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Stem Cell Transplantation As A Dynamical System: Are Clinical Outcomes Deterministic? [PDF]

Frontiers in Immunology (2014). 5:613, 2014
Outcomes in stem cell transplantation (SCT) are modeled using probability theory. However the clinical course following SCT appears to demonstrate many characteristics of dynamical systems, especially when outcomes are considered in the context of immune reconstitution.
Buck, Gregory A, Chung, Harold, Clark, William, Jameson-Lee, Max, Kobulnicky, Jared D, Koparde, Vishal, Manjili, Masoud H, McCarty, John, Meier, Jeremy, Neale, Michael C, Roberts, Catherine H, Sabo, Roy T, Salman, Salman, Scalora, Allison, Serrano, Myrna, Sheth, Nihar, Toor, Amir A   +16 more
arxiv   +5 more sources

Fish Collagen Peptides Protect against Cisplatin-Induced Cytotoxicity and Oxidative Injury by Inhibiting MAPK Signaling Pathways in Mouse Thymic Epithelial Cells

Marine Drugs, 2022
Thymic epithelial cells (TECs) account for the most abundant and dominant stromal component of the thymus, where T cells mature. Oxidative- or cytotoxic-stress associated injury in TECs, a significant and common problem in many clinical settings, may ...
Won Hoon Song, Hye-Yoon Kim, Ye Seon Lim, Seon Yeong Hwang, Changyong Lee, Do Young Lee, Yuseok Moon, Yong Jung Song, Sik Yoon   +8 more
doaj   +1 more source

Recent advances in poor HIV immune reconstitution: what will the future look like?

Frontiers in Microbiology, 2023
Combination antiretroviral therapy has demonstrated proved effectiveness in suppressing viral replication and significantly recovering CD4+ T cell count in HIV type-1 (HIV-1)-infected patients, contributing to a dramatic reduction in AIDS morbidity and ...
Wenyuan Zhang, Lianguo Ruan
doaj   +1 more source

Fish Collagen Peptides Enhance Thymopoietic Gene Expression, Cell Proliferation, Thymocyte Adherence, and Cytoprotection in Thymic Epithelial Cells via Activation of the Nuclear Factor-κB Pathway, Leading to Thymus Regeneration after Cyclophosphamide-Induced Injury

Marine Drugs, 2023
Prolonged thymic involution results in decreased thymopoiesis and thymic output, leading to peripheral T-cell deficiency. Since the thymic-dependent pathway is the only means of generating fully mature T cells, the identification of strategies to enhance
Do Young Lee, Won Hoon Song, Ye Seon Lim, Changyong Lee, Lata Rajbongshi, Seon Yeong Hwang, Byoung Soo Kim, Dongjun Lee, Yong Jung Song, Hwi-Gon Kim, Sik Yoon   +10 more
doaj   +1 more source

Is immunological recovery clinically relevant at 100 days after allogeneic transplantation? [PDF]

The Korean Journal of Internal Medicine, 2020
Background/Aims Immune reconstitution following allogeneic hematopoietic stem cell transplantation (HSCT) is affected by multiple variables during the transplantation.
Jin Park, Sung Hee Lim, Se Hyung Kim, Jina Yun, Chan Kyu Kim, Sang Cheol Lee, Jong Ho Won, Dae Sik Hong, Seong Kyu Park   +8 more
doaj   +1 more source

Interaction of fibrinogen-magnetic nanoparticle bioconjugates with integrin reconstituted into artificial membranes [PDF]

Nanoscale, 2020, 12, 19918, 2020
Magnetic nanoparticles have a broad spectrum of biomedical applications including cell separation, diagnostics and therapy. One key issue is little explored: how do the engineered nanoparticles interact with blood components after injection? The formation of bioconjugates in the bloodstream and subsequent reactions are potentially toxic due to the ...
arxiv   +1 more source

Subdividing ART patients and analyzing the medical burden by modeling of CD4 cell count

Journal of Family Medicine and Primary Care, 2023
Objective: To subdivide the antiretroviral therapy (ART) human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) patients by modeling the CD4 cell count variable, with an aim to reduce the medical burden from lifelong ART. Materials
Li Min, Wang Qunwei
doaj   +1 more source

Comparison of immune reconstitution after allogeneic vs. autologous stem cell transplantation in 182 pediatric recipients

Pediatric Hematology Oncology Journal, 2017
Background: Hematopoietic stem cell transplantation (HSCT) is a life-saving procedure for children with a variety of malignant and non-malignant conditions. However, even if immune reconstitution after HSCT has been studied in extensively, until now data
V. Wiegering, M. Eyrich, B. Winkler, P.G. Schlegel   +3 more
doaj   +1 more source

Immune reconstitution after hematopoietic stem cell transplantation

Frontiers in Immunology, 2016
The reconstitution and the regaining of function of a healthy, transplanted immune system is of utmost importance for the recovery and long term survival of patients after HSCT.
Justyna Ogonek, Mateja Kralj Juric, Sakhila Ghimire, Pavankumar Varanasi, Ernst Holler, Hildegard Greinix, Eva Weissinger   +6 more
doaj   +1 more source

Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach [PDF]

, 2020
Haematopoiesis is the process of generation of blood cells. Lymphopoiesis generates lymphocytes, the cells in charge of the adaptive immune response. Disruptions of this process are associated with diseases like leukaemia, which is especially incident in children.
arxiv   +1 more source