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Immune infiltrates and cytokines in gliomas
Acta Neurochirurgica, 1996Frozen sections of 21 gliomas were analysed to characterize inflammatory infiltrating cells, HLA-DR antigen expression and cytokine secretion. Mononuclear cells infiltrating the tumours were mostly macrophages, which were detected in 100% of cases, and expressed HLA-DR antigens.
Giometto B +5 more
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Heavy Metal to Rock the Immune Infiltrate
Trends in Immunology, 2017Two resource articles recently published in Cell demonstrate that the elevated phenotypic complexity of the immune infiltrate in human lung adenocarcinomas and renal cell carcinomas can be reliably dissected with mass cytometry. These findings may pave the way to a new era of precision cancer immunotherapy.
Lorenzo, Galluzzi +2 more
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Placenta immune infiltrates and perinatal outcomes
American Journal of Reproductive Immunology, 2018Pregnancy is a state of immunotolerance and loss of this immunotolerance may lead to fetal rejection, pregnancy complications, and neonatal complications. Immunobiology of pregnancy is complex and involves unique immune cell populations specific to pregnancy, changes in mucosal immune cells and peripheral immune system, and reciprocal adaptations ...
Maide Ozen +2 more
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Immune Cell Infiltration in Feline Meningioma
Journal of Comparative Pathology, 2017Meningioma is the most common primary brain tumour in the cat. Although most of these tumours are considered to be benign based on histological characteristics, little is known regarding microenvironmental changes associated with the tumour. The characterization of the immune-cell infiltrate in human and canine meningiomas has been described; however ...
R, McBride +3 more
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CCL21-induced immune cell infiltration
International Immunopharmacology, 2007Cellular immune responses can be initiated via peptide presentation by specialized antigen presenting cells, dendritic cells (DCs), which stimulate naïve T cells. The trafficking of DCs and T cells is regulated by chemokines such as CCL21. CCL21 is normally expressed in the lymphoid organs and coordinates the interactions between DCs and T cells ...
Abdelkader E, Ashour +4 more
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A multiplexed view of immune infiltration
Nature Reviews Cancer, 2018Keren et al. have used multiplexed imaging in intact samples from breast cancer patients to gain insights into the architecture of the tumour immune microenvironment.
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Decidual Immune Cell Infiltrate in Hydatidiform Mole
Cancer Investigation, 2009Hydatidiform mole is a gestational trophoblastic disease characterized by proliferation of the pregnancy-associated trophoblastic tissue. Complete hydatidiform mole is an entirely paternally derived lesion, and therefore, represents complete intrauterine allografts that can induce an altered maternal immune response Hypothesis: Here, we hypothesize ...
Mahmoud R, Hussein +3 more
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Variability in immune infiltrates and HLA expression in cholangiocarcinoma.
Journal of Clinical Oncology, 2014230 Background: Cholangiocarcinoma continues to have a dismal prognosis. The lack of effective therapy prompted us to determine whether patients develop an immune response against their own tumors. The aim of this study is to evaluate the CD8 infiltrate and expression of HLA class I antigen processing machinery (APM) components in cholangiocarcinoma.
Sabbatino, Francesco +11 more
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Tumor infiltrating immune cells in gliomas and meningiomas
Brain, Behavior, and Immunity, 2016Tumor-infiltrating immune cells are part of a complex microenvironment that promotes and/or regulates tumor development and growth. Depending on the type of cells and their functional interactions, immune cells may play a key role in suppressing the tumor or in providing support for tumor growth, with relevant effects on patient behavior.
Domingues, Patrícia +11 more
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