Results 61 to 70 of about 121,779 (302)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Tumor Immune Evasion [PDF]

Science, 2010
Malignant cells can induce the formation of lymphoid tissue–like structures that help the tumor evade host immunity.
David D. Chaplin, Carlene L. Zindl
openaire   +2 more sources

Immune subtypes and neoantigen-related immune evasion in advanced colorectal cancer

iScience, 2022
Summary: Elimination of cancerous cells by the immune system is an important mechanism of protection from cancer, however, its effectiveness can be reduced owing to development of resistance and evasion.
Toshitaka Sugawara, Fuyuki Miya, Toshiaki Ishikawa, Artem Lysenko, Jo Nishino, Takashi Kamatani, Akira Takemoto, Keith A. Boroevich, Kazuhiro Kakimi, Yusuke Kinugasa, Minoru Tanabe, Tatsuhiko Tsunoda   +11 more
doaj  

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Immune evasion strategies of the herpesviruses

Chemistry & Biology, 1996
All viruses can deal with the immune response to some extent, and herpesviruses are exceptionally sophisticated in this ability. Recent work has uncovered some of the mechanisms by which herpesviruses subvert the antigen-presentation systems of their host cells.
openaire   +3 more sources

Extracellular vesicle‐packaged lncRNA from cancer‐associated fibroblasts promotes immune evasion by downregulating HLA‐A in pancreatic cancer

Journal of Extracellular Vesicles
Pancreatic ductal adenocarcinoma (PDAC) is characterised by immune evasion that contribute to poor prognosis. Cancer‐associated fibroblasts (CAFs) play a pivotal role in orchestrating the PDAC tumour microenvironment.
Hanming Yao, Chengzhi Huang, Jinmao Zou, Weiling Liang, Yue Zhao, Kege Yang, Ziyi Zhong, Shurui Zhou, Jiajia Li, Yaqing Li, Lishu Xu, Kaihong Huang, Guoda Lian   +12 more
doaj   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Immune evasion mechanisms of arenaviruses

Oncotarget, 2015
Arenaviruses, such as Lassa virus (LASV), can cause fatal human hemorrhagic fever (HF) diseases for which licensed vaccines and effective therapies are currently unavailable [1]. These viruses have been shown to initiate the infection by targeting the antigen presenting cells (APCs), such as dendritic (DC) and macrophage (MP) cells [1].
Yuying Liang, Hinh Ly
openaire   +3 more sources