Results 51 to 60 of about 1,940,572 (373)

Evolution of enhanced innate immune evasion by SARS-CoV-2

Nature, 2021
The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance human-to-human transmission1,2. Although much effort has focused on the characterization of changes in the spike protein in variants of concern, mutations outside of ...
Lucy G. Thorne, Mehdi Bouhaddou, Ann-Kathrin Reuschl, L. Zuliani-Alvarez, Benjamin J. Polacco, A. Pelin, J. Batra, M. Whelan, M. Hosmillo, A. Fossati, Roberta Ragazzini, Irwin Jungreis, Manisha Ummadi, Ajda Rojc, Jane Turner, Marie L. Bischof, K. Obernier, Hannes Braberg, Margaret Soucheray, Alicia L. Richards, Kuei-Ho Chen, Bhavya Harjai, D. Memon, J. Hiatt, R. Rosales, B. McGovern, A. Jahun, Jacqueline M. Fabius, K. White, I. Goodfellow, Yasuyuki Takeuchi, P. Bonfanti, K. Shokat, N. Jura, K. Verba, M. Noursadeghi, P. Beltrão, Manolis Kellis, D. Swaney, A. García-Sastre, C. Jolly, G. Towers, N. Krogan   +42 more
semanticscholar   +1 more source

Immune evasion of the CD1d/NKT cell axis [PDF]

, 2018
Many reviews on the CD1d/NKT cell axis focus on the ability of CD1d-restricted NKT cells to serve as effector cells in a variety of disorders, be they infectious diseases, cancer or autoimmunity.
Brutkiewicz, Randy R., Liu, Jianyun, Yunes-Medina, Laura   +2 more
core   +1 more source

Filoviral Immune Evasion Mechanisms

Viruses, 2011
The Filoviridae family of viruses, which includes the genera Ebolavirus (EBOV) and Marburgvirus (MARV), causes severe and often times lethal hemorrhagic fever in humans. Filoviral infections are associated with ineffective innate antiviral responses as a
Christopher F. Basler, Gaya K. Amarasinghe, Craig S. Brown, Reed S. Shabman, Parameshwaran Ramanan, Daisy W. Leung   +5 more
doaj   +1 more source

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

Signal Transduction and Targeted Therapy, 2022
The persistent COVID-19 pandemic since 2020 has brought an enormous public health burden to the global society and is accompanied by various evolution of the virus genome.
Cong Sun, Chuanqi Xie, Guojun Bu, L. Zhong, M. Zeng   +4 more
semanticscholar   +1 more source

Immune evasion in cancer: mechanistic basis and therapeutic strategies [PDF]

, 2015
Cancer immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Although considerable progress has been made in understanding how cancers evade destructive immunity, measures to counteract tumor escape have not ...
Amin, Amr, Aquilano, Katia, Ashraf, S. Salman, Azmi, Asfar S., Bhakta, Dipita, Bilsland, Alan, Boosani, Chandra S., Chen, Sophie, Choi, Beom K., Ciriolo, Maria Rosa, Decker, William K., Elkord, Eyad, Fujii, Hiromasa, Georgakilas, Alexandros G., Guha, Gunjan, Halicka, Dorota, Helferich, William G., Honoki, Kanya, Keith, W. Nicol, Kumara, H.M.C. Shantha, Kwona, Byoung S., Lichtor, Terry, Mohammed, Sulma I., Nowsheen, Somaira, Pawelec, Graham, Ryan, Elizabeth P., Signori, Emanuela, Stagg, John, Talib, Wamidh H., Vinay, Dass S., Whelan, Richard L., Yang, Xujuan   +31 more
core   +1 more source

Ovarian cancer mutational processes drive site-specific immune evasion

Nature, 2022
High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability 1 – 4 patterned by distinct mutational processes 5 , 6 , tumour heterogeneity 7 – 9 and intraperitoneal spread 7 , 8 , 10 .
I. Vázquez-García, F. Uhlitz, Nicholas Ceglia, J. Lim, Michelle Wu, N. Mohibullah, Juliana Niyazov, A. Ruiz, Kevin M. Boehm, V. Bojilova, Christopher J. Fong, Tyler Funnell, Diljot S. Grewal, Eliyahu Havasov, Samantha Leung, Arfath Pasha, Druv M. Patel, Maryam Pourmaleki, Nicole Rusk, Hongyu Shi, R. Vanguri, Marc J. Williams, Allen W. Zhang, V. Broach, D. Chi, A. Da Cruz Paula, G. Gardner, Sarah H. Kim, M. Lennon, K. L. Long Roche, Y. Sonoda, O. Zivanovic, Ritika Kundra, A. Viale, F. Derakhshan, Luke Geneslaw, Shirin Issa Bhaloo, A. Maroldi, Rahelly Nunez, F. Pareja, A. Stylianou, M. Vahdatinia, Y. Bykov, R. Grisham, Ying-lan Liu, Y. Lakhman, I. Nikolovski, D. Kelly, Jianjiong Gao, A. Schietinger, T. Hollmann, S. Bakhoum, R. Soslow, Lora H. Ellenson, N. Abu-Rustum, C. Aghajanian, C. Friedman, A. McPherson, B. Weigelt, D. Zamarin, Sohrab P. Shah   +60 more
semanticscholar   +1 more source

Extracellular vesicles in ovarian cancer chemoresistance, metastasis, and immune evasion

Cell Death and Disease, 2022
Chemoresistance and metastasis are the major challenges for the current ovarian cancer treatment. Understanding the mechanisms of ovarian cancer progression and metastasis is critically important for developing novel therapies.
W. Tian, Ningjing Lei, Junying Zhou, Mengyu Chen, R. Guo, B. Qin, Yong Li, Lei Chang   +7 more
semanticscholar   +1 more source

Physical Model of the Immune Response of Bacteria Against Bacteriophage Through the Adaptive CRISPR-Cas Immune System [PDF]

Phys. Biol. 10 (2013) 025004, 2014
Bacteria and archaea have evolved an adaptive, heritable immune system that recognizes and protects against viruses or plasmids. This system, known as the CRISPR-Cas system, allows the host to recognize and incorporate short foreign DNA or RNA sequences, called `spacers' into its CRISPR system.
arxiv   +1 more source

The essential role of mitochondrial dynamics in antiviral immunity. [PDF]

, 2018
Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation.
Ahn, Dae-Gyun, Kim, Seong-Jun, Siddiqui, Aleem, Syed, Gulam H   +3 more
core   +2 more sources

Neuroimmune Evasion of Zika Virus to Facilitate Viral Pathogenesis

Frontiers in Cellular and Infection Microbiology, 2021
Zika virus (ZIKV), which preferentially targets neural stem and progenitor cells (NSCs) especially in developing brain, is causally associated with fetal microcephaly, intrauterine retardation, and other congenital malformations in humans. However, there
Xiaochun Xie, Jianxiong Zeng, Jianxiong Zeng, Jianxiong Zeng   +3 more
doaj   +1 more source