Results 61 to 70 of about 161,983 (298)
A review of immune checkpoint blockade in breast cancer.
Seminars in Oncology, 2021 In the recent years characterized by the cancer immunotherapy revolution, attention has turned to how to potentially boost and/or generate an efficient anti-tumor immune response in breast cancer (BC). Clinical activity of immune checkpoint blockade (ICB)
B. Pellegrino +11 more
semanticscholar +1 more source
Molecular Interactions of Antibody Drugs Targeting PD-1, PD-L1, and CTLA-4 in Immuno-Oncology
Molecules, 2019 Cancer cells can evade immune surveillance through the molecular interactions of immune checkpoint proteins, including programmed death 1 (PD-1), PD-L1, and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Since 2011, the FDA-approved antibody drugs
Hyun Tae Lee +2 more
doaj +1 more source
Acta oncologica, 2019 The pioneers who discovered the mechanisms for activation of cytotoxic T-cells and developed antibodies which inactivate the T-cell brakes, professor James P Allison, USA, and professor Tasuku Honjo, Japan, have recently been awarded the Nobel Prize in ...
O. Dahl, M. Brydøy
semanticscholar +1 more source
Cancer Medicine, 2023 Background Certain angiotensin receptor blockers (ARBs) have peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) activation property, which has been associated with improved programmed cell death ligand 1 blockade and cytotoxic T lymphocyte‐mediated ...
Cho‐Han Chiang +9 more
doaj +1 more source
Cell Communication and Signaling, 2022 Innate and adaptive immune cells patrol and survey throughout the human body and sometimes reside in the tumor microenvironment (TME) with a variety of cell types and nutrients that may differ from those in which they developed.
Hamidreza Zalpoor +7 more
doaj +1 more source
European Journal of Cancer, 2023 For patients with advanced thymic epithelial tumours (TET), there is no standard second-line treatment after platinum-based chemotherapy. Although immune checkpoint blockers (ICB) are a potential treatment strategy, their efficacy seems limited with an increased risk of immune-related adverse events (ir-AEs), thus hampering their application in daily ...
Jordi Remon +8 more
openaire +4 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Brain Sciences, 2022 Low-grade glioma (LGG) is a highly aggressive disease in the skull. On the other hand, anoikis, a specific form of cell death induced by the loss of cell contact with the extracellular matrix, plays a key role in cancer metastasis. In this study, anoikis-
Songyun Zhao +7 more
doaj +1 more source
The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma: A Review.
JAMA Oncology, 2020 Importance For more than a decade, sorafenib has been the only systemic treatment option for patients with advanced hepatocellular carcinoma (HCC). However, rapid progress over the past few years led to approval of other angiogenesis inhibitors and ...
M. Pinter, R. Jain, D. Duda
semanticscholar +1 more source
Novel immune checkpoint blocker approved for the treatment of advanced melanoma
OncoImmunology, 2014 A few days ago, on September 4th, 2014, the US Food and Drug Administration (FDA) granted accelerated approval to pembrolizumab, a monoclonal antibody formerly known as lambrolizumab that specifica...
Lorenzo Galluzzi +2 more
openaire +2 more sources