Results 131 to 140 of about 1,650,706 (352)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution

Journal of Experimental & Clinical Cancer Research
Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain immune cells can impair this response and help tumor immune escape. Therefore, exploring the factors that influence
Wenhui Yang, Shimao Liu, Mengyun Mao, Yandong Gong, Xiaohui Li, Tianyu Lei, Chao Liu, Shikai Wu, Qinyong Hu   +8 more
doaj   +1 more source

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]

, 2018
Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D, Chavez, Michael, Davis, Ryan R, Ferrara, Katherine W, Fite, Brett Z, Hubbard, Neil E, Ilovitsh, Asaf, Ingham, Elizabeth S, Mahakian, Lisa M, Monjazeb, Arta M, Murphy, William J, Silvestrini, Matthew T, Tam, Sarah M, Tepper, Clifford G   +13 more
core   +1 more source

Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity

Nature Communications, 2020
Immune-therapy is an attractive alternative therapeutic approach for targeting central nervous system (CNS) tumors and the constituency of the Tumor Immune Microenvironment (TIME) likely to predict patient response.
Y. Grabovska, A. Mackay, P. O’Hare, S. Crosier, M. Finetti, E. Schwalbe, J. Pickles, Amy R. Fairchild, A. Avery, J. Cockle, Rebecca M Hill, J. Lindsey, D. Hicks, M. Kristiansen, J. Chalker, John Anderson, D. Hargrave, T. Jacques, K. Straathof, S. Bailey, Chris Jones, S. Clifford, D. Williamson   +22 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Prognostic value of tumor immune cell infiltration patterns in colon adenocarcinoma based on systematic bioinformatics analysis [PDF]

, 2021
Hao Xu, Qianhui Xu, Lu Yin
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Low expression of PRRG2 in kidney renal clear cell carcinoma: an immune infiltration-associated prognostic biomarker

Discover Oncology
Objective This study aims to explore the prognostic significance of Proline-rich γ-carboxyglutamic acid protein 2 (PRRG2) in Kidney Renal Clear Cell Carcinoma (KIRC), a prevalent and deadly cancer, and its association with immune cell infiltration, a key
Gonglin Tang, Guixin Ding, Gang Wu, Xiaofeng Wang, Tianqi Wang, Qingsong Zou, Kai Sun, Jitao Wu   +7 more
doaj   +1 more source

Immunonutrition before esophagectomy: Impact on immune surveillance mechanisms [PDF]

, 2017
Preoperative oral immunonutrition was demonstrated to improve immune response and to decrease the infection rate in patients with cancer. This study aimed to assess how immunonutrition could influence the immune cell response in the mucosal ...
Agostini, Marco, Alfieri, Rita, Cagol, Matteo, Castagliuolo, Ignazio, Castoro, Carlo, Cavallin, Francesco, Fassan, Matteo, Kotsafti, Andromachi, Nardi, Teresa, Pinto, Eleonora, Rugge, Massimo, Scarpa, Marco, Scarpa, Melania   +12 more
core   +1 more source

Identification of key pathways, genes and immune cell infiltration in hypoxia of high-altitude acclimatization via meta-analysis and integrated bioinformatics analysis [PDF]

, 2023
Qiong Li, Zhichao Xu, Fujin Fang, Yan Shen, Huan Lei, Xiaobing Shen   +5 more
openalex   +1 more source