Results 61 to 70 of about 1,693,225 (311)
Tumor-Infiltrating Immune Cells in Colorectal Cancer [PDF]
NeoplasiaColorectal cancer encompasses a heterogeneous group of malignancies that differ in pathophysiological mechanisms, immune response and infiltration, therapeutic response, and clinical prognosis. Numerous studies have highlighted the clinical relevance of tumor-infiltrating immune cells among different types of colorectal tumors yet vary in cell type ...
Sonia A.M. Ferkel +4 more
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Cell Death Discovery, 2023 The failure of melanoma immunotherapy can be mediated by immunosuppression in the tumor microenvironment (TME), and insufficient activation of effector T cells against the tumor.
Yanan Guo +9 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundLiver hepatocellular carcinoma (HCC) is a prevalent cancer that lacks a sufficiently efficient approach to guide immunotherapy. Additionally, cuproptosis is a recently identified regulated cell death program that is triggered by copper ...
Gongjun Wang +10 more
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Frontiers in Medicine, 2022 Aim N6-methyladenosine (m6A) modification has been demonstrated to play an important part in hepatitis B virus (HBV) infection and immune response. This study aims to further investigate whether m6A modification plays an important role in the progression
Tong Zhao +4 more
semanticscholar +1 more source
BIRC5 is a prognostic biomarker associated with tumor immune cell infiltration
Scientific Reports, 2021 BIRC5 is an immune-related gene that inhibits apoptosis and promotes cell proliferation. It is highly expressed in most tumors and leads to poor prognosis in cancer patients.
Linlong Xu, Wen-Hui Yu, Han Xiao, K. Lin
semanticscholar +1 more source
Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity [PDF]
The Journal of Immunology, 2018 Abstract Limited representation of intratumoral immune cells is a major barrier to tumor control. However, simply enhancing immune responses in tumor-draining lymph nodes or through adoptive transfer may not overcome the limited ability of tumor vasculature to support effector infiltration. An alternative is to promote a sustained immune
Victor H Engelhard +5 more
openaire +2 more sources
The soldiers needed to be awakened: Tumor-infiltrating immune cells
Frontiers in Genetics, 2022 In the tumor microenvironment, tumor-infiltrating immune cells (TIICs) are a key component. Different types of TIICs play distinct roles. CD8+ T cells and natural killer (NK) cells could secrete soluble factors to hinder tumor cell growth, whereas regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) release inhibitory factors to ...
Wang Yaping +13 more
openaire +3 more sources
Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse
OncoImmunology, 2021 A substantial fraction of patients with stage I–III colorectal adenocarcinoma (CRC) experience disease relapse after surgery with curative intent. However, biomarkers for predicting the likelihood of CRC relapse have not been fully explored.
Yasmin Kamal +20 more
doaj +1 more source
Frontiers in Immunology, 2022 Glioblastoma multiforme (GBM) has been identified as a frequently occurring adult primary brain cancer that is highly aggressive. Currently, the prognostic outcome for GBM patients is dismal, even with intensive treatment, and the median overall survival
Peng Feng +4 more
semanticscholar +1 more source
OncoImmunology, 2018 Non-small cell lung cancer is one of the leading causes of cancer-related death in the world. Lung adenocarcinoma, the most common type of non-small cell lung cancer, has been well characterized as having a dense lymphocytic infiltrate, suggesting that ...
Frederick S. Varn +3 more
doaj +1 more source