Results 11 to 20 of about 289,858 (293)
Immune checkpoint blockade in HIV
eBioMedicine, 2022 Antiretroviral therapy (ART) has dramatically improved life expectancy for people with HIV (PWH) and helps to restore immune function but is not curative and must be taken lifelong. Achieving long term control of HIV in the absence of ART will likely require potent T cell function, but chronic HIV infection is associated with immune exhaustion that ...
Gubser, C +3 more
openaire +6 more sources
Advanced Nanotechnology for Enhancing Immune Checkpoint Blockade Therapy [PDF]
Nanomaterials, 2021 Immune checkpoint receptor signaling pathways constitute a prominent class of “immune synapse,” a cell-to-cell connection that represses T-lymphocyte effector functions.
Chiara Cremolini +3 more
doaj +3 more sources
Radiotherapy Complements Immune Checkpoint Blockade [PDF]
Cancer Cell, 2015 Adaptive immune resistance ablates effective anti-tumor immune responses. In a recent issue of Nature, Victor and colleagues describe that anti-PD-L1 combats adaptive immune resistance upon localized radiation plus anti-CTLA-4 therapy. The superior activity of radiation and dual immune checkpoint blockade is mediated by non-redundant immune mechanisms ...
Ngiow, Shin Foong +2 more
openaire +7 more sources
Journal of Immunology Research, 2018 Tumor is the most serious threat to human beings. Although war against cancer has been launched over forty years, cancer treatment is still far away from being satisfactory.
Huan Zhao +3 more
doaj +2 more sources
MCT4 blockade increases the efficacy of immune checkpoint blockade
Journal for ImmunoTherapy of Cancer, 2023 Background & Aims Intratumoral lactate accumulation and acidosis impair T-cell function and antitumor immunity. Interestingly, expression of the lactate transporter monocarboxylate transporter (MCT) 4, but not MCT1, turned out to be prognostic for ...
Christian Schmidl +25 more
doaj +3 more sources
Interleukin-34 Limits the Therapeutic Effects of Immune Checkpoint Blockade
iScience, 2020 Summary: Interleukin-34 (IL-34) is an alternative ligand to colony-stimulating factor-1 (CSF-1) for the CSF-1 receptor that acts as a key regulator of monocyte/macrophage lineage.
Naoki Hama +12 more
doaj +2 more sources
Combination approaches with immune checkpoint blockade in cancer therapy [PDF]
Frontiers in Oncology, 2016 In healthy individuals, immune checkpoint molecules prevent autoimmune responses and limit immune cell-mediated tissue damage. Tumors frequently exploit these molecules to evade eradication by the immune system.
Maarten Swart +2 more
doaj +2 more sources
DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. [PDF]
, 2002 Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the ...
Lindsay, Howard D. +3 more
core +5 more sources
Myocarditis with Immune Checkpoint Blockade [PDF]
New England Journal of Medicine, 2017 In their discussion of fulminant myocarditis and complete heart block during immune checkpoint therapy, Johnson et al. do not discuss the possible role of circulating anticonductive tissue autoantibodies (ACTA) in the pathogenesis of the sudden heart block and myocarditis.1 Since it is not known which autoantigens (other than troponin I, which was ...
Javid J, Moslehi +2 more
openaire +5 more sources
A direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling. [PDF]
, 2006 TopBP1-like proteins, which include Xenopus laevis Xmus101, are required for DNA replication and have been linked to replication checkpoint control. A direct role for TopBP1/Mus101 in checkpoint control has been difficult to prove, however, because of ...
Lindsay, Howard D. +5 more
core +5 more sources