Results 101 to 110 of about 6,100,412 (305)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Molecular immune signatures of T-cell infiltration in cancer [PDF]

, 2016
There is currently a strong interest in cancer research to profile the tumor- immune microenvironment to understand the complicated interplay of immune targeting and escape. With the recent developments of immune checkpoint inhibitors, which overcome the
Levy, Eric Daniel
core  

WITHDRAWN: Characterization of Patterns of Immune Cell Infiltration in NSCLC

Journal of Thoracic Oncology, 2020
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
Max, Backman, Linnéa, La Fleur, Pinja, Kurppa, Dijana, Djureinovic, Hedvig, Elfving, Hans, Brunnström, Johanna S M, Mattsson, Victor, Pontén, Mohamed, Eltahir, Sara, Mangsbo, Johan, Isaksson, Karin, Jirström, Klas, Kärre, Ennio, Carbone, Karin, Leandersson, Artur, Mezheyeuski, Fredrik, Pontén, Cecilia, Lindskog, Johan, Botling, Patrick, Micke   +19 more
openaire   +2 more sources

T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution

Journal of Experimental & Clinical Cancer Research
Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain immune cells can impair this response and help tumor immune escape. Therefore, exploring the factors that influence
Wenhui Yang, Shimao Liu, Mengyun Mao, Yandong Gong, Xiaohui Li, Tianyu Lei, Chao Liu, Shikai Wu, Qinyong Hu   +8 more
doaj   +1 more source

CEACAM6 Expression is Associated with Immune Infiltration and Poor Prognosis in Esophageal Squamous Cell Carcinoma

Zhongliu Fangzhi Yanjiu
ObjectiveTo investigate the expression of carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) in esophageal squamous cell carcinoma (ESCC) and analyze its correlation with immune cell infiltration and patient prognosis.
Jiahui LI, Enwei XU, Wei CUI, Yuanyuan ZHAO, Keqing KANG, Peng BU, Guohai ZHAO, Yang ZHOU   +7 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

mosmoon/extracellular-acidification-impairs-T-cell-infiltration-and-antitumor-activity: extracellular-acidification-impairs-T-cell-infiltration-and-antitumor-activity

<p>extracellular-acidification-impairs-T-cell-infiltration-and-antitumor-activity</p ...
mosmoon
core   +1 more source

Integrated Analysis of Immune Infiltration and Hub Pyroptosis-Related Genes for Multiple Sclerosis

, 2023
Shaoru Zhang,* Yue Ma,* Xiaoqin Luo, Hongmei Xiao, Ruiqi Cheng, Anan Jiang, Xinyue Qin Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China*These authors contributed ...
Cheng R, Xiao H, Jiang A, Qin X, Ma Y, Luo X, Zhang S   +6 more
core  

CCR2+ migratory macrophages with M1 status are the early-responders in the cornea of HSV-1 infected mice.

PLoS ONE, 2019
Complex interactions between HSV-1 and infiltrating immune cells play important roles in establishing localized, acute virus replication as well as chronic latent infection. The extent and duration of initial virus replication are the key determinants of
Dhong Hyun Lee, Ujjaldeep Jaggi, Homayon Ghiasi   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source