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LIGHT May Improve Immune Checkpoint Blockade Response
Cancer Discovery, 2016Abstract A new study suggests that insufficient T-cell infiltration may explain why a majority of patients do not respond to immunotherapy. Combining PD-L1 inhibitors with antibody-guided LIGHT, a protein that recruits tumor-infiltrating lymphocytes, increased antitumor response in mice, and may have the potential to improve patient ...
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A review of cancer immunotherapy toxicity
Ca-A Cancer Journal for Clinicians, 2020Lucy Boyce Kennedy
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Neoadjuvant immune checkpoint blockade: A window of opportunity to advance cancer immunotherapy
Cancer Cell, 2023Suzanne L Topalian +2 more
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Immune Checkpoint Blockade Response Biomarkers
2023María Garrido-Barros +2 more
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Dynamic versus static biomarkers in cancer immune checkpoint blockade: unravelling complexity
Nature Reviews Drug Discovery, 2017Willem J Lesterhuis +2 more
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AMPK and immune checkpoint blockade
AMPK is a key sensor of energy stress, acting as a master regulator of cell metabolism. This protein is a heterotrimeric serine-threonine kinase which controls the inhibition of anabolic pathways and activation of catabolic pathways to maintain celular energy levels.Valentines-Casas, Gerard +1 more
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Monitoring immune-checkpoint blockade: response evaluation and biomarker development
Nature Reviews Clinical Oncology, 2017Mizuki Nishino +2 more
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An update on the immune landscape in lung and head and neck cancers
Ca-A Cancer Journal for Clinicians, 2020Jennifer W Carlisle +2 more
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