Results 81 to 90 of about 6,519,090 (301)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

TIMER based Spearman correlational analysis between the expression of real hub genes and CD8+ T immune cell infiltration in COAD.

, 2021
TIMER based Spearman correlational analysis between: (A) CXCL12 expression and CD8+ T immune cell infiltration; (B) CXCL8 expression and CD8+ T immune cells’ infiltration; (C) AGT expression and CD8+ T immune cells’ infiltration; (D) GNB1 expression and ...
Shufang Liang (781312), Muhammad Usman (1504405), Samina Ejaz (11378800), Yasir Hameed (8939681)   +3 more
core   +1 more source

Integrated analysis of scRNA-seq and bulk RNA-seq reveals that GPRC5A is an important prognostic gene in pancreatic cancer and is associated with B-cell Infiltration in pancreatic cancer

Frontiers in Oncology
IntroductionPancreatic cancer (PC) is a malignancy with poor prognosis. This investigation aimed to determine the relevant genes that affect the prognosis of PC and investigate their relationship with immune infiltration.Methods: First, we acquired PC ...
Chunlu Dong, Chunlu Dong, Haidong Ma, Ningning Mi, Wenkang Fu, Jianfeng Yi, Jianfeng Yi, Long Gao, Haiping Wang, Haiping Wang, Yanxian Ren, Yanxian Ren, Yanyan Lin, Yanyan Lin, Fangfang Han, Fangfang Han, Zhou Chen, Zhou Chen, Wence Zhou, Wence Zhou   +19 more
doaj   +1 more source

Comprehensive Analysis of RUNX and TGF-β Mediated Regulation of Immune Cell Infiltration in Breast Cancer

Frontiers in Cell and Developmental Biology, 2021
Runt-related transcription factors (RUNXs) can serve as both transcription activators and repressors during biological development, including immune cell maturation.
Liang Gao, Fangfang Zhou
doaj   +1 more source

Immune Cell Infiltrates in Atypical Teratoid/Rhabdoid Tumors [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2012
Objective:Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant tumor of the central nervous system. Its pathogenesis remains unknown. Like glioblastomas, AT/RTs contain brain cancer stem cells (CSCs) that suppress the immunity of patients and are resistant to conventional chemotherapy and radiation therapy. Considerable infiltration of immune
Jian-Qiang, Lu, Beverly A, Wilson, V Wee, Yong, Jeffrey, Pugh, Vivek, Mehta   +4 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Leveraging machine learning models to evaluate immune infiltration in the ovarian cancer microenvironment: a single-cell analysis approach

Discover Oncology
Background The prognosis of ovarian cancer is closely related to the degree of immune cell infiltration within the tumor microenvironment. However, current methods for assessing immune infiltration have certain subjective limitations. This study aimed to
Jie Liu, Baoguo Xia, Bingxin Li, Hui Liang   +3 more
doaj   +1 more source

DNA alteration‐based classification of uveal melanoma gives better prognostic stratification than immune infiltration, which has a neutral effect in high‐risk group

Cancer Medicine, 2019
Background In uveal melanomas, immune infiltration is a marker of poor prognosis. This work intended to decipher the biological characteristics of intra‐tumor immune population, compare it to other established biomarkers and to patients' outcome. Methods
Deepti Narasimhaiah, Catherine Legrand, Diane Damotte, Romain Remark, Marco Munda, Patrick De Potter, Pierre G. Coulie, Miikka Vikkula, Catherine Godfraind   +8 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Cuproptosis-related modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of kidney renal clear cell carcinoma

Frontiers in Immunology, 2022
BackgroundDue to the different infiltration abundance of immune cells in tumor, the efficacy of immunotherapy varies widely among individuals. Recently, growing evidence suggested that cuproptosis has impact on cancer immunity profoundly.
Zhiyong Cai, You'e He, Zhengzheng Yu, Jiao Hu, Zicheng Xiao, Xiongbing Zu, Zhenghao Li, Huihuang Li   +7 more
doaj   +1 more source