Results 201 to 210 of about 85,902 (266)

Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade. [PDF]

Nat Med
Gonzalez-Kozlova E, Sweeney R, Figueiredo I, Tuballes K, Ozbey S, Hamon P, Park MD, Ioannou G, Nose Y, Guo R, Restrepo P, Buckup M, Roudko V, Hennequin C, Le Berichel J, Venturini N, Halasz L, Troncoso L, Tabachnikova A, Chang C, Reid A, Brown H, Chin T, Cabal R, Mattiuz R, Eikawa S, Del Valle DM, Gonsalves TR, LaMarche NM, Jamal H, Lansky A, Yi N, Nelson D, Morgenroth-Rebin J, Merand R, Villagomez B, D'Souza D, Radkevich E, Nie K, Chen Z, Tada Y, Nishikawa H, Ward SC, Fiel MI, Brody R, Tabrizian P, Gunasekaran G, Kamphorst AO, Cohen N, Curotto de Lafaille M, Hapanowicz O, Lucas N, Wu K, James N, Lin JC, Thurston G, Schwartz M, Fiaschi N, Kim-Schulze S, Merad M, Marron TU, Gnjatic S.   +61 more
europepmc   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Predictors of Immune Checkpoint Blockade Response in dMMR Colorectal Cancer Using an Integrated Immune-Enhanced Multi-Omics Platform. [PDF]

Clin Cancer Res
Sinicrope FA, Sharma N, Mohiuddin M, Saberzadeh-Ardestani B, Graham RP, Lewis JT, Li B, Abbott CW, Boyle SM.   +8 more
europepmc   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

Complete response to immune checkpoint blockade in sarcomatoid renal cell carcinoma with bone marrow metastasis: case report with tumor immune microenvironment profiling. [PDF]

J Immunother Cancer
Miura Y, Jikuya R, Saijo A, Yano H, Kinowaki K, Takemura K, Uchino K, Hasumi H, Komohara Y.   +8 more
europepmc   +1 more source

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

Author Correction: Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer. [PDF]

NPJ Breast Cancer
Draganov D, Han Z, Rana A, Bennett N, Irvine DJ, Lee PP.   +5 more
europepmc   +1 more source

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

Exceptional response of radiotherapy-naïve cranial meningiomas to dual immune checkpoint blockade in BAP1 tumor predisposition syndrome. [PDF]

Neurooncol Adv
Gallia GL, Hann CL, Lucas CG, Luna LP, Kamson DO, Sato T.   +5 more
europepmc   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source