Results 21 to 30 of about 1,265,615 (248)

Programmed Cell Death Protein 1 Axis Inhibition in Viral Infections: Clinical Data and Therapeutic Opportunities

Vaccines, 2022
A vital function of the immune system is the modulation of an evolving immune response. It is responsible for guarding against a wide variety of pathogens as well as the establishment of memory responses to some future hostile encounters. Simultaneously,
Konstantinos Tsiakos, Niki Gavrielatou, Ioannis A. Vathiotis, Loukas Chatzis, Stamatios Chatzis, Garyfallia Poulakou, Elias Kotteas, Nikolaos K. Syrigos   +7 more
doaj   +1 more source

Immune Checkpoint Inhibitors in Triple Negative Breast Cancer Treatment: Promising Future Prospects

Frontiers in Oncology, 2021
Immunotherapy has emerged as the fifth pillar of cancer treatment alongside surgery, radiotherapy, chemotherapy, and targeted therapy. Immune checkpoint inhibitors are the current superheroes of immunotherapy, unleashing a patient’s own immune cells to ...
Remy Thomas, Ghaneya Al-Khadairi, Ghaneya Al-Khadairi, Julie Decock, Julie Decock   +4 more
doaj   +1 more source

PD-1 and LAG-3 Checkpoint Blockade: Potential Avenues for Therapy in B-Cell Lymphoma

Cells, 2021
The dependence of cancer on an immunotolerant tumor microenvironment (TME) is well established. Immunotherapies that overcome tumor-induced immune suppression have been central to recent advancements in oncology.
Joshua W. D. Tobin, Karolina Bednarska, Ashlea Campbell, Colm Keane   +3 more
doaj   +1 more source

Intradermal DNA vaccination combined with dual CTLA-4 and PD-1 blockade provides robust tumor immunity in murine melanoma.

PLoS ONE, 2019
We aimed to explore whether the combination of intradermal DNA vaccination, to boost immune response against melanoma antigens, and immune checkpoint blockade, to alleviate immunosuppression, improves antitumor effectiveness in a murine B16F10 melanoma ...
Spela Kos, Alessandra Lopes, Veronique Preat, Maja Cemazar, Ursa Lampreht Tratar, Bernard Ucakar, Kevin Vanvarenberg, Gregor Sersa, Gaelle Vandermeulen   +8 more
doaj   +1 more source

Dual CTLA-4 and PD-L1 Blockade Inhibits Tumor Growth and Liver Metastasis in a Highly Aggressive Orthotopic Mouse Model of Colon Cancer

Neoplasia: An International Journal for Oncology Research, 2019
Immune checkpoint inhibitors have shown clinical benefit in several cancer entities including metastatic microsatellite instable colorectal carcinomas. However, for the majority of metastatic colorectal carcinomas the potential and limitations of immune ...
E Fiegle, D Doleschel, S Koletnik, A Rix, R Weiskirchen, E Borkham-Kamphorst, F Kiessling, W Lederle   +7 more
doaj   +1 more source

The Role of Immune Checkpoint Molecules on Macrophages in Cancer, Infection, and Autoimmune Pathologies

Frontiers in Immunology, 2022
Immune checkpoint inhibitors have revolutionized immunotherapy against various cancers over the last decade. The use of checkpoint inhibitors results in remarkable re-activation of patients’ immune system, but is also associated with significant adverse ...
Victoria C. Brom, Christof Burger, Dieter C. Wirtz, Frank A. Schildberg   +3 more
doaj   +1 more source

Nucleic acid-based immune checkpoint blockade: Progress and potential

, 2021
Engaging the immune system through checkpoint blockade has become a standard of care in the treatment of many tumors. Traditionally, immune checkpoint blockade involves the use of monoclonal antibodies and whilst these have been extremely successful ...
Adam A. Walters, Walters, Adam A., Baljevan Dhadwar, Dhadwar, Baljevan, Khuloud T. Al-Jamal, Al-Jamal, Khuloud T.   +5 more
core   +1 more source

Improving cancer immunotherapy via co-delivering checkpoint blockade and thrombospondin-1 downregulator

Acta Pharmaceutica Sinica B, 2023
The use of checkpoint-blockade antibodies is still restricted in several malignancies due to the modest efficacy, despite considerable success in anti-tumor immunotherapy.
Qingqing Xiao, Xiaotong Li, Chang Liu, Yuxin Jiang, Yonglong He, Wanting Zhang, Helena S. Azevedo, Wei Wu, Yuanzheng Xia, Wei He   +9 more
doaj   +1 more source

Radiotherapy Complements Immune Checkpoint Blockade [PDF]

, 2015
Adaptive immune resistance ablates effective anti-tumor immune responses. In a recent issue of Nature, Victor and colleagues describe that anti-PD-L1 combats adaptive immune resistance upon localized radiation plus anti-CTLA-4 therapy.
Ngiow, Shin Foong, McArthur, Grant A., Smyth, Mark J.   +2 more
core   +1 more source

Dissecting peripheral CD8+ T cell responses and immune interactions during immune checkpoint blockade for metastatic melanoma [PDF]

, 2023
Immune checkpoint blockade has provided a revolution in solid cancer treatment particularly in the metastatic setting. Although many patients demonstrate clinical responses upon receiving checkpoint therapy, a considerable number of individuals fail to ...
Tong, Orion
core   +1 more source