Results 71 to 80 of about 1,693,225 (311)

cGAS-STING pathway expression correlates with genomic instability and immune cell infiltration in breast cancer

npj Breast Cancer
Genomic instability, as caused by oncogene-induced replication stress, can lead to the activation of inflammatory signaling, involving the cGAS-STING and JAK-STAT pathways.
Mengting Chen, Shibo Yu, T. van der Sluis, M. Zwager, C. Schröder, B. van der Vegt, M. V. van Vugt   +6 more
semanticscholar   +1 more source

Identification of Diagnostic Signatures and Immune Cell Infiltration Characteristics in Rheumatoid Arthritis by Integrating Bioinformatic Analysis and Machine-Learning Strategies

Frontiers in Immunology, 2021
Background Rheumatoid arthritis (RA) refers to an autoimmune rheumatic disease that imposes a huge burden on patients and society. Early RA diagnosis is critical to preventing disease progression and selecting optimal therapeutic strategies more ...
Rongguo Yu, Jiayu Zhang, Youguang Zhuo, Xu Hong, Jie-Tong Ye, Susu Tang, Yiyuan Zhang   +6 more
semanticscholar   +1 more source

The immune phenotypes and different immune escape mechanisms in colorectal cancer

Frontiers in Immunology, 2022
The tumor microenvironment (TME) plays a crucial role in tumor progression and metastasis. However, the immune phenotypes of colorectal cancer (CRC) and the underlying immune escape mechanism have not been studied sufficiently.
Yihao Mao, Yuqiu Xu, Jiang Chang, Wenju Chang, Wenju Chang, Yang Lv, Peng Zheng, Zhiyuan Zhang, Zhiqiang Li, Qi Lin, Qi Lin, Wentao Tang, Wentao Tang, Dexiang Zhu, Dexiang Zhu, Meiling Ji, Meiling Ji, Guodong He, Guodong He, Qingyang Feng, Qingyang Feng, Jianmin Xu, Jianmin Xu   +22 more
doaj   +1 more source

Chemokine ligand 14 correlates with immune cell infiltration in the gastric cancer microenvironment in predicting unfavorable prognosis

Frontiers in Pharmacology
Objective Gastric cancer (GC) is the world’s third-leading cause of cancer-related mortality; the prognosis for GC patients remains poor in terms of a lack of reliable biomarkers for early diagnosis and immune therapy response prediction. Here, we aim to
Bing Lu, Jiawen Shi, Tong Cheng, Cong Wang, Manyu Xu, Pingping Sun, Xiaojing Zhang, Lei Yang, Peng Li, Han Wu, Xiaoling Kuai   +10 more
semanticscholar   +1 more source

Tumor Mutation Burden, Immune Cell Infiltration, and Construction of Immune-Related Genes Prognostic Model in Head and Neck Cancer

International Journal of Medical Sciences, 2021
Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide, and the prognosis of HNSCC remains bleak. Numerous studies revealed that the tumor mutation burden (TMB) could predict the survival outcomes of a ...
Ai-min Jiang, Mengdi Ren, Na Liu, Huan Gao, Jingjing Wang, Xiaoqiang Zheng, Xiao Fu, Xuan Liang, Zhiping Ruan, T. Tian, Yu Yao   +10 more
semanticscholar   +1 more source

Identification and Validation of Immune-Related Genes and Immune Cell Infiltration in Preeclampsia

, 2021
Abstract Background Preeclampsia (PE) is a complex multisystem disease and its etiology remains unclear. The aim of this study was to identify potential immune-related diagnostic genes for PE, analyze the role of immune cell infiltration in PE, and explore the mechanism underlying PE-induced disruption of immune tolerance at the maternal-fetal
Rongxin Chen, Qing Han, Huale Zhang, Jianying Yan   +3 more
openaire   +1 more source

The Prognostic Landscape of Tumor-Infiltrating Immune Cells and Immune Checkpoints in Glioblastoma [PDF]

Technology in Cancer Research & Treatment, 2019
Tumor-infiltrating immune cells are part of a complex microenvironment and associated with improved clinical outcomes in a broad range of tumor types. However, a detailed map for the prognostic landscape of tumor-infiltrating immune cells and immune checkpoint modulators in glioblastoma is still lacking.
Shiman Wu, Wenli Yang, Hua Zhang, Yan Ren, Ziwei Fang, Chengjie Yuan, Zhenwei Yao   +6 more
openaire   +2 more sources

Characterization of the Immune Microenvironmental Landscape of Lung Squamous Cell Carcinoma with Immune Cell Infiltration

Disease Markers, 2022
Background. Increasing evidence supports that immune cell infiltration (ICI) patterns play a key role in the tumor progression of lung squamous cell carcinoma (LUSC). However, to date, the immune infiltration picture of LUSC has not been elucidated. Method. TCGA was used to download multiomics data from LUSC samples.
Chunji Chen, Dongfang Tang, Chang Gu, Bin Wang, Yuanshan Yao, Rui Wang, Huibiao Zhang, Wen Gao   +7 more
openaire   +2 more sources

Characterizing the Tumor Microenvironment and Its Prognostic Impact in Breast Cancer

Cells
The tumor microenvironment (TME) is crucial in cancer development and therapeutic response. Immunotherapy is increasingly recognized as a critical component of cancer treatment.
Wenjuan Zhang, Alex Lee, Amit K. Tiwari, Mary Qu Yang   +3 more
doaj   +1 more source

NAT10-mediated upregulation of GAS5 facilitates immune cell infiltration in non-small cell lung cancer via the MYBBP1A-p53/IRF1/type I interferon signaling axis

Cell Death Discovery
Interactions of tumor cells with immune cells in the tumor microenvironment play an important role during malignancy progression. We previously identified that GAS5 inhibited tumor development by suppressing proliferation of tumor cells in non-small cell
Zimu Wang, Jing Luo, Hairong Huang, Li Wang, Tangfeng Lv, Zhaofeng Wang, Chuling Li, Yimin Wang, Jiaxin Liu, Qinpei Cheng, Xueying Zuo, Liwen Hu, M. Ye, Hongbing Liu, Yong Song   +14 more
semanticscholar   +1 more source