Results 21 to 30 of about 289,858 (293)

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses. [PDF]

, 1998
Eukaryotic cells respond to DNA damage and S phase replication blocks by arresting cell-cycle progression through the DNA structure checkpoint pathways.
Lindsay, Howard D., Flaggs, Gail, Martinho, Rui G., Carr, Antony M., DeMaggio, Anthony J, Bentley, Nicola J., Hoekstra, Merl F.   +6 more
core   +4 more sources

Immune checkpoint blockade therapy [PDF]

Journal of Allergy and Clinical Immunology, 2018
Immune checkpoints are accessory molecules that either promote or inhibit T-cell activation. Two inhibitory molecules, cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), got high attention, as inhibition of CTLA-4 or PD-1 signaling provides the first immune therapy that significantly improves the survival of patients ...
Thomas, Wieder, Thomas, Eigentler, Ellen, Brenner, Martin, Röcken   +3 more
openaire   +2 more sources

Hyperprogression: A novel response pattern under immunotherapy

Clinical and Translational Medicine, 2020
Checkpoint blockade therapy has shown significant therapeutic benefits and resulted in durable responses in patients with various tumors. However, accumulating evidence has demonstrated that 4‐29% of all patients with cancers with various histologies may
Xue‐jiao Han, Aqu Alu, Yi‐nan Xiao, Yu‐quan Wei, Xia‐wei Wei   +4 more
doaj   +1 more source

Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma

Nature Communications, 2021
Immune-checkpoint blockade has shown limited benefits in patients with glioblastoma. To understand how the composition of the tumor immune microenvironment might limit clinical responses, here the authors present a high dimensional profiling of the ...
Alexander H. Lee, Lu Sun, Aaron Y. Mochizuki, Jeremy G. Reynoso, Joey Orpilla, Frances Chow, Jenny C. Kienzler, Richard G. Everson, David A. Nathanson, Steven J. Bensinger, Linda M. Liau, Timothy Cloughesy, Willy Hugo, Robert M. Prins   +13 more
doaj   +1 more source

The miRNA Profile of Inflammatory Colorectal Tumors Identify TGF-β as a Companion Target for Checkpoint Blockade Immunotherapy

Frontiers in Cell and Developmental Biology, 2021
Extrinsic factors such as expression of PD-L1 (programmed dealth-ligand 1) in the tumor microenvironment (TME) have been shown to correlate with responses to checkpoint blockade therapy.
Bjarne Bartlett, Bjarne Bartlett, Zitong Gao, Zitong Gao, Monique Schukking, Monique Schukking, Mark Menor, Vedbar S. Khadka, Muller Fabbri, Peiwen Fei, Youping Deng, Youping Deng   +11 more
doaj   +1 more source

Bub3p facilitates spindle checkpoint silencing in fission yeast [PDF]

, 2009
Although critical for spindle checkpoint signaling, the role kinetochores play in anaphase promoting complex (APC) inhibition remains unclear. Here we show that spindle checkpoint proteins are severely depleted from unattached kinetochores in fission ...
Hardwick, Kevin G., Millar, Jonathan B.A., van der Sar, Sjaak J. A., van der Sar, Sjaak J A, van Der Sar, Sjaak J.A., Millar, Jonathan B. A., Vanoosthuyse, Vincent, Millar, Jonathan B A, Meadows, John C, Vanoosthuyse, V., Hardwick, Kevin, Meadows, John, Meadows, John C., Hardwick, Kevin G   +13 more
core   +1 more source

Checkpoint blockade in lymphoma [PDF]

Hematology, 2015
AbstractImmune checkpoint blockade therapy (CBT) was born of the combination of several elements: the understanding of some of the important immune regulation pathways in humans; the recognition that tumors can engage those pathways to evade immune responses; and the clinical development of monoclonal antibodies targeting checkpoint receptors to ...
openaire   +2 more sources

Checkpoint proteins come under scrutiny [PDF]

, 2013
Details are emerging of the interactions between the kinetochore and various spindle checkpoint proteins that ensure that sister chromatids are equally divided between daughter cells during cell ...
Jonathan BA Millar, Mora-Santos, Maria, Millar, Jonathan B. A., Maria Mora-Santos   +3 more
core   +1 more source

Antitumor efficacy of combined CTLA4/PD-1 blockade without intestinal inflammation is achieved by elimination of FcγR interactions

Journal for ImmunoTherapy of Cancer, 2020
Background Programmed cell death protein 1 (PD-1) and CTLA4 combination blockade enhances clinical efficacy in melanoma compared with targeting either checkpoint alone; however, clinical response improvement is coupled with increased risk of developing ...
Peng Yang, Wendy Blumenschein, David Bauché, Smita Mauze, Christina Kochel, Jeff Grein, Anandi Sawant, Yulia Zybina, Lakshmanan Annamalai, Jennifer H Yearley, Juha Punnonen, Edward P Bowman, Alissa Chackerian, Drake Laface   +13 more
doaj   +1 more source

Recent Advances of Immune Checkpoint Inhibition and Potential for (Combined) TIGIT Blockade as a New Strategy for Malignant Pleural Mesothelioma

Biomedicines, 2022
Malignant pleural mesothelioma (MPM) is a fatal cancer type that affects the membranes lining the lungs, and is causally associated with asbestos exposure. Until recently, the first-line treatment consisted of a combination of chemotherapeutics that only
Sophie Rovers, Annelies Janssens, Jo Raskin, Patrick Pauwels, Jan P. van Meerbeeck, Evelien Smits, Elly Marcq   +6 more
doaj   +1 more source