Results 11 to 20 of about 85,902 (266)

Immune checkpoint blockade in HIV

EBioMedicine, 2022
Summary: Antiretroviral therapy (ART) has dramatically improved life expectancy for people with HIV (PWH) and helps to restore immune function but is not curative and must be taken lifelong.
Celine Gubser, Chris Chiu, Sharon R. Lewin, Thomas A. Rasmussen   +3 more
doaj   +5 more sources

Myocarditis with Immune Checkpoint Blockade [PDF]

New England Journal of Medicine, 2017
In their discussion of fulminant myocarditis and complete heart block during immune checkpoint therapy, Johnson et al. do not discuss the possible role of circulating anticonductive tissue autoantibodies (ACTA) in the pathogenesis of the sudden heart block and myocarditis.1 Since it is not known which autoantigens (other than troponin I, which was ...
Javid J, Moslehi, Douglas B, Johnson, Jeffrey A, Sosman   +2 more
openaire   +5 more sources

Immune checkpoint blockade therapy [PDF]

Journal of Allergy and Clinical Immunology, 2018
Immune checkpoints are accessory molecules that either promote or inhibit T-cell activation. Two inhibitory molecules, cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), got high attention, as inhibition of CTLA-4 or PD-1 signaling provides the first immune therapy that significantly improves the survival of patients ...
Thomas, Wieder, Thomas, Eigentler, Ellen, Brenner, Martin, Röcken   +3 more
openaire   +2 more sources

Radiotherapy Complements Immune Checkpoint Blockade [PDF]

Cancer Cell, 2015
Adaptive immune resistance ablates effective anti-tumor immune responses. In a recent issue of Nature, Victor and colleagues describe that anti-PD-L1 combats adaptive immune resistance upon localized radiation plus anti-CTLA-4 therapy. The superior activity of radiation and dual immune checkpoint blockade is mediated by non-redundant immune mechanisms ...
Ngiow, Shin Foong, McArthur, Grant A., Smyth, Mark J.   +2 more
openaire   +4 more sources

Neutrophils in the era of immune checkpoint blockade [PDF]

Journal for ImmunoTherapy of Cancer, 2021
The immune checkpoint blockade-based immunotherapies are revolutionizing cancer management. Tumor-associated neutrophils (TANs) were recently highlighted to have a pivotal role in modulating the tumor microenvironment and the antitumor immune response.
Faget, Julien, Peters, Solange, Quantin, Xavier, Meylan, Etienne, Bonnefoy, Nathalie   +4 more
openaire   +5 more sources

Personalizing chronotherapy of immune checkpoint blockade. [PDF]

J Immunother Cancer
Emerging evidence highlights the critical role of time-of-day (ToD) in immunotherapy, with large-scale retrospective studies showing that administering immune checkpoint inhibitors (ICIs) earlier in the day is associated with significantly improved efficacy across all cancer types. This observation aligns with our growing understanding of the circadian
Ismail-Sutton S, Hughes B, Buchwald ZS, Wreglesworth NI, Dallmann R, Innominato PF.   +5 more
europepmc   +3 more sources

Immune checkpoint blockade in infectious diseases [PDF]

Nature Reviews Immunology, 2017
The upregulation of immune checkpoint molecules, such as programmed cell death protein 1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute infections, such as malaria, as well as during chronic persistent viral infections, including HIV and hepatitis B virus.
Wykes, MN, Lewin, SR
openaire   +3 more sources

Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity

Journal of Experimental & Clinical Cancer Research, 2021
Immune checkpoint inhibitors provide considerable therapeutic benefit in a range of solid cancers as well as in a subgroup of hematological malignancies.
Allan Relecom, Maysaloun Merhi, Varghese Inchakalody, Shahab Uddin, Darawan Rinchai, Davide Bedognetti, Said Dermime   +6 more
doaj   +1 more source

Immune-Checkpoint Blockade Therapy in Lymphoma [PDF]

International Journal of Molecular Sciences, 2020
Tumor cells use immune-checkpoint pathways to evade the host immune system and suppress immune cell function. These cells express programmed cell-death protein 1 ligand 1 (PD-L1)/PD-L2, which bind to the programmed cell-death protein 1 (PD-1) present on cytotoxic T cells, trigger inhibitory signaling, and reduce cytotoxicity and T-cell exhaustion ...
Ayumi Kuzume, SungGi Chi, Nobuhiko Yamauchi, Yosuke Minami   +3 more
openaire   +2 more sources

Programmed Cell Death Protein 1 Axis Inhibition in Viral Infections: Clinical Data and Therapeutic Opportunities

Vaccines, 2022
A vital function of the immune system is the modulation of an evolving immune response. It is responsible for guarding against a wide variety of pathogens as well as the establishment of memory responses to some future hostile encounters. Simultaneously,
Konstantinos Tsiakos, Niki Gavrielatou, Ioannis A. Vathiotis, Loukas Chatzis, Stamatios Chatzis, Garyfallia Poulakou, Elias Kotteas, Nikolaos K. Syrigos   +7 more
doaj   +1 more source