Results 101 to 110 of about 443 (202)

Immune Imprinting Identified in Phage-Display Antibody Libraries Derived from Early Wild-Type and Late Omicron COVID-19 Convalescents

Viruses
The rapid evolution of SARS-CoV-2, particularly the emergence of Omicron subvariants, has significantly reduced the efficacy of existing vaccines and monoclonal antibodies.
Boyang Li, Mengxuan Wang, Fang Huang, Wei Wu, Jiaxin Fan, Lu Yang, Yongbing Pan, Mifang Liang, Kai Duan   +8 more
doaj   +1 more source

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

International Journal of Cancer, EarlyView.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat, Francesco Cecere, Federica Rossetti, Laura Pignata, Emilia D'Angelo, Carlo Giaccari, Gaetano Verde, Paola Quarello, Franca Fagioli, Josep Roma, Manel Esteller, Enrique de Álava, Flavia Cerrato, Andrea Riccio, Angela Sparago   +14 more
wiley   +1 more source

Linking S. aureus Immune Evasion Mechanisms to Staphylococcal Vaccine Failures

Antibiotics
Vaccination arguably remains the only long-term strategy to limit the spread of S. aureus infections and its related antibiotic resistance. To date, however, all staphylococcal vaccines tested in clinical trials have failed.
Irshad Ahmed Hajam, George Y. Liu
doaj   +1 more source

Exposure–Recovery Approach for Hepatic Toxicity Analysis of Pyrethroid Lambda‐Cyhalothrin: Histopathological, Histochemical, and Biochemical Responses in Oreochromis niloticus

Journal of Applied Toxicology, EarlyView.
ABSTRACT Lambda‐cyhalothrin is a synthetic pyrethroid insecticide widely used in agriculture, but its potential to contaminate aquatic ecosystems and exert high toxicity on fish at low concentrations raises ecotoxicological concerns. While standard histopathological and biochemical assessments are common, the novel integration of pigment‐based ...
Carlos Eurico Fernandes, André Luiz do Nascimento Silva, Tiago Venancio da Silva, Karine Nathiele Nogueira Farias, Sabrina Fuzer Gonçalves, Brenda de Oliveira Martins, Maria Eduarda Corona Garcia, Lilian Franco‐Belussi   +7 more
wiley   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Proteomic signals are not equal clinical phenotypes: redefining evidence standards in arbovirus–SARS-CoV-2 cross-reactivity

Frontiers in Immunology
The interaction between SARS-CoV-2 and dengue virus represents a biologically plausible yet clinically unresolved challenge in regions where both pathogens co-circulate.
Ibzan Jahzeel Salvador Ibarra, Zoila Mora Guzmán, Zoila Mora Guzmán, Anahí Jobeth Borrás Enríquez, Juan Alpuche, Gilberto Castañeda-Hernández, Eduardo Pérez-Campos, María Teresa Hernández-Huerta, María Teresa Hernández-Huerta, Hector Alejandro Cabrera-Fuentes, Hector Alejandro Cabrera-Fuentes, Hector Alejandro Cabrera-Fuentes, Hector Alejandro Cabrera-Fuentes   +12 more
doaj   +1 more source

Exclusive enteral nutrition containing transforming growth factor‐β improves intestinal barrier function in a colitis mouse model

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Exclusive enteral nutrition (EEN) is the first‐line treatment for pediatric Crohn's disease, but its mechanisms of action remain poorly understood. Our aim was to identify the mechanisms that could explain the anti‐inflammatory effects of EEN, studying the nutritional composition and transforming growth factor‐β (TGF‐β) effects, in ...
Kawthar Boumessid, Vickie Lacroix, Ekaterina Ovtchinnikova, Sophie Thenet, Marie Carriere, Frédérick Barreau, Emmanuel Mas   +6 more
wiley   +1 more source

Bivalent mRNA booster encoding virus-like particles elicits potent polyclass receptor-binding domain antibodies in pre-vaccinated mice

eLife
mRNA vaccines emerged as a leading vaccine technology during the COVID-19 pandemic. However, their sustained protective efficacies were limited by relatively short-lived antibody responses and the emergence of SARS-CoV-2 variants, necessitating frequent ...
Chengcheng Fan, Alexander A Cohen, Kim-Marie A Dam, Annie V Rorick, Ange-Célia I Priso Fils, Zhi Yang, Priyanthi NP Gnanapragasam, Luisa N Segovia, Kathryn E Huey-Tubman, Woohyun J Moon, Paulo JC Lin, Pamela J Bjorkman, Magnus AG Hoffmann   +12 more
doaj   +1 more source

Early‐life adverse events and risk of inflammatory bowel disease: A Scandinavian birth cohort study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives The experience of childhood stressful or adverse life events is believed to imprint on immunological pathways and, therefore, might have lasting effects on inflammatory bowel disease (IBD) development. This study aimed to examine the association between experiences of early‐life adverse events and later IBD risk. Methods We followed
Ida Sigvardsson, Ketil Størdal, Henrik Imberg, Elisabeth Fernell, Christopher Gillberg, Johnny Ludvigsson, Karl Mårild   +6 more
wiley   +1 more source

Assessing evidence of immune imprinting in serological patterns of influenza immune response

The subtype of the first influenza infection shapes infection risk, illness and mortality associated with subsequent infection subtypes, as well as vaccine efficacy. This phenomenon, termed ‘immune imprinting’, may result from immune recognition rooted in structural similarity of the hemagglutinin protein within subtypes of influenza viruses.
Bernardo García-Carreras, Bingyi Yang, James A. Hay, C. Jessica E. Metcalf, Matt D. T. Hitchings, Claire P. Smith, Siyu Chen, Jonathan M. Read, Huachen Zhu, Chaoqiang Jiang, Kin On Kwok, Steven Riley, Sarah Cobey, Justin Lessler, Derek A. T. Cummings   +14 more
openaire   +1 more source