Results 121 to 130 of about 3,908,577 (301)

Population-level toggling of T cell immune escape at human leukocyte antigen anchor residues in SARS-CoV-2 Spike proteins, in an ethnically diverse population region.

PLoS Computational Biology
There is currently limited understanding of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) adaptation to the human leukocyte antigen (HLA) proteins which mediate CD8 (HLA-I) and CD4 (HLA-II) T cell immune responses.
Nobubelo K Ngandu, Burtram C Fielding, Peter van Heusden, Kuhle Mcinga, Kriheska Francis, Gordon Harkins   +5 more
doaj   +1 more source

Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development

Advances in Virology, 2012
The HIV-1 genome is malleable and a difficult target tot vaccinate against. It has long been recognised that cytotoxic T lymphocytes and neutralising antibodies readily select for immune escape HIV variants.
Gamze Isitman, Ivan Stratov, Stephen J. Kent   +2 more
doaj   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Tumor-immune metaphenotypes orchestrate an evolutionary bottleneck that promotes metabolic transformation

Frontiers in Immunology
IntroductionMetabolism plays a complex role in the evolution of cancerous tumors, including inducing a multifaceted effect on the immune system to aid immune escape.
Jeffrey West, Frederika Rentzeperis, Casey Adam, Rafael Bravo, Kimberly A. Luddy, Mark Robertson-Tessi, Alexander R. A. Anderson   +6 more
doaj   +1 more source

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg   +2 more
wiley   +1 more source

No Escape

, 2022
“I was once a child with a dream looking up to the stars. Now I’m an adult in a spaceship looking down to our beautiful Earth. To the next generation of dreamers: if we can do this, imagine what we can do.” – Richard Branson (2021) Tech billionaires ...
Craighead, A.
core   +3 more sources

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Comprehensive analysis of immune escape-related prognostic signature in high-grade glioma

Discover Oncology
Objective High-grade glioma (HGG) is one of the most lethal malignancies. Immune escape is considered to be a reason for the failure of immunotherapy for HGG patients, and there is currently no immune escape-related prognostic model for glioma. Therefore,
Chongkang Ren, Jinyi Cai, Yanhua Liu, Zeshang Guo, Xinyu Hong   +4 more
doaj   +1 more source

Bibliometric and visualized analysis of global distribution and research frontiers in tumor immune escape

Frontiers in Immunology
BackgroundTumor cells employ various mechanisms to evade detection and attack by the immune system, a phenomenon known as tumor immune escape, which represents a significant target for immunotherapy.
Chaihong Zhang, Lihong Chen
doaj   +1 more source