Results 31 to 40 of about 75,693 (242)

Immortalization of mouse myogenic cells can occur without loss of p16^INK4a, p19^ARF, or p53 and is accelerated by inactivation of Bax

BMC Cell Biology, 2004
Background Upon serial passaging of mouse skeletal muscle cells, a small number of cells will spontaneously develop the ability to proliferate indefinitely while retaining the ability to differentiate into multinucleate myotubes.
Kravetz Amanda J, Kostek Christine A, Girgenrath Mahasweta, Malowitz Jonathan, Nowak Jonathan A, Dominov Janice A, Miller Jeffrey   +6 more
doaj   +1 more source

A prospect of cell immortalization combined with matrix microenvironmental optimization strategy for tissue engineering and regeneration

Cell & Bioscience, 2019
Cellular senescence is a major hurdle for primary cell-based tissue engineering and regenerative medicine. Telomere erosion, oxidative stress, the expression of oncogenes and the loss of tumor suppressor genes all may account for the cellular senescence ...
Yi-ming Wang, Song Chen, Zuoqin Yan, M. Pei   +3 more
semanticscholar   +1 more source

Ageing and immortality [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2000
The concept of the force of natural selection was developed to explain the evolution of ageing. After ageing, however, comes a period in which mortality rates plateau and some individual organisms could, in theory, live forever. This late–life immortality has no presently agreed upon explanation. Two main theories have been offered.
Rose, Michael R, Mueller, Laurence D
openaire   +4 more sources

Localization of the Major NF-κB-activating Site and the Sole TRAF3 Binding Site of LMP-1 Defines Two Distinct Signaling Motifs [PDF]

, 1997
The TRAF3 molecule interacts with the cytoplasmic carboxyl terminus (COOH terminus) of the Epstein-Barr virus-encoded oncogene LMP-1. NF-κB activation is a downstream signaling event of tumor necrosis factor receptor-associated factor (TRAF) molecules in
Baltimore, David, Brodeur, Scott R., Cheng, Genhong, Thorley-Lawson, David A.   +3 more
core   +1 more source

Fallen Immortals [PDF]

Cell, 2009
The memory of somatic cell gene expression is reset in the germline in a process that is accompanied by dramatic changes in chromatin modifications. In this issue, Katz et al. (2009) show that the histone demethylase Lsd1/Spr-5 may participate in this resetting process in the worm, thereby preventing a decline in germ cell epigenetic stability and ...
Swigut, Tomek, Wysocka, Joanna
openaire   +2 more sources

Primary skin fibroblasts as a model of Parkinson's disease [PDF]

, 2012
Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease.
A Grunewald, A Grunewald, A Petit, A Rakovic, A Sajadi, A Sprenger, AL Fridman, AL Fridman, AW Michell, B Stefano Di, Blas Morales-Gordo, C Mytilineou, C Piccoli, CA Costa da, CM Clements, DP Narendra, DT Woodley, E Fernandez-Espejo, EM Valente, F Pan-Montojo, F Soldner, FR Wiedemann, G Tesco, Georg Auburger, GP Connolly, H Braak, H Jiang, H Mortiboys, Heinz Reichmann, HH Hoepken, HH Hoepken, HM Huang, HM Huang, IF Khan, IH Park, J Hoenicka, J Waak, Jessica Drost, JM Harper, K Bayreuther, K Gorner, K Isobe, K Winkler-Stuck, Katrin Marcus, KH Narsinh, L Gasparini, L Grandoso, LS Tain, M Garcia-Arencibia, M Ikemura, M Jendrach, M Klinkenberg, M Sun, M Varma, M Wernig, Marina Jendrach, MB Graeber, MC Maj, Michael Klinkenberg, N Exner, N Hirashima, O Rothfuss, P Hoyo del, P Rieske, R Djaldetti, R Musanti, S Geisler, S Gispert, S Kaneko, S Mai, SM Hussein, Suzana Gispert, T Amo, T Gasser, T Shishido, Ulrich Brandt, Vania Broccoli, WG Tatton, Wolfram S. Kunz, WY Lee, Y Miki, Y Ren, Y Ren, YC Kim, Z Jingzhong   +84 more
core   +1 more source

Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system

Journal of Neurovirology, 2016
The major reservoirs for HIV in the CNS are in the microglia, perivascular macrophages, and to a lesser extent, astrocytes. To study the molecular events controlling HIV expression in the microglia, we developed a reliable and robust method to ...
Yoelvis Garcia-Mesa, T. Jay, M. Checkley, B. Luttge, C. Dobrowolski, S. Valadkhan, Gary E. Landreth, Jonathan Karn, David Alvarez-Carbonell   +8 more
semanticscholar   +1 more source

Fully Human Herpesvirus-Specific Neutralizing IgG Antibodies Generated by EBV Immortalization of Splenocytes-Derived from Immunized Humanized Mice

Cells, 2023
Antiviral neutralizing antibodies (nAbs) are commonly derived from B cells developed in immunized or infected animals and humans. Fully human antibodies are preferred for clinical use as they are potentially less immunogenic.
Sebastian J. Theobald, Elena Fiestas, Andreas Schneider, Benjamin Ostermann, Simon Danisch, Constantin von Kaisenberg, Jan Rybniker, Wolfgang Hammerschmidt, Reinhard Zeidler, Renata Stripecke   +9 more
doaj   +1 more source

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.

Genes & Development, 1998
Establishment of primary mouse embryo fibroblasts (MEFs) as continuously growing cell lines is normally accompanied by loss of the p53 or p19(ARF) tumor suppressors, which act in a common biochemical pathway.
F. Zindy, C. M. Eischen, D. H. Randle, T. Kamijo, J. Cleveland, C. Sherr, M. Roussel   +6 more
semanticscholar   +1 more source

Establishment and characterization of HBV-associated B lymphocytes with an immortalization potential.

PLoS ONE, 2019
Emerging evidences indicate that hepatitis B virus (HBV) infection is associated with non-Hodgkin lymphoma (NHL), but the mechanisms of HBV-induction lymphomagenesis remain unclear.
Xiaoying Qi, Xien Gui, Ke Zhuang
doaj   +1 more source