Results 41 to 50 of about 6,100,412 (305)

Engineering the tumor microenvironment of colorectal cancer [PDF]

, 2014
The tumor microenvironment contributes significantly to the clinical prognosis, especially in CRC. Infiltration by cells from the adaptive immune system (e.g. CD8) has been linked to a better survival independently of TNM-stage.
Hirt, Christian Kurt
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Identification of testicular cancer immune infiltrates and novel immune cell subtypes

FEBS Open Bio, 2023
Testicular germ cell tumors (TGCT) are the most common type of testicular cancer, comprising 90–95% of cases and representing the most prevalent solid malignancy in young adult men. Immune infiltrates play important regulatory roles in tumors, but their role in TGCT remains unclear.
Zhiguo Zhu, Xujun Xuan, Xinkun Wang, Miaomiao Wang, Chunyang Meng, Zhonghai Li   +5 more
openaire   +3 more sources

Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity [PDF]

The Journal of Immunology, 2018
Abstract Limited representation of intratumoral immune cells is a major barrier to tumor control. However, simply enhancing immune responses in tumor-draining lymph nodes or through adoptive transfer may not overcome the limited ability of tumor vasculature to support effector infiltration. An alternative is to promote a sustained immune
Victor H Engelhard, Anthony B Rodriguez, Ileana S Mauldin, Amber N Woods, J David Peske, Craig L Slingluff   +5 more
openaire   +2 more sources

RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma

Cell Death Discovery, 2023
The failure of melanoma immunotherapy can be mediated by immunosuppression in the tumor microenvironment (TME), and insufficient activation of effector T cells against the tumor.
Yanan Guo, Rong Shen, Keren Yang, Yutong Wang, Haoyun Song, Xiangwen Liu, Xin Cheng, Rile Wu, Yanfeng Song, Degui Wang   +9 more
doaj   +1 more source

T-Cell Infiltration and Immune Checkpoint Expression Increase in Oral Cavity Premalignant and Malignant Disorders

, 2022
The immune cell niche associated with oral dysplastic lesion progression to carcinoma is poorly understood. We identified T regulatory cells (Treg), CD8(+) effector T cells (Teff) and immune checkpoint molecules across oral dysplastic stages of oral ...
Tu, Andrew A., S. Lynn Sigurdson, Kirkwood, Keith L., Hicks, Wesley L., Wesley L. Hicks, Keith L. Kirkwood, Aboelkheir, Usama, Kuriakose, Moni A., Andrew A. Tu, Moni A. Kuriakose, Usama Aboelkheir, Merzianu, Mihai, Surendran, Subin, Subin Surendran, Magner, William J., William J. Magner, Amritha Suresh, Suresh, Amritha, Sigurdson, S. Lynn, Mihai Merzianu   +19 more
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Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse

OncoImmunology, 2021
A substantial fraction of patients with stage I–III colorectal adenocarcinoma (CRC) experience disease relapse after surgery with curative intent. However, biomarkers for predicting the likelihood of CRC relapse have not been fully explored.
Yasmin Kamal, Dennis Dwan, Hannah J. Hoehn, Rebeca Sanz-Pamplona, M. Henar Alonso, Victor Moreno, Chao Cheng, Michael J. Schell, Youngchul Kim, Seth I. Felder, Hedy S. Rennert, Marilena Melas, Charalampos Lazaris, Joseph D. Bonner, Erin M. Siegel, David Shibata, Gad Rennert, Stephen B. Gruber, H. Robert Frost, Christopher I. Amos, Stephanie L. Schmit   +20 more
doaj   +1 more source

Cuproptosis regulator-mediated patterns associated with immune infiltration features and construction of cuproptosis-related signatures to guide immunotherapy

Frontiers in Immunology, 2022
BackgroundLiver hepatocellular carcinoma (HCC) is a prevalent cancer that lacks a sufficiently efficient approach to guide immunotherapy. Additionally, cuproptosis is a recently identified regulated cell death program that is triggered by copper ...
Gongjun Wang, Gongjun Wang, Ruoxi Xiao, Shufen Zhao, Libin Sun, Jing Guo, Wenqian Li, Yuqi Zhang, Xiaoqian Bian, Wensheng Qiu, Shasha Wang   +10 more
doaj   +1 more source

The Prognostic Landscape of Tumor-Infiltrating Immune Cells and Immune Checkpoints in Glioblastoma [PDF]

Technology in Cancer Research & Treatment, 2019
Tumor-infiltrating immune cells are part of a complex microenvironment and associated with improved clinical outcomes in a broad range of tumor types. However, a detailed map for the prognostic landscape of tumor-infiltrating immune cells and immune checkpoint modulators in glioblastoma is still lacking.
Shiman Wu, Wenli Yang, Hua Zhang, Yan Ren, Ziwei Fang, Chengjie Yuan, Zhenwei Yao   +6 more
openaire   +2 more sources

Computational immune profiling in lung adenocarcinoma reveals reproducible prognostic associations with implications for immunotherapy

OncoImmunology, 2018
Non-small cell lung cancer is one of the leading causes of cancer-related death in the world. Lung adenocarcinoma, the most common type of non-small cell lung cancer, has been well characterized as having a dense lymphocytic infiltrate, suggesting that ...
Frederick S. Varn, Laura J. Tafe, Christopher I. Amos, Chao Cheng   +3 more
doaj   +1 more source

Identifying Immune Cell Infiltration and Hub Genes During the Myocardial Remodeling Process After Myocardial Infarction

, 2023
Yuan Tian,1,* Zilin Wang,2,* Feng Liang,3,* Yi Wang1 1Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People’s Republic of China; 2Department of Radiology, Shanghai ...
Liang F, Tian Y, Wang Y, Wang Z
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