Results 211 to 220 of about 85,902 (266)

The tumor microenvironment's role in the response to immune checkpoint blockade. [PDF]

Nat Cancer
Aliazis K, Christofides A, Shah R, Yeo YY, Jiang S, Charest A, Boussiotis VA.   +6 more
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Ferroptotic tumor cells reprogram tumor-associated macrophage antigen presentation to enhance the efficacy of immune checkpoint blockade. [PDF]

Cell Rep Med
Sun JL, Chu YC, Wang F, Yu DD, Liu JR, Xu RC, Liu HH, Qi ZR, Shi X, Yu XN, Yao YK, Liu TT, Weng SQ, Dong L, Shen XZ, Hu SB, Sun T, Zhu JM.   +17 more
europepmc   +1 more source

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

Integrated Single-Cell and Spatial Analysis Reveals Context-Dependent Myeloid-T Cell Interactions in Response to Immune Checkpoint Blockade in Head and Neck Cancer. [PDF]

Clin Cancer Res
Golfinos-Owens AE, Lozar T, Khatri P, Johns ED, Hu R, Harari PM, Lambert PF, Fitzpatrick MB, Dinh HQ.   +8 more
europepmc   +1 more source

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

Abrogation of Oncogenic RAS Signaling by a RAS(ON) Inhibitor Doublet Primes Immune-Refractory KRASG12C-Mutant NSCLC for Immune Checkpoint Blockade. [PDF]

Cancer Discov
Wei X, Blaj C, Ali Al-Radhawi M, Lai LP, Maldonato BJ, Yang YC, Seu L, Gundlapalli H, Jiang L, Moreno Ayala MA, Spradlin JN, Garrick B, Cai S, Salmon A, Pham A, Bredeson S, Liang R, Helland C, Evans JW, Labrecque MP, Yu X, Song AHJ, Dinglasan N, Tran L, Kumamoto A, Grigoryan L, Malliri A, Brown KD, Carter M, Simpson KL, Crosbie PA, Galvin M, Chang S, Huang Y, Tovbis Shifrin N, Pechuan-Jorge X, Raghulan R, Zhuang Y, Coles DI, Dive C, Aronchik I, Holderfield M, Lindsay CR, Wang Z, Wang Z, Singh M, Smith JAM, Jiang J, Quintana E.   +48 more
europepmc   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Toxicity and treatment discontinuation with adjuvant immune checkpoint blockade: a correspondence. [PDF]

Int J Surg
Zhong R, Huang L, Tang P.
europepmc   +1 more source

Determinants of Response to Immune Checkpoint Blockade in Pleural Mesothelioma: Molecular, Immunological, and Clinical Perspectives. [PDF]

Cancers (Basel)
Delsignore M, Cassinari G, Revello S, Cerbone L, Grosso F, Arsura M, Porta C.   +6 more
europepmc   +1 more source