Results 121 to 130 of about 6,519,090 (301)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Extracorporeal immune therapy with immobilized agonistic anti-Fas antibodies leads to transient reduction of circulating neutrophil numbers and limits tissue damage after hemorrhagic shock/resuscitation in a porcine model [PDF]

, 2010
Background: Hemorrhagic shock/resuscitation is associated with aberrant neutrophil activation and organ failure. This experimental porcine study was done to evaluate the effects of Fas-directed extracorporeal immune therapy with a leukocyte inhibition ...
Sarah Sadek, Altrichter, Jens, José Bitu-Moreno, Windolf Joachim, Scholz Martin, Ott Annina, Sadek Sarah, Teresa Jeri, Adnana Paunel-Görgülü, Martin Sager, Baltes Jessica, Müller, Wolfram, Sager, Martin, Witte Ingo, Ingo Witte, Jens Altrichter, Martin Scholz, Sager Martin, Sadek, Sarah, Schek, Alberto, Bitu-Moreno José, Windolf, Joachim, Lögters, Tim Tobias, Witte, Ingo, Bitu-Moreno, José, Jeri, Teresa, Altrichter Jens, Paunel-Görgülü Adnana, Jeri Teresa, Joachim Windolf, Alberto Schek, Baltes, Jessica, Wolfram Müller, Annina Ott, Müller Wolfram, Schek Alberto, Scholz, Martin, Jessica Baltes, Ott, Annina, Tim T Lögters, Paunel-Görgülü, Adnana-Nicoleta, Lögters Tim T   +41 more
core   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Molecular immune signatures of T-cell infiltration in cancer [PDF]

, 2016
There is currently a strong interest in cancer research to profile the tumor- immune microenvironment to understand the complicated interplay of immune targeting and escape. With the recent developments of immune checkpoint inhibitors, which overcome the
Levy, Eric Daniel
core  

Immune-Related Genes and Immune Cell Infiltration Characterize the Maturation Status of Arteriovenous Fistulas: An Integrative Bioinformatics Study and Experimental Validation Based on Transcriptome Sequencing

Journal of Inflammation Research
Peng Lu,1,2,* Tun Wang,1,2,* Zicheng Wan,1,2 Mo Wang,1,2 Yang Zhou,1,2 Zhenyu He,1,2 Sheng Liao,1,2 Haiyang Liu,3 Chang Shu1,2,4 1Department of Vascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, People’s Republic ...
Lu P, Wang T, Wan Z, Wang M, Zhou Y, He Z, Liao S, Liu H, Shu C   +8 more
doaj  

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Tumor immune cell infiltration and TIMELESS expression in LUAD.

(A) Correlation between TIMELESS expression and immune cell infiltration in TCGA LUAD tumor tissues. (B) Heatmap of immune cell infiltration in TCGA LUAD tumor tissues stratified by TIMELESS expression level. *p value < 0.05; **p value < 0.01; ***p value
Suyan Tian (133000), Mingbo Tang (11580966), Shixiong Wei (9330749), Xinliang Gao (11580963), Shucheng Hua (776296), Jialin Li (382950), Wei Liu (20030)   +6 more
core   +1 more source

Oxidative damage and chemokine production dominate days before immune cell infiltration and EAE disease debut

, 2016
Data files on which the results presented in the manuscript 'Oxidative damage and chemokine production dominate days before immune cell infiltration and EAE disease debut' are based.
Henrik Hasseldam (2855891)
core   +1 more source