Results 61 to 70 of about 6,100,412 (305)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Correlation analysis between PLAUR expression and immune cell infiltration.
, 2022 A. Correlation between high and low PLAUR expression and ImmuneScore; B. Correlation between Grade and ImmuneScore; C. Correlation between Stage and ImmuneScore; D. Correlation between T stage and ImmuneScore; E.
Zengshu Xing (12837293) +4 more
core +1 more source
Identification and Validation of Immune-Related Genes and Immune Cell Infiltration in Preeclampsia
, 2021 Abstract Background Preeclampsia (PE) is a complex multisystem disease and its etiology remains unclear. The aim of this study was to identify potential immune-related diagnostic genes for PE, analyze the role of immune cell infiltration in PE, and explore the mechanism underlying PE-induced disruption of immune tolerance at the maternal-fetal
Rongxin Chen +3 more
openaire +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Frontiers in Oncology, 2021 Nuf2 participates in the regulation of cell apoptosis and proliferation by regulating the binding of centromere and spindle microtubules to achieve the correct separation of chromosomes.
Xingwei Xie, Shanshan Jiang, Xiang Li
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
TCGA Pan-Cancer TIMER-based immune cell infiltration abundances
, 2020 TCGA pan-cancer TIMER (Tumor IMmune Estimation Resours)-based immune cell infiltration abundances, including B cell, CD4+ T cell, CD8+ T cell, Dendritic, Macrophage and ...
Yuchen LIU (8672220)
core +1 more source
Regulation of tumor infiltrated innate immune cells by adenosine
Purinergic Signalling, 2020 Cancer has the ability to escape the immune system using different molecular actors. Adenosine is known to be involved in mechanisms which control inflammatory reactions and prevent excessive immune response. This purine nucleoside can be translocated from the cell or produced in the extracellular space by 5'-ectonucleotidases.
Strakhova, Regina +3 more
openaire +3 more sources
The immune cell infiltrate in the tumour microenvironment of phaeochromocytomas and paragangliomas
Endocrine-Related Cancer, 2022 Emerging evidence suggests the composition of the tumour microenvironment (TME) correlates with clinical outcome and that each tumour type has a unique TME including a variable population of inflammatory cells. We performed immunohistochemistry on 65 phaeochromocytoma and paraganglioma (PPGL) tumour samples with 20 normal adrenal medulla samples for ...
Tufton, N +6 more
openaire +2 more sources
BMC Cancer, 2020 Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most common tumor in human. Research has shown that HPV status HNSCC is a unique prognosis factor, which may due to its immune infiltration landscape.
Hao Zeng +5 more
doaj +1 more source