Results 61 to 70 of about 6,519,090 (301)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Relationship Between Expressions of SDHx Genes and Immune Cell Infiltration in Pheochromocytoma/Paraganglioma

Xiehe Yixue Zazhi
ObjectiveTo investigate the characteristics and differences of immune cell infiltration between different SDHx gene expression and pheochromocytoma/paraganglioma(PPGL).MethodsRNAseqdata of PPGL were downloaded and organized from The Cancer Genome Atlas ...
WANG Pu, GAO Liming, ZHANG Wenyang, YE Ting, LI Hongyan, GUO Rui   +5 more
doaj   +1 more source

Identification and Validation of Immune-Related Genes and Immune Cell Infiltration in Preeclampsia

, 2021
Abstract Background Preeclampsia (PE) is a complex multisystem disease and its etiology remains unclear. The aim of this study was to identify potential immune-related diagnostic genes for PE, analyze the role of immune cell infiltration in PE, and explore the mechanism underlying PE-induced disruption of immune tolerance at the maternal-fetal
Rongxin Chen, Qing Han, Huale Zhang, Jianying Yan   +3 more
openaire   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Correlation analysis of SNX16 and PAPOLG expression with immune infiltration.

, 2022
Correlation of SNX16 (A) and PAPOLG (B) expression with the level of immune cell infiltration. (C) Survival curves to analyze the relationship between six types of immune cell infiltration and overall survival of patients with HCC.
Jing Dai (470985), Jinyan Zhang (759953), Shangshang Hu (10915431), Guoqing Guo (11417031), Yu Gao (69071), Li Zhang (8200)   +5 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

T-Cell Infiltration and Immune Checkpoint Expression Increase in Oral Cavity Premalignant and Malignant Disorders

, 2022
The immune cell niche associated with oral dysplastic lesion progression to carcinoma is poorly understood. We identified T regulatory cells (Treg), CD8(+) effector T cells (Teff) and immune checkpoint molecules across oral dysplastic stages of oral ...
Tu, Andrew A., S. Lynn Sigurdson, Kirkwood, Keith L., Hicks, Wesley L., Wesley L. Hicks, Keith L. Kirkwood, Aboelkheir, Usama, Kuriakose, Moni A., Andrew A. Tu, Moni A. Kuriakose, Usama Aboelkheir, Merzianu, Mihai, Surendran, Subin, Subin Surendran, Magner, William J., William J. Magner, Amritha Suresh, Suresh, Amritha, Sigurdson, S. Lynn, Mihai Merzianu   +19 more
core   +1 more source

Nuf2 Is a Prognostic-Related Biomarker and Correlated With Immune Infiltrates in Hepatocellular Carcinoma

Frontiers in Oncology, 2021
Nuf2 participates in the regulation of cell apoptosis and proliferation by regulating the binding of centromere and spindle microtubules to achieve the correct separation of chromosomes.
Xingwei Xie, Shanshan Jiang, Xiang Li
doaj   +1 more source

Regulation of tumor infiltrated innate immune cells by adenosine

Purinergic Signalling, 2020
Cancer has the ability to escape the immune system using different molecular actors. Adenosine is known to be involved in mechanisms which control inflammatory reactions and prevent excessive immune response. This purine nucleoside can be translocated from the cell or produced in the extracellular space by 5'-ectonucleotidases.
Strakhova, Regina, Cadassou, Octavia, Cros-Perrial, Emeline, Jordheim, Lars Petter   +3 more
openaire   +3 more sources

The immune cell infiltrate in the tumour microenvironment of phaeochromocytomas and paragangliomas

Endocrine-Related Cancer, 2022
Emerging evidence suggests the composition of the tumour microenvironment (TME) correlates with clinical outcome and that each tumour type has a unique TME including a variable population of inflammatory cells. We performed immunohistochemistry on 65 phaeochromocytoma and paraganglioma (PPGL) tumour samples with 20 normal adrenal medulla samples for ...
Tufton, N, Hearnden, R J, Berney, D M, Drake, W M, Parvanta, L, Chapple, J P, Akker, S A   +6 more
openaire   +2 more sources