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Nutraceuticals in Immune Function [PDF]

Molecules, 2021
Nutraceutical, a term derived from ‘nutrition’ and ‘pharmaceutical’, refers to any product isolated from herbs, nutrients, specific diets, processed foods, and beverages used not only for nutritional but also for medicinal purposes [...]
Soo-Liang Ooi, Sok-Cheon Pak
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Nitric Oxide and Electrophilic Cyclopentenone Prostaglandins in Redox signaling, Regulation of Cytoskeleton Dynamics and Intercellular Communication

Frontiers in Cell and Developmental Biology, 2021
Nitric oxide (NO) and electrophilic cyclopentenone prostaglandins (CyPG) are local mediators that modulate cellular response to oxidative stress in different pathophysiological processes. In particular, there is increasing evidence about their functional
Ángel Bago, Miguel A. Íñiguez, Miguel A. Íñiguez, Juan M. Serrador   +3 more
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Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution

Frontiers in Immunology, 2022
Notch signaling is crucial for fate specification and maturation of thymus-seeding progenitors along the T-cell lineage. Recent studies have extended the role of Notch signaling to thymic epithelial cells (TECs), showing that Notch regulates TEC ...
María Jesús García-León, Marta Mosquera, Carmela Cela, Juan Alcain, Saulius Zuklys, Georg Holländer, Georg Holländer, María L. Toribio   +7 more
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Characterization of Three Somatic Mutations in the 3′UTR of RRAS2 and Their Inverse Correlation with Lymphocytosis in Chronic Lymphocytic Leukemia

Cells, 2023
Chronic lymphocytic leukemia (CLL) is a hematologic malignancy characterized by progressive accumulation of a rare population of CD5+ B-lymphocytes in peripheral blood, bone marrow, and lymphoid tissues.
Marta Lacuna, Alejandro M. Hortal, Claudia Cifuentes, Tania Gonzalo, Miguel Alcoceba, Miguel Bastos, Xosé R. Bustelo, Marcos González, Balbino Alarcón   +8 more
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Diet and Immune Function [PDF]

Nutrients, 2019
A well-functioning immune system is critical for survival. The immune system must be constantly alert, monitoring for signs of invasion or danger. Cells of the immune system must be able to distinguish self from non-self and furthermore discriminate between non-self molecules which are harmful (e.g., those from pathogens) and innocuous non-self ...
Childs, Caroline, Calder, Philip, Miles, Elizabeth   +2 more
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Research progress of functional motifs based on growth factors in cartilage tissue engineering: A review

Frontiers in Bioengineering and Biotechnology, 2023
Osteoarthritis is a chronic degenerative joint disease that exerts significant impacts on personal life quality, and cartilage tissue engineering is a practical treatment in clinical. Various growth factors are involved in cartilage regeneration and play
Shengao Qin, Shengao Qin, Jiaman Zhu, Jiaman Zhu, Guangyong Zhang, Guangyong Zhang, Qijia Sui, Qijia Sui, Yimeng Niu, Yimeng Niu, Weilong Ye, Weilong Ye, Guowu Ma, Guowu Ma, Huiying Liu, Huiying Liu   +15 more
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Comparing Traditional and Toxin-Oriented Approaches towards Antivenom Production against Bitis arietans Snake Venom

Toxins, 2023
Accidents with snakes are responsible for about 32,000 deaths annually in sub-Saharan Africa, caused mostly by snakes from the genus Bitis, in particular Bitis arietans. B.
Felipe Raimondi Guidolin, Kemily Stephanie de Godoi, Angela Alice Amadeu Megale, Cristiane Castilho Fernandes da Silva, Roberto Tadashi Kodama, Daniela Cajado-Carvalho, Leo Kei Iwai, Patrick Jack Spencer, Fernanda Calheta Vieira Portaro, Wilmar Dias da Silva   +9 more
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CXCL12-stimulated lymphocytes produce secondary stimulants that affect the surrounding cell chemotaxis

Biochemistry and Biophysics Reports, 2021
Chemotactic factors locally secreted from tissues regulate leukocyte migration via cell membrane receptors that induce intracellular signals. It has been suggested that neutrophils stimulated by bacterial peptides secrete a secondary stimulant that ...
Kaoru Kurowarabe, Masataka Endo, Daichi Kobayashi, Haruko Hayasaka   +3 more
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Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

eLife, 2022
Medullary thymic epithelial cells (mTECs) are critical for self-tolerance induction in T cells via promiscuous expression of tissue-specific antigens (TSAs), which are controlled by the transcriptional regulator, AIRE.
Takahisa Miyao, Maki Miyauchi, S Thomas Kelly, Tommy W Terooatea, Tatsuya Ishikawa, Eugene Oh, Sotaro Hirai, Kenta Horie, Yuki Takakura, Houko Ohki, Mio Hayama, Yuya Maruyama, Takao Seki, Hiroto Ishii, Haruka Yabukami, Masaki Yoshida, Azusa Inoue, Asako Sakaue-Sawano, Atsushi Miyawaki, Masafumi Muratani, Aki Minoda, Nobuko Akiyama, Taishin Akiyama   +22 more
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Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia

Molecular Cancer, 2022
Background Chronic lymphocytic leukemia (CLL) is the most frequent, and still incurable, form of leukemia in the Western World. It is widely accepted that cancer results from an evolutionary process shaped by the acquisition of driver mutations which ...
Alejandro M. Hortal, Clara L. Oeste, Claudia Cifuentes, Miguel Alcoceba, Isabel Fernández-Pisonero, Laura Clavaín, Rut Tercero, Pilar Mendoza, Verónica Domínguez, Marta García-Flores, Belén Pintado, David Abia, Carmen García-Macías, Almudena Navarro-Bailón, Xosé R. Bustelo, Marcos González, Balbino Alarcón   +16 more
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