Results 51 to 60 of about 624,288 (309)

Cuproptosis regulator-mediated patterns associated with immune infiltration features and construction of cuproptosis-related signatures to guide immunotherapy

Frontiers in Immunology, 2022
BackgroundLiver hepatocellular carcinoma (HCC) is a prevalent cancer that lacks a sufficiently efficient approach to guide immunotherapy. Additionally, cuproptosis is a recently identified regulated cell death program that is triggered by copper ...
Gongjun Wang, Gongjun Wang, Ruoxi Xiao, Shufen Zhao, Libin Sun, Jing Guo, Wenqian Li, Yuqi Zhang, Xiaoqian Bian, Wensheng Qiu, Shasha Wang   +10 more
doaj   +1 more source

Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity [PDF]

The Journal of Immunology, 2018
Abstract Limited representation of intratumoral immune cells is a major barrier to tumor control. However, simply enhancing immune responses in tumor-draining lymph nodes or through adoptive transfer may not overcome the limited ability of tumor vasculature to support effector infiltration. An alternative is to promote a sustained immune
Victor H Engelhard, Anthony B Rodriguez, Ileana S Mauldin, Amber N Woods, J David Peske, Craig L Slingluff   +5 more
openaire   +2 more sources

The soldiers needed to be awakened: Tumor-infiltrating immune cells

Frontiers in Genetics, 2022
In the tumor microenvironment, tumor-infiltrating immune cells (TIICs) are a key component. Different types of TIICs play distinct roles. CD8+ T cells and natural killer (NK) cells could secrete soluble factors to hinder tumor cell growth, whereas regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) release inhibitory factors to ...
Wang Yaping, Wang Zhe, Chu Zhuling, Li Ruolei, Fan Pengyu, Guo Lili, Ji Cheng, Zhang Bo, Liu Liuyin, Hou Guangdong, Wang Yaoling, Hou Niuniu, Hou Niuniu, Ling Rui   +13 more
openaire   +3 more sources

Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse

OncoImmunology, 2021
A substantial fraction of patients with stage I–III colorectal adenocarcinoma (CRC) experience disease relapse after surgery with curative intent. However, biomarkers for predicting the likelihood of CRC relapse have not been fully explored.
Yasmin Kamal, Dennis Dwan, Hannah J. Hoehn, Rebeca Sanz-Pamplona, M. Henar Alonso, Victor Moreno, Chao Cheng, Michael J. Schell, Youngchul Kim, Seth I. Felder, Hedy S. Rennert, Marilena Melas, Charalampos Lazaris, Joseph D. Bonner, Erin M. Siegel, David Shibata, Gad Rennert, Stephen B. Gruber, H. Robert Frost, Christopher I. Amos, Stephanie L. Schmit   +20 more
doaj   +1 more source

Computational immune profiling in lung adenocarcinoma reveals reproducible prognostic associations with implications for immunotherapy

OncoImmunology, 2018
Non-small cell lung cancer is one of the leading causes of cancer-related death in the world. Lung adenocarcinoma, the most common type of non-small cell lung cancer, has been well characterized as having a dense lymphocytic infiltrate, suggesting that ...
Frederick S. Varn, Laura J. Tafe, Christopher I. Amos, Chao Cheng   +3 more
doaj   +1 more source

The immune phenotypes and different immune escape mechanisms in colorectal cancer

Frontiers in Immunology, 2022
The tumor microenvironment (TME) plays a crucial role in tumor progression and metastasis. However, the immune phenotypes of colorectal cancer (CRC) and the underlying immune escape mechanism have not been studied sufficiently.
Yihao Mao, Yuqiu Xu, Jiang Chang, Wenju Chang, Wenju Chang, Yang Lv, Peng Zheng, Zhiyuan Zhang, Zhiqiang Li, Qi Lin, Qi Lin, Wentao Tang, Wentao Tang, Dexiang Zhu, Dexiang Zhu, Meiling Ji, Meiling Ji, Guodong He, Guodong He, Qingyang Feng, Qingyang Feng, Jianmin Xu, Jianmin Xu   +22 more
doaj   +1 more source

Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencing. [PDF]

, 2019
Neuroinflammation commonly accompanies neurodegeneration, but the specific roles of resident and infiltrating immune cells during degeneration remains controversial.
Burns, Marie E, Karlen, Sarah J, Miller, Eric B, Ronning, Kaitryn E   +3 more
core   +2 more sources

Tumor infiltrating immune cells in gliomas and meningiomas

Brain, Behavior, and Immunity, 2016
Tumor-infiltrating immune cells are part of a complex microenvironment that promotes and/or regulates tumor development and growth. Depending on the type of cells and their functional interactions, immune cells may play a key role in suppressing the tumor or in providing support for tumor growth, with relevant effects on patient behavior.
Domingues, Patricia H., González-Tablas, María, Otero, Álvaro, Pascual-Argente, Daniel, Miranda, David, Ruiz-Martin, Laura, Sousa, Pablo, Ciudad, Juana, Gonçalves, Jesús, Lopes, Maria Celeste, Orfao, Alberto, Tabernero, María D.   +11 more
openaire   +3 more sources

The Prognostic Landscape of Tumor-Infiltrating Immune Cells and Immune Checkpoints in Glioblastoma [PDF]

Technology in Cancer Research & Treatment, 2019
Tumor-infiltrating immune cells are part of a complex microenvironment and associated with improved clinical outcomes in a broad range of tumor types. However, a detailed map for the prognostic landscape of tumor-infiltrating immune cells and immune checkpoint modulators in glioblastoma is still lacking.
Shiman Wu, Wenli Yang, Hua Zhang, Yan Ren, Ziwei Fang, Chengjie Yuan, Zhenwei Yao   +6 more
openaire   +2 more sources

Characterizing the Tumor Microenvironment and Its Prognostic Impact in Breast Cancer

Cells
The tumor microenvironment (TME) is crucial in cancer development and therapeutic response. Immunotherapy is increasingly recognized as a critical component of cancer treatment.
Wenjuan Zhang, Alex Lee, Amit K. Tiwari, Mary Qu Yang   +3 more
doaj   +1 more source