Results 101 to 110 of about 624,288 (309)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The prognostic value of tumor mutation burden (TMB) and its relationship with immune infiltration in breast cancer patients

European Journal of Medical Research, 2023
Objective Although the tumor mutation burden (TMB) was reported as a biomarker for immunotherapy of various cancers, whether it can effectively predict the survival prognosis in breast cancer patients remains unclear.
Shengjin Cui, Jingying Feng, Xi Tang, Shuang Lou, Weiquan Guo, Xiaowei Xiao, Shuping Li, Xue Chen, Yu Huan, Yiwen Zhou, Lijia Xiao   +10 more
doaj   +1 more source

Pathologic evaluation of tumor-associated macrophage density and vessel inflammation in invasive breast carcinomas [PDF]

, 2017
Tumor-associated macrophages (TAMs) are major constituents of the tumor microenvironment in solid tumors and have been implicated as mediators of tumor progression, invasion and metastasis.
Adhikari, Smita, Chervoneva, Inna, Hasan, Nafis, Leslie, Macall, Morita, Yoshihiro, Rui, Hallgeir, Tanaka, Takemi, Zhang, Roy   +7 more
core   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

TERT promoter methylation predicts overall survival, immune cell infiltration and response to immunotherapy in clear cell renal cell carcinoma

Clinical Epigenetics
Purpose Telomerase reverse transcriptase (TERT) is one of the most well-established oncogenes in tumor development and progression. It is widely known that TERT promoter hypermethylation is associated with its transcription activation.
Xinyu Guan, Jiahao Meng, Wenjun Yi, Kun Ye, Hongyu Gao, Yue Hong, Limeng Qu, Shirong Ding, Qian Long   +8 more
doaj   +1 more source

Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes. [PDF]

, 2019
BackgroundThe major histocompatibility complex class I (MHC-I) molecule is a protein complex that displays intracellular peptides to T cells, allowing the immune system to recognize and destroy infected or cancerous cells.
Carter, Hannah, Castro, Andrea, Ozturk, Kivilcim, Pyke, Rachel Marty, Xian, Su, Zanetti, Maurizio   +5 more
core   +1 more source

Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection [PDF]

, 2017
Salmonella Typhimurium causes a self-limiting gastroenteritis that may lead to systemic disease. Bacteria invade the small intestine, crossing the intestinal epithelium from where they are transported to the mesenteric lymph nodes (MLNs) within migrating
A Perez-Lopez, A Srinivasan, AG Peniche, AL John St, AM Race, AS Attia, B Dugas, B Flatley, B García, BD Corbin, C Otsubo, C O’Mahony, CS Macedo de, E-H Hong, F Hacini-Rachinel, FM Goñi, G Robichaud, G Walzl, GM Fraser, IB Wenderska, J Bene, J Hess, JD Turner, JM Ertelt, JM Rutkowsky, K Schwamborn, KA Oswald-Richter, KHG Mills, KKW To, KL O’Hagan, KSH Beckham, M Barthel, M Gaya, MA Jepson, MC Mutomba, MI Hood, MP Fink, N Desbenoit, O Klein, P Mastroeni, PL Chen, R Daniels, R Rosales-Reyes, RJA Goodwin, S Gravius, S Létourneau, S Pie, S Voedisch, T Goto, T Liu, T Okada, TG Glaros, UT Nguyen, VD Peltekova, X Liu, Y Li, Y Souwer, YR Carrasco   +57 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Integrated analysis of single-cell and bulk RNA-seq reveals MAGEA3/6-associated immune subtypes and key immune genes in gastric cancer.

PLoS ONE
The immune microenvironment is critical in gastric cancer (GC), yet epithelial-specific genes linked to immune infiltration remain poorly defined.
Linen Li, Hao Chen, Feng Zhou, Yanqing Shi   +3 more
doaj   +1 more source

CEACAM6 Expression is Associated with Immune Infiltration and Poor Prognosis in Esophageal Squamous Cell Carcinoma

Zhongliu Fangzhi Yanjiu
ObjectiveTo investigate the expression of carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) in esophageal squamous cell carcinoma (ESCC) and analyze its correlation with immune cell infiltration and patient prognosis.
Jiahui LI, Enwei XU, Wei CUI, Yuanyuan ZHAO, Keqing KANG, Peng BU, Guohai ZHAO, Yang ZHOU   +7 more
doaj   +1 more source