Results 51 to 60 of about 1,693,225 (311)

Tumor cell-intrinsic factors underlie heterogeneity of immune cell infiltration and response to immunotherapy

Immunity, 2018
Summary The biological and functional heterogeneity between tumors—both across and within cancer types—poses a challenge for immunotherapy. To understand the factors underlying tumor immune heterogeneity and immunotherapy sensitivity, we established a ...
Jinyang Li, Katelyn T. Byrne, Fangxue Yan, Taiji Yamazoe, Zeyu Chen, T. Baslan, Lee P. Richman, Jeffrey H. Lin, Yu H. Sun, A. Rech, D. Balli, Ceire A Hay, Yogev Sela, Allyson J Merrell, Shannon M. Liudahl, N. Gordon, Robert J. Norgard, Salina Yuan, Sixiang Yu, Timothy Chao, Shuai Ye, Karin T. S. Eisinger-Mathason, R. Faryabi, J. Tobias, S. Lowe, L. Coussens, J. Wherry, R. Vonderheide, B. Stanger   +28 more
semanticscholar   +1 more source

Quercetin Attenuates Trauma-Induced Heterotopic Ossification by Tuning Immune Cell Infiltration and Related Inflammatory Insult

Frontiers in Immunology, 2021
Heterotopic ossification (HO) is one of the most intractable disorders following musculoskeletal injury and is characterized by the ectopic presence of bone tissue in the soft tissue leading to severe loss of function in the extremities.
Juehong Li, Ziyang Sun, Gang Luo, Shuo Wang, Haomin Cui, Zhixiao Yao, Hao Xiong, Yunwei He, Yun Qian, Cunyi Fan   +9 more
semanticscholar   +1 more source

Immune signature of tumor infiltrating immune cells in renal cancer [PDF]

OncoImmunology, 2015
Tumor-associated immune cells have been discussed as an essential factor for the prediction of the outcome of tumor patients. Lymphocyte-specific genes are associated with a favorable prognosis in colorectal cancer but with poor survival in renal cell carcinoma (RCC).
Katharina, Geissler, Paolo, Fornara, Christine, Lautenschläger, Hans-Jürgen, Holzhausen, Barbara, Seliger, Dagmar, Riemann   +5 more
openaire   +2 more sources

Bioinformatical analysis of the key differentially expressed genes and associations with immune cell infiltration in development of endometriosis

BMC Genomic Data, 2022
This study explored the key genes related to immune cell infiltration in endometriosis. The Gene Expression Omnibus (GEO) datasets (GSE7305, GSE7307, and GSE11691), containing a total of 37 endometriosis and 42 normal tissues, were retrieved and analyzed
Shengnan Chen, Xiaoshan Chai, Xianqing Wu   +2 more
semanticscholar   +1 more source

The Heterogeneity of Immune Cell Infiltration Landscape and Its Immunotherapeutic Implications in Hepatocellular Carcinoma

Frontiers in Immunology, 2022
Immunotherapy, closely associated with immune infiltration and tumor mutation burden (TMB), is emerging as a promising strategy for treating tumors, but its low response rate in hepatocellular carcinoma (HCC) remains a major challenge. Herein, we applied
Yuanyuan Guo, Jing Yang, Kaidi Ren, Xueke Tian, Hua Gao, Xin Tian, Xiaojian Zhang, Q. Kan   +7 more
semanticscholar   +1 more source

PD-L1 expression, tumor mutational burden, and immune cell infiltration in non-small cell lung cancer patients with epithelial growth factor receptor mutations

Frontiers in Oncology, 2022
Background Immunotherapy using programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors seems less effective in non-small cell lung cancer (NSCLC) patients with epithelial growth factor receptor (EGFR) mutations. Varied responses
Tiantian Ma, Jin Jiao, R. Huo, Xiaofang Li, Guotao Fang, Qi Zhao, Weiwei Liu, Xiaoyong Han, Chenglin Xi, Yanan Wang, Y. Shang   +10 more
semanticscholar   +1 more source

THBS2 is Closely Related to the Poor Prognosis and Immune Cell Infiltration of Gastric Cancer

Frontiers in Genetics, 2022
Background: The potential functions of Thrombospondin 2 (THBS2) in the progression and immune infiltration of gastric cancer (GC) remain unclear. The purpose of this study was to clarify the role of THBS2 in GC prognosis and the relationship between ...
Shiyu Zhang, Han Yang, Xuelian Xiang, Li Liu, Huali Huang, G. Tang   +5 more
semanticscholar   +1 more source

Cancer Cell–Autonomous Parainflammation Mimics Immune Cell Infiltration [PDF]

Cancer Research, 2017
Abstract Parainflammation is a unique variant of inflammation, characterized by epithelial-autonomous activation of inflammatory response. Parainflammation has been shown to strongly promote mouse gut tumorigenesis upon p53 loss. In a recent study, we explored the prevalence of parainflammation in human cancer and determined its ...
Lasry, Audrey, Aran, Dvir, Butte, Atul J, Ben-Neriah, Yinon   +3 more
openaire   +4 more sources

Identification of testicular cancer immune infiltrates and novel immune cell subtypes

FEBS Open Bio, 2023
Testicular germ cell tumors (TGCT) are the most common type of testicular cancer, comprising 90–95% of cases and representing the most prevalent solid malignancy in young adult men. Immune infiltrates play important regulatory roles in tumors, but their role in TGCT remains unclear.
Zhiguo Zhu, Xujun Xuan, Xinkun Wang, Miaomiao Wang, Chunyang Meng, Zhonghai Li   +5 more
openaire   +3 more sources

Identification of GGT5 as a Novel Prognostic Biomarker for Gastric Cancer and its Correlation With Immune Cell Infiltration

Frontiers in Genetics, 2022
Gastric cancer (GC) is a common malignant tumor of the digestive system. Recent studies revealed that high gamma-glutamyl-transferase 5 (GGT5) expression was associated with a poor prognosis of gastric cancer patients.
Yuli Wang, Yuan Fang, Fanchen Zhao, Jiefei Gu, Xiang Lv, Rongzhong Xu, Bo Zhang, Zhihong Fang, Yan Li   +8 more
semanticscholar   +1 more source