Results 81 to 90 of about 443 (202)

Persistent Interleukin‐18 Fuels Expansion of CD38+HLA‐DR+CD8+ T Cells in Still Disease and Macrophage Activation Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani, Remco G. A. Erkens, Alejandra Bodelón, Tim R. Mocking, Marein T. M. Putmans, Freya M. C. H. Huijsmans, Lyanne J. P. M. Sijbers, Aafke M. De Ligt, Maurice J. H. Van Haaren, Rianne C. Scholman, Noël M. M. Dautzenberg, Joyce I. Meesters‐Ensing, Martina Rossano, Laura Porretti, Stefan Nierkens, Francesca S. Minoia, Sebastiaan J. Vastert, Jorg van Loosdregt   +17 more
wiley   +1 more source

Profiling serum immunodominance following SARS-CoV-2 primary and breakthrough infection reveals distinct variant-specific epitope usage and immune imprinting.

PLoS Pathogens
Over the course of the COVID-19 pandemic, variants have emerged with increased mutations and immune evasive capabilities. This has led to breakthrough infections (BTI) in vaccinated individuals, with a large proportion of the neutralizing antibody ...
Jeffrey Seow, George C E Jefferson, Michael D Keegan, Yeuk Yau, Luke B Snell, Katie J Doores   +5 more
doaj   +1 more source

Historical H1N1 Influenza Virus Imprinting Increases Vaccine Protection by Influencing the Activity and Sustained Production of Antibodies Elicited at Vaccination in Ferrets

Vaccines, 2019
Influenza virus imprinting is now understood to significantly influence the immune responses and clinical outcome of influenza virus infections that occur later in life.
Magen E. Francis, Mara McNeil, Nicholas J. Dawe, Mary K. Foley, Morgan L. King, Ted M. Ross, Alyson A. Kelvin   +6 more
doaj   +1 more source

Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy

BMEMat, EarlyView.
This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang, Jiawei Cui, Jin Wang, Manfred F. Maitz, Rifang Luo, Yunbing Wang   +5 more
wiley   +1 more source

Birth imprinting effects on the antibody responses of H7N9 patients from 2013-2018 in China

Communications Medicine
Background There is an urgent need to understand the immune correlates of protection against avian influenza viruses (AIV), where pre-existing immunity may be limited.
Xia Lin, Wenda Guan, Liping Chen, Yin Su, Zaolan Liang, Cheng Xiao, Yaqin Bai, Hui Lei, Fangmei Lin, Zhenting Huang, Isaac Cheuk Long Chow, Bingyi Yang, Tim K. Tsang, Yunceng Weng, Nisha Bhandari, Raghavan Varadarajan, Malik Peiris, Benjamin Cowling, Tang Li, Maureen McGargill, Paul G. Thomas, Nanshan Zhong, Richard Webby, Zifeng Yang, Mark Zanin, Sook-San Wong   +25 more
doaj   +1 more source

Risk assessment of 2024 cattle H5N1 using age-stratified serosurveillance data

Emerging Microbes and Infections
The highly pathogenic avian influenza virus A(H5N1) clade 2.3.4.4b has caused a human outbreak in North America since March 2024. Here, we conducted a serosurveillance study to determine the risk of A(H5N1) clade 2.3.4.4b (2024 cattle H5N1) to general ...
Lin-Lei Chen, Xiaojuan Zhang, Kang Zhang, Brian Pui-Chun Chan, Jacqueline Kwan Yuk Yuen, Kwok-Yung Yuen, Pui Wang, Yuhe R. Yang, Honglin Chen, Kelvin Kai-Wang To   +9 more
doaj   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Characterizing immune activation in HIV-exposed but uninfected infants in the first year of life

Frontiers in Immunology
IntroductionHIV-exposed uninfected (HEU) infants experience multiple health complications compared to HIV-unexposed (HUU) infants, including immune dysregulation in the first year of life.
Isabelle Roseto, Lori Silveira, Kaili Curtis, Jennifer Canniff, Adriana Weinberg, Adriana Weinberg, Christiana Smith   +6 more
doaj   +1 more source

Intestinal Epithelial Memory: From Inflammatory Imprinting to Metabolite‐Shaped Immune Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Intestinal epithelial cells are rapidly renewing barrier cells that maintain compartmentalization between the luminal environment and the mucosal immune system through epithelial transport, antimicrobial defense, secretory programs, and cytokine‐mediated communication.
Wenjing Yang, Tianming Yu, Yingzi Cong
wiley   +1 more source

Differential antigenic imprinting effects between influenza H1N1 hemagglutinin and neuraminidase in a mouse model

Journal of Virology
Understanding how immune history influences influenza immunity is essential for developing effective vaccines and therapeutic strategies. This study examines the antigenic imprinting of influenza hemagglutinin (HA) and neuraminidase (NA) using a mouse ...
Huibin Lv, Qi Wen Teo, Chang-Chun D. Lee, Weiwen Liang, Danbi Choi, Kevin J. Mao, Madison R. Ardagh, Akshita B. Gopal, Arjun Mehta, Matt Szlembarski, Roberto Bruzzone, Ian A. Wilson, Nicholas C. Wu, Chris K. P. Mok   +13 more
doaj   +1 more source