Results 141 to 150 of about 1,838,932 (310)

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Integrated analysis of scRNA-seq and bulk RNA-seq reveals that GPRC5A is an important prognostic gene in pancreatic cancer and is associated with B-cell Infiltration in pancreatic cancer

Frontiers in Oncology
IntroductionPancreatic cancer (PC) is a malignancy with poor prognosis. This investigation aimed to determine the relevant genes that affect the prognosis of PC and investigate their relationship with immune infiltration.Methods: First, we acquired PC ...
Chunlu Dong, Chunlu Dong, Haidong Ma, Ningning Mi, Wenkang Fu, Jianfeng Yi, Jianfeng Yi, Long Gao, Haiping Wang, Haiping Wang, Yanxian Ren, Yanxian Ren, Yanyan Lin, Yanyan Lin, Fangfang Han, Fangfang Han, Zhou Chen, Zhou Chen, Wence Zhou, Wence Zhou   +19 more
doaj   +1 more source

Prognostic and immune infiltration implications of SIGLEC9 in SKCM

Diagnostic Pathology
The occurrence and progression of skin cutaneous melanoma (SKCM) is strongly associated with immune cells infiltrating the tumor microenvironment (TME). This study examined the expression, prognosis, and immune relevance of SIGLEC9 in SKCM using multiple online databases.
Peipei Yang, Yunhui Jiang, Rong Chen, Junhan Yang, Mengting Liu, Xieping Huang, Ganglin Xu, Rui Hao   +7 more
openaire   +3 more sources

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively.
Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L. S. Benzinger, Qing Wang, Matthew R. Brier   +10 more
wiley   +1 more source

Screening of Diagnostic Biomarkers and Immune Infiltration Characteristics Linking Rheumatoid Arthritis and Rosacea Based on Bioinformatics Analysis [PDF]

Yun Wang,1 Jun Chen,1 Zheng-Yu Shen,1 Jie Zhang,2 Yu-Jie Zhu,1 Xu-Qiong Xia1 1Department of Dermatology, Shanghai Ninth People’s Hospital Affiliated Shanghai JiaoTong University School of Medicine, Shanghai, 200080, People’s Republic of China; 2The ...
Chen J, Zhang J, Xia XQ, Zhu YJ, Wang Y, Shen ZY   +5 more
core  

Circulating IL6 is involved in the infiltration of M2 macrophages and CD8+ T cells

Scientific Reports
To elucidate the relationship between circulating cytokines and the prognosis of microsatellite-stable(MSS) colorectal cancer (CRC) patients, we examined the correlation between circulating cytokine levels and tumor immune infiltration microenvironment ...
Jing Huang, Rui Xiao, Suyujie Shi, Qingshu Li, Ming Li, Ming Xiao, Yalan Wang, Yaying Yang, Wenwen Li, Yi Tang   +9 more
doaj   +1 more source

New Insights Into the Correlation Between Necroptotic Activation and Neutrophil Infiltration in Pulpitis

International Dental Journal
Background: Pulpitis is a significant dental concern characterized by inflammation of the dental pulp, often causing severe pain and potential tooth loss.
Xiaolan Guo, Xinyan Ma, Peng Liu, Xiaoxin Chen, Sitong Liu, Longrui Dang, Buling Wu, Zhao Chen   +7 more
doaj   +1 more source

The immune cells infiltration after ESC-CEC and LSC transplantation.

, 2016
Representative immunofluorescence pictures of macrophages and NK cells infiltration 3 days after transplantation, CD4+ and CD8+ T cells infiltration 7 days after transplantation (green A). All immune cells were fewer in the ESC-CEC transplantation group (
Muchen Dong (3179073), Yao Wang (102387), Weiyun Shi (402729), Qingjun Zhou (178655), Haoyun Duan (402728), Zhenyu Wang (580934)   +5 more
core   +1 more source

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)

Arthritis Care &Research, EarlyView.
Objective Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome (VEXAS) syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures.
Kevin Byram, Heřman Mann, Danielle Hammond, Onima Chowdhury, Sinisa Savic, Yohei Kirino, Carmelo Gurnari, Maël Heiblig, Thibault Comont, Arsène Mekinian, Mrinal M. Patnaik, Lachelle D. Weeks, Gary Ho, Adam Al‐Hakim, Scott Goldberg, Marcela A. Ferrada, Sophie Georgin‐Lavialle, Peter C. Grayson, Emma M. Groarke, Bhavisha Patel, Megan Sullivan, Sarah A. Buckley, Bryan G. Harder, Raman Garcha, David B. Beck, Matthew J. Koster   +25 more
wiley   +1 more source