes, João Simão Sobrinho, Silvaneide Ferreira, Vanesca de Souza Lino, Lara Termini, Gabriela Ávila Fernandes Silva, Enrique Boccardo, Luisa Lina Villa, Laura Sichero   +9 more
doaj   +1 more source

Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming [PDF]

, 2013
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes ...
A Calender, A Chen, A Chen, A Le Roux, A Mor, A Rada-Iglesias, A Saha, A Sjoblom, A Smith, Aaron Arvey, Aditi Kanhere, AJ Sinclair, B Akhtar-Zaidi, B Kempkes, B Tomkinson, B Tomkinson, B Zhao, B Zhao, B Zhao, B Zhao, Bettina Kempkes, C Kaiser, C Kintner, C Subramanian, C. David Wood, CD Gregory, CF Eisenbeis, D Marshall, D Portal, D Wang, DY Wu, DY Wu, E Anderton, E Johannsen, EM Fuentes-Panana, EO Long, ES Robertson, F Lu, F Nitsche, F Wang, F Wang, F Wang, G Chinnadurai, G Laux, GL Kelly, H Ben-Bassat, Helen M. Webb, I Tempera, J O'Nions, JC Knutson, JI Cohen, JI Cohen, JI Cohen, JM Boyd, JS Knight, K Paschos, K Paschos, KG Krauer, L Skalska, L Skalska, L Waltzer, L Waltzer, L Wang, LC Spender, LC Spender, M Bain, M Bulger, M Cordier, M Hickabottom, M Wade, M Woisetschlaeger, MA Epstein, Marie L. Harth-Hertle, MB Gerstein, Michael J. McClellan, Michelle J. West, MJ Maunders, MJ McClellan, MJ West, ML Hertle, MM Pomerantz, MP Creyghton, N Ahmadiyeh, N Naumova, ND Heintzman, Opeoluwa Ojeniyi, P Nurse, PA Nikitin, Paul M. Lieberman, R Touitou, RD Palermo, RE White, RE White, Richard D. Palermo, Richard G. Jenner, S Banerjee, S Harada, S Maier, S Maruo, S Maruo, S Maruo, S Paliwal, S Tuupanen, SA Radkov, SJ Bark-Jones, SN Schlick, SR Grossman, T Choudhuri, T Henkel, Tim J. Cooper, U Schaeper, U Zimber-Strobl, VS Chopra, W Lucchesi, X Tong, X Tong, X Tong, Y Zhang   +117 more
core   +3 more sources

Immortality [PDF]

Monist, 1891
n ...
openaire   +1 more source

Potential for Isolation of Immortalized Hepatocyte Cell Lines by Liver-Directed In Vivo Gene Delivery of Transposons in Mice

Stem Cells International, 2019
Isolation of hepatocytes and their culture in vitro represent important avenues to explore the function of such cells. However, these studies are often difficult to perform because of the inability of hepatocytes to proliferate in vitro.
Masahiro Sato, Issei Saitoh, Emi Inada, Shingo Nakamura, Satoshi Watanabe   +4 more
doaj   +1 more source

Mesenchymal Differentiation and Organ Distribution of Established Human Stromal Cell Lines in NOD/SCID Mice [PDF]

, 2001
Two human stromal cell lines were established previously from bone marrow-derived primary long-term cultures by immortalization using the SV40 large T antigen and cellular cloning. After irradiation, the fibroblast-like cell lines L87/4 and L88/5 support
Huss, Ralf, Meissner, Petra, Moosmann, Sabine, Sagebiel, Sabine, Thalmeier, Karin, Wiest, Irmgard   +5 more
core   +1 more source

ROCK inhibitor reduces Myc-induced apoptosis and mediates immortalization of human keratinocytes

OncoTarget, 2016
The Myc/Max/Mad network plays a critical role in cell proliferation, differentiation and apoptosis and c-Myc is overexpressed in many cancers, including HPV-positive cervical cancer cell lines.
Aleksandra Dakić, K. Divito, Shuang Fang, F. Suprynowicz, Anirudh Gaur, Xin Li, Nancy Palechor-Ceron, V. Simic, S. Choudhury, Songtao Yu, C. Simbulan-Rosenthal, D. Rosenthal, R. Schlegel, Xuefeng Liu   +13 more
semanticscholar   +1 more source

The Immortal Senescence [PDF]

, 2016
Activation of oncogenic signaling paradoxically results in the permanent withdrawal from cell cycle and induction of senescence (oncogene-induced senescence (OIS)). OIS is a fail-safe mechanism used by the cells to prevent uncontrolled tumor growth, and, as such, it is considered as the first barrier against cancer.
Anna, Bianchi-Smiraglia, Brittany C, Lipchick, Mikhail A, Nikiforov   +2 more
openaire   +2 more sources

Coevolution of neoplastic epithelial cells and multilineage stroma via polyploid giant cells during immortalization and transformation of mullerian epithelial cells

Genes & cancer, 2016
Stromal cells are generally considered to be derived primarily from the host's normal mesenchymal stromal cells or bone marrow. However, the origins of stromal cells have been quite controversial. To determine the role of polyploidy in tumor development,
Shiwu Zhang, I. Mercado-uribe, A. Sood, R. Bast, Jinsong Liu   +4 more
semanticscholar   +1 more source

Short-Chain Fatty Acids Regulate the Immune Responses via G Protein-Coupled Receptor 41 in Bovine Rumen Epithelial Cells

Frontiers in Immunology, 2019
The rumen immune system often suffers when challenging antigens from lysis of dead microbiota cells in the rumen. However, the rumen epithelium innate immune system can actively respond to the infection.
Kang Zhan, Xiaoxiao Gong, Yinyin Chen, Maocheng Jiang, Tianyu Yang, Guoqi Zhao   +5 more
doaj   +1 more source

Oral cancer secretome: Identification of cancer-associated proteins [PDF]

, 2014
This study aims to identify cancer-associated proteins in the secretome of oral cancer cell lines. We have successfully established four primary cell cultures of normal cells with a limited lifespan without human telomerase reverse transcriptase (hTERT ...
Chang, H. Y., Cheong, S. C., Hor, S. Y., Karsani, S. A., Lim, K. P., Rahman, M. A., Zain, R. B.   +6 more
core   +1 more source