Results 91 to 100 of about 6,100,412 (305)

Immune cell infiltration profiles.

, 2023
a) correlation between T-cell CD4+ Th2 (Th2) cells infiltration rate and HJURP gene expression, b) correlation between MDSC infiltration rate and HJURP gene expression, c) correlation between HSC infiltration rate and HJURP gene expression.
Kara E. McCloskey (3374330), Shiwani Limbu (17373563)   +1 more
core   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Immune cell infiltration analysis between OA and OB.

, 2023
Immune cell infiltration analysis between OA and OB.
Weihua Li (144468), Qiu Li (2127361), Xijie Tang (17692306)   +2 more
core   +1 more source

Exploring LTB-mediated T cell differentiation as a prognostic marker in triple-negative breast cancer

Breast Cancer Research
Immune infiltration in triple-negative breast cancer (TNBC) is associated with patient prognosis. However, the precise phenotypic classifications of immune infiltration in TNBC remain unclear, and the key regulatory mechanisms underlying this process ...
Xuekai Wang, Yingxiao Ni, Yang Shi, Xiaofeng Yu, Chenchen Wu, Zhuo Xiang, Wei Lv, Qiang Wang   +7 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Associations between CDCA2 expression and immune cell infiltration in LGG.

, 2023
(A) The correlation between CDCA2 and immune cell infiltration; (B, C, D) The correlation between CDCA2 and stromalscore, immune score and estimate score; (E) The differential expression of immune cells in the high and low CDCA2 expression groups in LGG;
Wenle Li (1234731), Chengjie Xu (9231483), Zhenzhe Li (7322933), Wensheng Li (309393), Dong Lv (3355730), Huanqiang Liu (17020744), Jieqin Yao (17020738), Boxian Chen (17020741)   +7 more
core   +1 more source

TERT promoter methylation predicts overall survival, immune cell infiltration and response to immunotherapy in clear cell renal cell carcinoma

Clinical Epigenetics
Purpose Telomerase reverse transcriptase (TERT) is one of the most well-established oncogenes in tumor development and progression. It is widely known that TERT promoter hypermethylation is associated with its transcription activation.
Xinyu Guan, Jiahao Meng, Wenjun Yi, Kun Ye, Hongyu Gao, Yue Hong, Limeng Qu, Shirong Ding, Qian Long   +8 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Integrated analysis of single-cell and bulk RNA-seq reveals MAGEA3/6-associated immune subtypes and key immune genes in gastric cancer.

PLoS ONE
The immune microenvironment is critical in gastric cancer (GC), yet epithelial-specific genes linked to immune infiltration remain poorly defined.
Linen Li, Hao Chen, Feng Zhou, Yanqing Shi   +3 more
doaj   +1 more source