Results 41 to 50 of about 85,902 (266)

Combination approaches with immune checkpoint blockade in cancer therapy

Frontiers in Oncology, 2016
In healthy individuals, immune checkpoint molecules prevent autoimmune responses and limit immune cell-mediated tissue damage. Tumors frequently exploit these molecules to evade eradication by the immune system.
Maarten Swart, Inge Verbrugge, Joost Beltman   +2 more
doaj   +1 more source

Activation of phagocytosis by immune checkpoint blockade [PDF]

Frontiers of Medicine, 2018
Inhibition of macrophage-mediated phagocytosis has emerged as an essential mechanism for tumor immune evasion. One mechanism inhibiting the innate response is the presence of the macrophage inhibitory molecule, signal regulatory protein-α (SIRPα), on tumor-associated macrophages (TAMs) and its cognate ligand cluster of differentiation 47 (CD47) on ...
Li, Chia-Wei, Lai, Yun-Ju, Hsu, Jennifer L., Hung, Mien-Chie   +3 more
openaire   +2 more sources

Radiation combines with immune checkpoint blockade to enhance T cell priming in a murine model of poorly immunogenic pancreatic cancer

Open Biology, 2021
Radiation has been a pillar of cancer therapy for decades. The effects of radiation on the anti-tumour immune response are variable across studies and have not been explicitly defined in poorly immunogenic tumour types.
Courtney T. Stump, Kevin Roehle, Nataly Manjarrez Orduno, Stephanie K. Dougan   +3 more
doaj   +1 more source

Successful Treatment of Myasthenia Gravis Following PD-1/CTLA-4 Combination Checkpoint Blockade in a Patient With Metastatic Melanoma

Frontiers in Oncology, 2019
Currently, the blockade of certain immune checkpoints such as the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death-1 (PD-1) using checkpoint inhibitors is standard of care in patients with metastatic melanoma, especially ...
Jan-Michael Werner, Viola Schweinsberg, Michael Schroeter, Michael Schroeter, Boris von Reutern, Michael P. Malter, Max Schlaak, Max Schlaak, Gereon R. Fink, Gereon R. Fink, Cornelia Mauch, Cornelia Mauch, Norbert Galldiks, Norbert Galldiks, Norbert Galldiks   +14 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A combination of protein phosphatase 2A inhibition and checkpoint immunotherapy: a perfect storm

Molecular Oncology
Immune checkpoint blockade has emerged as a potent new tool in the war on cancer. However, only a subset of cancer patients benefit from this therapeutic modality, sparking a search for combination therapies to increase the fraction of responding ...
Mary C. Clark, Rongze Olivia Lu, Winson S. Ho, Matheus Henrique Dias, René Bernards, Stephen J. Forman   +5 more
doaj   +1 more source

The miRNA Profile of Inflammatory Colorectal Tumors Identify TGF-β as a Companion Target for Checkpoint Blockade Immunotherapy

Frontiers in Cell and Developmental Biology, 2021
Extrinsic factors such as expression of PD-L1 (programmed dealth-ligand 1) in the tumor microenvironment (TME) have been shown to correlate with responses to checkpoint blockade therapy.
Bjarne Bartlett, Bjarne Bartlett, Zitong Gao, Zitong Gao, Monique Schukking, Monique Schukking, Mark Menor, Vedbar S. Khadka, Muller Fabbri, Peiwen Fei, Youping Deng, Youping Deng   +11 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Facts and Perspectives: Implications of tumor glycolysis on immunotherapy response in triple negative breast cancer

Frontiers in Oncology, 2023
Triple negative breast cancer (TNBC) is an aggressive disease that is difficult to treat and portends a poor prognosis in many patients. Recent efforts to implement immune checkpoint inhibitors into the treatment landscape of TNBC have led to improved ...
Ashley Schreier, Roberta Zappasodi, Roberta Zappasodi, Roberta Zappasodi, Inna Serganova, Inna Serganova, Kristy A. Brown, Sandra Demaria, Eleni Andreopoulou   +8 more
doaj   +1 more source