Results 91 to 100 of about 624,288 (309)

Leveraging machine learning models to evaluate immune infiltration in the ovarian cancer microenvironment: a single-cell analysis approach

Discover Oncology
Background The prognosis of ovarian cancer is closely related to the degree of immune cell infiltration within the tumor microenvironment. However, current methods for assessing immune infiltration have certain subjective limitations. This study aimed to
Jie Liu, Baoguo Xia, Bingxin Li, Hui Liang   +3 more
doaj   +1 more source

HPV infection related immune infiltration gene associated therapeutic strategy and clinical outcome in HNSCC

BMC Cancer, 2020
Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most common tumor in human. Research has shown that HPV status HNSCC is a unique prognosis factor, which may due to its immune infiltration landscape.
Hao Zeng, Xindi Song, Jianrui Ji, Linyan Chen, Qimeng Liao, Xuelei Ma   +5 more
doaj   +1 more source

Cuproptosis-related modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of kidney renal clear cell carcinoma

Frontiers in Immunology, 2022
BackgroundDue to the different infiltration abundance of immune cells in tumor, the efficacy of immunotherapy varies widely among individuals. Recently, growing evidence suggested that cuproptosis has impact on cancer immunity profoundly.
Zhiyong Cai, You'e He, Zhengzheng Yu, Jiao Hu, Zicheng Xiao, Xiongbing Zu, Zhenghao Li, Huihuang Li   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Metformin-induced activation of Ca2+ signaling prevents immune infiltration/pathology in Sjogren’s syndrome-prone mouse models

Journal of Translational Autoimmunity, 2023
Immune cell infiltration and glandular dysfunction are the hallmarks of autoimmune diseases such as primary Sjogren’s syndrome (pSS), however, the mechanism(s) is unknown. Our data show that metformin-treatment induces Ca2+ signaling that restores saliva
Viviane Nascimento Da Conceicao, Yuyang Sun, Xiufang Chai, Julian L. Ambrus, Bibhuti B. Mishra, Brij B. Singh   +5 more
doaj   +1 more source

Immune Cell Infiltrates in Atypical Teratoid/Rhabdoid Tumors [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2012
Objective:Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant tumor of the central nervous system. Its pathogenesis remains unknown. Like glioblastomas, AT/RTs contain brain cancer stem cells (CSCs) that suppress the immunity of patients and are resistant to conventional chemotherapy and radiation therapy. Considerable infiltration of immune
Jian-Qiang, Lu, Beverly A, Wilson, V Wee, Yong, Jeffrey, Pugh, Vivek, Mehta   +4 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Carbonic anhydrases CA1 and CA4 function in atmospheric CO2-modulated disease resistance [PDF]

, 2020
Main conclusion Carbonic anhydrases CA1 and CA4 attenuate plant immunity and can contribute to altered disease resistance levels in response to changing atmospheric CO2 conditions.
Pieterse, Corné M. J., Van Der Does, Dieuwertje, Van Dijken, Anja J. H., Van Wees, Saskia C. M., Vroegop-vos, Irene A., Zhou, Yeling, Zipfel, Cyril   +6 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Kinetics of Immune Cell Infiltration in Vaccinia Virus Keratitis [PDF]

Investigative Opthalmology & Visual Science, 2010
Vaccinia virus keratitis leading to blindness is a severe complication of smallpox vaccination. The clinical manifestations of vaccinia virus keratitis are similar to those of herpes simplex virus keratitis, a well-studied immunopathologic disease. Vaccinia virus keratitis is likely to involve an immunopathologic component, but little is known about ...
Sharon, Altmann, Megan, Toomey, Brittany, Nesbit, Kim, McIntyre, Jill, Covert, Richard Redd, Dubielzig, Gary, Leatherberry, Elizabeth, Adkins, Christopher J, Murphy, Curtis R, Brandt   +9 more
openaire   +2 more sources