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Vaccination-enabled immune readiness for checkpoint blockade [PDF]

Frontiers in Immunology
Immune checkpoint blockade has transformed cancer therapy by demonstrating that durable tumour control can be achieved through immune modulation rather than direct cytotoxicity.
Jhommara Bautista, Andrés López-Cortés   +1 more
doaj   +2 more sources

A landscape of checkpoint blockade resistance in cancer: underlying mechanisms and current strategies to overcome resistance

Cancer Biology and Therapy
The discovery of immune checkpoints and the development of immune checkpoint inhibitors (ICI) have achieved a durable response in advanced-stage cancer patients.
J W Hodge, Kellsye Fabian, Ginette Santiago-Sanchez   +2 more
exaly   +3 more sources

Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T cell responses in a murine acute myeloid leukemia model

Haematologica, 2021
We have developed a personalized vaccine whereby patient derived leukemia cells are fused to autologous dendritic cells, evoking a polyclonal T cell response against shared and neo-antigens.
Dina Stroopinsky, Jessica Liegel, Manoj Bhasin, Giulia Cheloni, Beena Thomas, Swati Bhasin, Ruchit Panchal, Haider Ghiasuddin, Maryam Rahimian, Myrna Nahas, Shira Orr, Marzia Capelletti, Daniela Torres, Cansu Tacettin, Matthew Weinstock, Lina Bisharat, Adam Morin, Kathleen M. Mahoney, Benjamin Ebert, Richard Stone, Donald Kufe, Gordon J. Freeman, Jacalyn Rosenblatt, David Avigan   +23 more
doaj   +1 more source

A PD-L1 Negative Advanced Gastric Cancer Patient With a Long Response to PD-1 Blockade After Failure of Systematic Treatment: A Case Report

Frontiers in Immunology, 2021
BackgroundIt was widely accepted that programmed death-ligand 1 (PD-L1) positive, tumor mutational burden-high (TMB-H) or microsatellite instability-high (MSI-H) tumor are prone to have better treatment response to immune checkpoint blockade.
Fangyuan Zhang, Jieying Zhang, Lei Zhao, Menglan Zhai, Tao Zhang, Dandan Yu   +5 more
doaj   +1 more source

PD-1 and LAG-3 blockade improve anti-tumor vaccine efficacy

OncoImmunology, 2021
Concurrent blockade of different checkpoint receptors, notably PD-1 and CTLA-4, elicits greater anti-tumor activity for some tumor types, and the combination of different checkpoint receptor inhibitors is an active area of clinical research.
Christopher D. Zahm, Jena E Moseman, Lauren E. Delmastro, Douglas G. Mcneel   +3 more
doaj   +1 more source

Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40

Nature Communications, 2021
Glioblastomas are generally resistant to treatment with immune checkpoint inhibitors. Here the authors show that IL6 blockade, in combination with a CD40 agonist, overcomes macrophage-mediated immunosuppression and sensitizes glioblastoma to immune ...
Fan Yang, Zhenqiang He, Hao Duan, Duo Zhang, Juehui Li, Huijuan Yang, Jay F. Dorsey, Wei Zou, S. Ali Nabavizadeh, Stephen J. Bagley, Kalil Abdullah, Steven Brem, Lin Zhang, Xiaowei Xu, Katelyn T. Byrne, Robert H. Vonderheide, Yanqing Gong, Yi Fan   +17 more
doaj   +1 more source

Epitherapy and immune checkpoint blockade: using epigenetic reinvigoration of exhausted and dysfunctional T cells to reimburse immunotherapy response

BMC Immunology, 2020
Background Cancer cells subvert natural immunosuppression by upregulating the expression of checkpoint proteins and their ligands. For example, tumor cells expressing programmed death-ligand 1 (PD-L1) induce immune cell tolerance to cancers, thereby ...
Isabella McGoverne, Jenny Dunn, Jacob Batham, Wen Juan Tu, Jeremy Chrisp, Sudha Rao   +5 more
doaj   +1 more source

Enhancing the efficacy of immunotherapy using radiotherapy

Clinical & Translational Immunology, 2020
Recent clinical breakthroughs in cancer immunotherapy, especially with immune checkpoint blockade, offer great hope for cancer sufferers – and have greatly changed the landscape of cancer treatment.
Synat Keam, Suki Gill, Martin A Ebert, Anna K Nowak, Alistair M Cook   +4 more
doaj   +1 more source

Combined immune checkpoint blockade increases CD8+CD28+PD-1+ effector T cells and provides a therapeutic strategy for patients with neuroblastoma

OncoImmunology, 2021
Immune checkpoint therapy has resulted in minimal clinical response in many pediatric cancers. We sought to understand the influence of immune checkpoint inhibition using anti-PD-1 and anti-CTLA-4 antibodies individually, in combination, and after ...
Soheila Shirinbak, Randall Y. Chan, Shilpa Shahani, Sakunthala Muthugounder, Rebekah Kennedy, Long T. Hung, G. Esteban Fernandez, Michael D. Hadjidaniel, Babak Moghimi, Michael A. Sheard, Alan L. Epstein, Muller Fabbri, Hiroyuki Shimada, Shahab Asgharzadeh   +13 more
doaj   +1 more source

Improving cancer immunotherapy via co-delivering checkpoint blockade and thrombospondin-1 downregulator

Acta Pharmaceutica Sinica B, 2023
The use of checkpoint-blockade antibodies is still restricted in several malignancies due to the modest efficacy, despite considerable success in anti-tumor immunotherapy.
Qingqing Xiao, Xiaotong Li, Chang Liu, Yuxin Jiang, Yonglong He, Wanting Zhang, Helena S. Azevedo, Wei Wu, Yuanzheng Xia, Wei He   +9 more
doaj   +1 more source